Hub : Genes

MICAL3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.235	0.0870	8.3e-03	0.057	NA	0.025	NA	0.035	6.3e-03	NA	5.0e-02	NA	2.7e-02
2	GTEx	Cells Transformed fibroblasts	0.117	0.0420	2.6e-03	0.037	NA	0.071	NA	0.060	8.9e-04	NA	5.3e-06	NA	2.5e-05
3	GTEx	Nerve Tibial	0.259	0.0645	7.6e-05	0.114	NA	0.077	NA	0.098	1.9e-08	NA	4.3e-06	NA	1.9e-07
4	GTEx	Thyroid	0.182	0.0430	1.0e-06	0.133	NA	0.127	NA	0.125	2.3e-10	NA	6.5e-10	NA	8.7e-10
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.104	0.0460	3.4e-03	0.058	0.023	0.044	NA	0.033	3.1e-04	1.7e-02	1.5e-03	NA	5.1e-03
6	TCGA	Ovarian Serous Cystadenocarcinoma	0.118	0.0470	2.1e-03	-0.003	0.034	0.004	NA	-0.003	6.7e-01	2.3e-03	1.6e-01	NA	6.8e-01
7	TCGA	Thyroid Carcinoma	0.098	0.0310	4.3e-07	0.089	0.068	0.096	NA	0.061	5.1e-09	3.6e-07	1.4e-09	NA	1.4e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.7	1.2	2.9	1.2	0.0	-0.1	1.3	1.2	0.7	1.7
Bipolar Disorder or Schizophrenia	0.6	1.5	2.9	1.3	-0.4	0.4	1.5	1.5	1.1	1.7
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	0.3	-0.0	0.2	0.5	0.8	0.8	-0.1
Depression (Nagel 2018)	0.5	0.8	2.1	-0.6	-0.4	1.4	-0.2	0.7	1.5	-0.6
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.8	0.5	-1.7	-0.4	-0.4	-0.2	-0.7	0.3
Neuroticism (Nagel 2018)	0.2	0.4	1.4	-0.5	1.2	-0.1	-0.1	0.1	-0.8	-0.5
Schizophrenia (2018)	0.3	0.6	0.8	0.7	-0.5	0.6	0.9	0.9	0.8	0.8
Schizophrenia vs Biploar Disorder	1.1	1.5	2.7	-1.7	1.5	0.4	-1.6	-1.5	0.7	0.0
Worry (Nagel 2018)	0.2	0.5	1.7	-0.6	1.3	-0.5	-0.5	-0.0	-0.6	-0.8
Alzheimer’s Disease (in mother)	0.9	1.0	1.9	1.1	-1.4	0.1	0.7	1.3	0.8	1.1
Alzheimer’s Disease (in father)	1.0	1.1	6.2	0.9	-0.1	-2.5	-0.0	-0.0	0.9	0.1
Alzheimer’s Disease (including proxy)	0.4	0.6	3.7	0.3	-0.0	-1.9	0.2	0.3	0.4	0.4
Crohns Disease (2017)	0.8	1.7	2.6	1.6	-1.5	-0.3	1.5	1.1	1.0	1.5
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	0.5	-0.7	-0.2	0.4	0.2	0.7	0.6
Ulcerative Colitis (UC)	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.3	-0.3	-0.0	0.0
Major Depression (MDD)	1.3	1.5	3.6	1.9	-0.7	-0.5	1.1	1.1	1.7	1.2
Reaction Time	0.2	0.4	1.8	0.4	1.3	-0.8	0.2	0.5	-0.4	-0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.5	-0.4	-0.5	-1.1	-1.6	-0.1	-0.2	-0.9
Breast Cancer	0.2	0.4	1.7	-0.4	0.5	-1.3	-0.5	0.2	-0.6	-0.1
