TWAS
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About
Usage
Models
Genes
Traits
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Traits
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Forced expiratory volume in 1-second (FEV1)
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chr22:17,581,838-19,203,078
Best TWAS P=1.57e-11 · Best GWAS P=4.96e-11 conditioned to 0.386
17.6M
17.8M
18M
18.2M
18.4M
18.6M
18.8M
19M
19.2M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Cells EBV-transformed lymphocytes
MICAL3
0.23
0.06
lasso
4
0.03
2.7e-02
6.6
-6.7
1.6e-11
-0.93
0.01
0.91
TRUE
2
GTEx
Thyroid
MICAL3
0.18
0.13
enet
18
0.13
6.5e-10
-5.3
-6.2
6.6e-10
-0.74
0.36
0.64
FALSE
4
The Cancer Genome Atlas
Thyroid Carcinoma
MICAL3
0.10
0.09
enet
14
0.10
1.4e-09
-5.3
-5.5
3.4e-08
-0.69
0.39
0.61
FALSE
3
The Cancer Genome Atlas
Kidney Renal Papillary Cell Carcinoma
MICAL3
0.10
0.06
enet
14
0.04
1.5e-03
6.4
-5.4
5.8e-08
-0.80
0.02
0.96
FALSE