[Hub]/) : Traits : Forced vital capacity (FVC) : ← →

chr12:30,084,002-31,526,510

Best TWAS P=1.18e-13 · Best GWAS P=4.88e-14 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	GTEx	Nerve Tibial	IPO8	0.21	0.16	lasso	6	0.15	1.3e-10	-7.4	-7.4	1.2e-13	1.00	0.02	0.98	TRUE
13	GTEx	Skin Sun Exposed Lower leg	IPO8	0.23	0.08	lasso	10	0.13	1.1e-10	-7.4	-7.2	5.8e-13	0.87	0.03	0.97	FALSE
11	GTEx	Lung	IPO8	0.07	0.06	lasso	5	0.07	7.5e-06	5.1	-7.1	1.1e-12	0.77	0.09	0.90	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	IPO8	0.22	0.14	lasso	4	0.14	2.5e-05	-7.5	-6.8	1.1e-11	0.88	0.03	0.97	FALSE
2	GTEx	Adipose Subcutaneous	IPO8	0.13	0.09	lasso	6	0.12	2.7e-10	5.1	-6.7	1.9e-11	0.79	0.29	0.71	FALSE
18	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IPO8	0.04	0.03	blup	58	0.03	9.7e-05	5.1	-6.4	1.9e-10	0.72	0.32	0.51	FALSE
17	The Cancer Genome Atlas	Lung Adenocarcinoma	IPO8	0.06	0.04	blup	58	0.04	1.5e-05	5.3	-6.3	3.3e-10	0.74	0.36	0.62	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	IPO8	0.05	0.03	lasso	3	0.03	1.3e-06	5.1	-5.9	4.6e-09	0.64	0.73	0.27	FALSE
4	GTEx	Artery Aorta	IPO8	0.17	0.06	enet	29	0.04	2.2e-03	-7.4	-5.8	5.1e-09	0.69	0.02	0.97	FALSE
9	GTEx	Esophagus Muscularis	IPO8	0.24	0.19	lasso	6	0.18	5.7e-11	5.4	-5.7	1.3e-08	0.60	0.97	0.03	FALSE
5	GTEx	Artery Tibial	IPO8	0.17	0.14	lasso	4	0.14	4.5e-11	5.1	-5.6	2.4e-08	0.67	0.67	0.33	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	IPO8	0.21	0.23	lasso	12	0.22	8.0e-28	5.1	-5.5	3.3e-08	0.60	1.00	0.00	FALSE
20	The Cancer Genome Atlas	Stomach Adenocarcinoma	IPO8	0.04	0.04	enet	7	0.02	8.1e-03	5.1	-5.5	3.6e-08	0.55	0.18	0.22	FALSE
19	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IPO8	0.09	0.05	blup	64	0.03	2.9e-02	5.1	-5.5	4.1e-08	0.56	0.11	0.14	FALSE
3	GTEx	Adipose Visceral Omentum	IPO8	0.17	0.08	lasso	2	0.05	9.9e-04	5.4	-5.4	8.5e-08	0.53	0.27	0.63	FALSE
6	GTEx	Breast Mammary Tissue	IPO8	0.11	0.11	lasso	10	0.08	4.3e-05	5.1	-5.3	1.0e-07	0.58	0.19	0.77	FALSE
10	GTEx	Heart Left Ventricle	IPO8	0.14	0.00	lasso	7	0.03	8.6e-03	-7.5	-5.3	1.4e-07	0.81	0.03	0.88	FALSE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	IPO8	0.06	0.06	blup	64	0.05	6.2e-04	5.1	-5.2	1.5e-07	0.52	0.28	0.16	FALSE
8	GTEx	Colon Transverse	IPO8	0.11	0.11	lasso	2	0.10	2.4e-05	5.1	-5.2	2.4e-07	0.54	0.46	0.50	FALSE
1	CommonMind	Brain Pre-frontal Cortex	IPO8	0.22	0.28	lasso	8	0.29	1.0e-35	5.1	-5.1	2.6e-07	0.53	1.00	0.00	FALSE