Ovarian Cancer	1.2	1.6	3.6	1.6	-0.0	-0.4	1.9	1.2	0.6	1.8
Prostate Cancer	0.5	0.7	2.2	-0.4	0.1	-1.5	-0.3	0.3	-1.1	-1.1
Age at First Birth	0.2	0.3	0.7	0.3	0.8	-0.6	0.4	0.0	0.5	0.5
Bipolar Disorder (2011)	0.4	0.4	1.9	0.0	0.0	0.0	0.0	1.0	-0.4	1.4
Body Mass Index (BMI) (2010)	0.6	0.8	2.6	1.1	-1.6	0.2	0.6	0.7	0.7	0.8
Coronary Artery Disease (CAD)	0.1	0.2	0.4	-0.6	0.6	-0.1	-0.6	-0.2	-0.2	-0.3
Crohns Disease (2012)	1.4	2.2	3.7	1.4	-1.8	-1.9	1.0	1.4	1.7	0.8
Mean Putamen Volume	0.5	0.6	1.1	-0.8	0.5	0.7	-0.9	-0.7	-1.1	-0.6
Fasting Glucose	0.5	0.6	1.3	1.1	-0.8	0.8	0.4	0.9	0.5	0.6
HbA1C	0.5	0.6	2.8	0.1	-1.7	0.8	0.5	-0.0	-0.4	0.5
HDL Cholesterol	0.2	0.4	1.2	0.4	0.2	0.4	0.6	0.6	-0.6	1.1
LDL Cholesterol	2.1	3.4	7.0	-2.6	0.5	0.6	-2.0	-2.2	-1.5	-2.2
Lupus	0.4	0.7	1.5	-0.3	-0.2	0.1	-1.2	-0.3	1.2	-1.2
Neuroticism (2016)	0.4	0.6	3.1	-0.5	0.9	-0.4	0.1	0.3	-1.8	0.3
Primary Biliary Cirrhosis	1.4	1.9	5.9	1.0	-1.8	0.0	0.4	1.7	2.4	0.1
Rheumatoid Arthritis	1.4	1.9	3.1	-1.7	-0.2	0.6	-1.8	-1.6	1.4	-1.4
Schizophrenia (2014)	0.2	0.3	1.2	0.3	0.4	0.2	0.6	0.5	1.1	0.5
Triglycerides	1.4	2.3	4.9	1.4	-2.0	-1.3	0.7	2.2	1.8	-0.2
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.3	1.1	-1.0	0.0	0.3	0.3	-1.0	0.6
Ulcerative Colitis	0.2	0.3	1.5	0.3	0.3	1.2	-0.5	-0.5	0.3	-0.4
Blood Eosinophil Count	0.3	2.3	8.9	-0.6	3.0	0.3	-1.5	-0.4	-1.8	-1.1
Blood Platelet Count	0.1	1.3	4.4	0.6	-2.1	0.7	-0.8	1.0	1.5	-0.2
Blood Red Count	0.8	7.9	15.4	3.1	-3.9	-0.7	3.3	2.2	0.7	3.7
Blood White Count	1.2	9.2	18.1	4.3	0.8	-1.7	3.5	3.6	-1.8	3.8
Heel T-Score	0.3	2.3	9.0	-0.8	-0.3	-0.3	-0.1	-3.0	-2.5	-0.3
BMI	1.0	5.6	20.5	2.4	-4.5	1.1	2.1	1.3	1.3	2.0
Height	0.5	10.3	18.8	4.3	-3.8	-0.3	3.1	3.8	-1.5	3.5
Waist Hip Ratio (WHR)	1.1	5.1	12.2	3.5	-1.2	-0.8	2.5	3.2	1.3	1.9
Systolic Blood Pressure	2.4	12.0	20.1	-4.4	2.8	1.7	-4.1	-4.5	0.4	-4.1
Smoking Status	1.2	2.9	6.8	1.7	-1.9	-1.0	2.6	1.0	-0.5	2.2
Allergy or Eczema	0.5	1.3	2.5	1.3	1.2	-0.1	1.6	1.5	-0.0	1.1
Cardiovascular Disease	1.3	4.2	8.1	-2.1	1.7	1.2	-2.8	-2.9	-0.2	-2.3
Hypothyroidism (self reported)	0.9	2.0	4.6	-1.8	0.8	-0.8	-2.1	-1.2	0.6	-1.7
Respiratory disease	0.6	1.4	4.1	1.6	-0.8	-1.0	1.0	2.0	0.2	0.8
Type 2 Diabetes (T2D) (2018)	2.3	4.3	7.2	2.7	-2.1	-0.4	2.3	2.6	2.0	1.4
Lung FEV1/FVC ratio	11.4	57.8	114.5	-10.0	3.5	4.0	-10.7	-7.8	1.5	-9.9
Lung FVC	7.0	35.6	67.6	-8.2	5.5	1.9	-6.5	-8.2	-0.4	-6.3
Neuroticism	0.2	0.5	1.1	0.2	0.9	-0.8	1.0	0.8	-0.6	0.6
Chronotype (morning person)	1.4	3.3	7.5	-1.5	2.3	2.7	-0.4	-2.7	-1.0	-0.4
Hair Pigment	0.1	3.0	6.0	1.7	-0.2	-1.2	2.4	1.7	1.6	2.4
Tanning	0.2	2.9	5.7	-1.5	1.5	0.5	-2.2	-2.4	-1.1	-1.9
Hand grip strength (left)	0.7	1.9	7.4	0.4	-2.7	-1.3	0.8	0.8	-1.1	1.2
Number of treatments/medications taken	0.2	0.3	1.1	0.1	0.7	0.7	-0.5	-0.1	-0.2	-1.0
Average weekly spirits intake	1.4	1.8	3.8	-1.8	-0.1	1.6	-1.6	0.2	-0.1	-2.0
Sensitivity / hurt feelings	0.2	0.3	0.9	-0.1	0.2	0.0	-0.3	0.6	-1.0	-0.8
Frequency of depressed mood in last 2 weeks	0.5	0.8	3.0	-0.3	-0.2	1.1	-0.3	0.6	1.7	-0.8
Hearing difficulty/problems: Yes	0.7	1.1	2.1	1.4	-0.4	0.4	1.2	1.5	-0.0	1.3
Relative age of first facial hair	0.9	1.9	3.2	-1.1	0.5	1.4	-1.7	-1.1	-1.8	-1.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.1	0.9	1.0	0.3	0.9	-0.0	-0.7	0.2
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.7	0.7	-0.5	0.5	0.2	0.5	0.8	0.7
Ever had hysterectomy (womb removed)	2.1	2.3	6.0	1.5	-1.0	-2.1	1.1	2.4	-0.2	1.1
Systolic blood pressure, automated reading	1.7	4.9	8.2	-2.3	1.0	2.3	-2.8	-2.9	-0.6	-2.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.2	-0.2	0.5	1.1	-0.4	-0.3	-0.9	-0.2
Angina	0.7	1.0	1.9	-1.4	1.2	0.2	-1.1	-1.0	0.5	-1.0
Medication for hormone replacement therapy	0.2	0.2	0.5	0.1	0.5	-0.7	-0.7	0.0	0.4	-0.2
Vitamin and mineral supplements	0.1	0.2	0.5	0.5	-0.6	-0.7	-0.1	-0.2	-0.1	-0.4
Supplements: Zinc	0.6	0.7	1.6	0.8	0.0	-0.9	1.3	0.7	0.2	1.0
Medication: Co-codamol	0.7	0.8	1.6	0.6	1.3	-0.7	1.1	-0.6	-0.7	1.1
Medication: Metformin	3.9	5.5	10.4	2.8	-1.6	-0.5	2.9	3.2	1.9	2.3
Diabetes (father)	2.0	2.5	8.1	1.9	-1.2	0.8	1.3	0.9	2.8	1.1
Diabetes (mother)	0.6	0.7	2.1	0.4	-1.4	0.3	-0.2	0.9	1.5	-0.3
Severe depression (siblings)	0.4	0.5	1.6	0.7	-0.3	-0.4	0.8	1.3	-0.2	0.6
Pack years adult smoking proportion	1.0	1.5	5.3	0.5	-1.1	-0.7	0.4	2.3	1.8	0.1
Impedance of leg (right)	0.5	2.5	5.1	-2.3	1.5	0.1	-2.1	-1.4	0.2	-2.0
Leg fat-free mass (left)	1.3	7.1	18.7	3.1	-4.3	-0.7	2.6	2.8	0.3	2.3
Trunk fat percentage	0.6	2.3	7.8	2.0	-2.8	1.0	1.4	1.0	-0.0	0.9
Hand grip strength (right)	0.9	2.4	5.2	1.0	-2.0	-1.3	1.3	0.8	-2.3	1.7
Townsend deprivation index at recruitment	0.4	0.6	0.9	0.5	-0.3	0.9	0.9	0.8	1.0	0.6
Current tobacco smoking	0.3	0.5	1.3	1.0	-0.6	-0.6	1.1	-0.0	0.4	0.7
Average weekly fortified wine intake	0.4	0.4	1.5	-0.4	-0.5	0.3	-0.3	-1.2	-1.0	-0.1
Maternal smoking around birth	0.1	0.2	0.5	-0.2	-0.4	0.3	-0.4	0.4	-0.7	-0.1
Fed-up feelings	0.0	0.1	0.3	0.2	-0.2	0.0	0.2	0.2	-0.6	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.9	0.4	-0.8	0.8	0.3	1.3	1.4	0.1
Relative age voice broke	2.3	3.6	7.0	-2.2	0.7	1.7	-2.6	-1.8	-0.3	-2.4
Taking other prescription medications	0.1	0.2	0.6	0.7	0.8	0.2	0.2	0.1	0.1	-0.1
Age when periods started (menarche)	0.6	1.5	3.3	-1.6	1.8	0.8	-1.2	-0.8	-0.5	-1.3
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	3.1	1.1	-1.7	-0.7	1.1	0.5	-0.3	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.4	-0.2	0.5	0.1	-0.2	-0.7	-0.1	-0.5
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	3.6	-0.3	1.8	-1.9	-0.3	-0.2	-1.9	-0.2
Qualifications: CSEs or equivalent	0.2	0.2	0.8	0.3	0.2	0.5	0.4	0.6	-0.9	-0.1
Serious illness, injury or assault to yourself	1.0	1.2	3.1	-0.8	1.2	0.8	-1.0	-0.3	1.3	-1.8
High blood pressure	1.5	4.1	6.9	-1.8	1.5	2.6	-2.2	-2.6	-0.6	-2.1
Hayfever, allergic rhinitis or eczema	0.8	1.8	4.4	1.5	-0.1	-0.7	1.9	2.1	0.2	1.2
Multivitamins +/- minerals	0.4	0.5	1.8	0.2	-0.0	0.4	0.7	1.4	0.4	1.0
Stomach or abdominal pain in last month	2.5	3.2	5.3	2.1	-1.5	-1.3	1.9	2.3	1.5	1.7
Supplements: Glucosamine	0.7	0.9	2.0	1.3	-0.6	1.4	0.9	0.8	-0.5	0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.4	-0.1	-0.6	-1.0	0.6	1.2	-0.9	0.3
Medication: Atenolol	1.5	1.9	4.8	-2.2	0.0	1.1	-1.4	-2.0	-0.3	-1.2
Medication: Levothyroxine sodium	2.0	3.3	6.2	-1.9	1.9	-1.5	-2.4	-1.3	-0.3	-2.5
Sitting height	0.5	3.6	9.8	2.2	-3.1	-0.3	1.7	2.2	-0.1	1.7
Chronic bronchitis/emphysema (father)	5.7	6.6	12.7	3.0	-2.4	-1.4	3.1	2.6	-0.9	3.6
High blood pressure (mother)	0.6	0.9	2.9	0.2	-0.1	1.6	-0.2	-1.7	-0.5	-0.6
Body mass index (BMI)	0.8	3.3	9.0	2.4	-3.0	0.5	1.9	1.6	0.8	1.3
Impedance of leg (left)	0.9	4.5	8.6	-2.9	2.1	0.8	-2.6	-2.2	-0.2	-2.5
Leg predicted mass (left)	1.3	6.7	18.4	3.1	-4.3	-0.6	2.5	2.8	0.3	2.2
Trunk fat mass	1.0	4.1	13.5	2.6	-3.7	0.5	1.8	1.8	0.3	1.3
Waist circumference	1.5	5.5	11.0	3.3	-3.2	0.1	2.5	2.7	0.8	1.8
Number of incorrect matches in round	0.9	1.5	5.1	-0.5	2.3	1.1	1.0	-1.3	-1.2	0.3
Past tobacco smoking	1.1	2.0	5.0	-1.4	0.9	0.5	-2.2	-0.8	1.5	-1.8
Alcohol usually taken with meals	1.8	2.8	12.6	-0.4	1.7	1.0	-0.3	-1.7	-3.5	-0.2
Nervous feelings	0.3	0.5	1.1	1.0	-0.4	0.2	0.4	1.0	1.0	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.5	1.3	-0.7	0.1	0.6	1.6	0.5	0.7
Hearing difficulty/problems with background noise	0.8	1.2	2.8	1.3	0.3	-0.7	1.7	1.5	-0.1	1.1
Hair/balding pattern: Pattern 2	0.7	0.9	5.6	-0.2	-0.8	2.4	0.3	0.0	0.3	-0.4
Had menopause	0.2	0.2	0.6	0.3	-0.4	0.7	0.4	0.2	-0.2	0.8
Had other major operations	2.3	2.8	7.2	1.1	-2.4	-2.7	1.0	1.5	0.4	1.4
Forced vital capacity (FVC)	2.3	8.9	18.0	-4.2	2.5	1.1	-3.4	-4.0	-1.2	-2.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.4	-1.0	0.2	0.2	-1.0	-1.1	-0.1	-1.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.0	0.5	0.6	-0.7	0.9	-0.1	-1.4	0.7
Qualifications: None of the above	0.6	1.3	3.0	1.2	-1.2	0.3	1.2	0.9	1.7	0.7
Financial difficulties in last 2 years	2.3	3.1	6.0	-1.9	1.9	-1.0	-2.0	-1.9	0.4	-2.4
Mouth/teeth dental problems	0.8	1.2	2.6	0.5	-1.6	-1.2	0.4	0.6	1.4	1.1
Heart attack	0.6	0.8	3.1	0.7	0.9	0.7	0.6	0.4	1.8	0.2
Allergy	0.9	2.0	5.2	-1.7	0.6	0.9	-1.8	-2.3	-0.9	-0.9
Pain all over the body in last month	0.5	0.5	1.1	1.0	-1.0	0.2	0.7	-0.1	0.2	0.9
Diabetes (self-reported)	1.3	2.0	4.3	1.8	-1.1	-0.1	1.9	2.1	1.1	1.0
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	5.0	-0.4	1.4	-2.2	-0.3	0.0	-0.6	-0.1
Medication: Ramipril	0.8	1.0	5.7	0.3	2.4	0.0	0.3	0.8	-0.4	0.2
Medication: Simvastatin	1.0	1.4	3.8	-1.3	-0.0	0.9	-1.5	-0.4	1.1	-2.0
Fluid intelligence score	0.2	0.5	2.1	0.5	-0.4	-0.7	-0.1	-0.4	-1.5	0.2
Illnesses of siblings	0.5	0.7	1.5	-0.5	-0.6	1.0	-1.2	-1.1	-0.5	-0.3
Neuroticism score	0.3	0.7	1.7	0.6	0.4	-1.0	1.1	1.3	-0.3	0.7
Weight	1.4	7.0	19.1	3.3	-4.4	0.0	2.6	2.7	0.6	2.1
Impedance of arm (right)	0.2	0.8	3.0	-0.1	1.4	-0.8	-0.1	0.2	-1.7	-0.1
Arm fat percentage (right)	0.9	3.6	7.6	2.8	-2.6	-0.2	2.3	1.9	0.2	1.4
Trunk fat-free mass	0.9	5.4	15.0	2.2	-3.9	-1.1	2.1	2.9	1.0	1.7
Hip circumference	0.6	2.7	10.2	1.8	-3.2	0.6	1.5	1.6	-0.1	0.8
Time employed in main current job	1.0	1.1	3.4	-0.6	1.1	0.7	-0.5	-1.8	-1.2	-0.8
Alcohol intake versus 10 years previously	2.4	3.6	9.5	2.1	-0.6	-0.2	3.1	2.0	0.3	2.6
Father’s age at death	0.5	0.6	1.7	0.7	-1.2	0.3	0.2	-0.4	1.3	0.6
Worrier / anxious feelings	0.2	0.3	1.5	-0.2	1.2	-0.4	-0.2	-0.2	-0.6	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.2	1.1	-0.8	1.1	1.0	1.0	1.1	0.1
Falls in the last year	0.8	1.1	3.9	-0.4	0.9	2.0	-0.0	-0.6	1.5	-0.3
Hair/balding pattern: Pattern 3	0.4	0.6	2.3	0.6	0.2	-1.5	0.0	0.6	-0.4	1.1
Number of live births	0.2	0.3	1.3	0.1	-1.1	-0.4	0.5	0.3	0.4	0.4
Forced expiratory volume in 1-second (FEV1)	6.5	22.0	45.4	-6.7	2.8	1.6	-6.2	-5.4	-0.3	-5.5
Pulse rate	0.5	0.9	4.2	0.2	-0.8	0.7	-0.3	0.4	2.0	-0.9
Happiness	1.5	1.9	4.8	2.0	0.5	0.2	2.2	1.1	-0.3	1.6
Noisy workplace	0.9	1.1	1.8	1.1	0.0	1.3	1.1	1.3	1.1	0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.0	-0.6	0.5	0.9	-1.0	-0.3	0.8	-0.4
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.5	5.1	2.3	-1.5	-0.7	1.6	1.1	1.0	2.2
Mouth/teeth dental problems: Dentures	1.1	1.9	8.1	-0.6	0.6	2.8	-0.0	-0.8	-1.9	-0.7
Asthma	0.6	1.2	3.1	1.8	-0.8	-0.7	1.0	1.6	0.4	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.8	-0.3	0.2	0.5	-0.0	-1.2	-1.3	-0.2
Medication: Cholesterol lowering	0.4	0.6	1.3	-0.9	0.9	0.5	-0.2	-1.1	0.7	-0.8
Depression (self-reported)	0.5	0.6	1.0	-0.5	1.0	-0.4	-0.5	-1.0	0.9	-0.8
Medication: Lansoprazole	0.6	0.7	2.4	1.5	0.4	0.7	0.9	-0.0	0.1	0.9
Prospective memory result	0.7	0.9	1.9	0.8	-0.9	-1.4	0.6	1.3	0.8	0.3
Lung cancer (father)	0.0	0.1	0.1	0.3	-0.2	0.3	-0.2	0.1	-0.1	-0.2
Illnesses of mother	0.9	1.2	2.0	-1.4	1.2	-0.8	-1.4	0.4	-1.1	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	7.3	23.4	45.8	-6.8	3.1	1.4	-6.6	-5.4	-0.1	-5.9
Pulse wave Arterial Stiffness index	0.6	0.7	1.7	-0.7	-1.2	1.3	-0.3	-1.2	-0.2	-0.3
Impedance of arm (left)	0.3	1.2	3.4	-0.4	1.6	0.3	-0.8	-1.0	-1.8	-0.5
Arm fat mass (right)	1.4	5.7	14.1	3.1	-3.8	0.1	2.6	2.4	0.7	1.8
Trunk predicted mass	0.9	5.2	14.7	2.1	-3.8	-1.0	2.0	2.8	1.0	1.6
Standing height	0.5	4.6	12.5	2.2	-3.5	-0.7	1.7	2.8	-0.5	1.8
Length of working week for main job	0.4	0.4	0.6	-0.6	0.8	-0.7	-0.5	-0.6	-0.5	-0.8
Exposure to tobacco smoke at home	1.8	2.0	4.1	1.2	-2.0	1.3	1.3	1.0	0.1	2.0
Breastfed as a baby	0.3	0.3	0.6	0.7	-0.3	-0.6	0.8	0.4	0.3	0.6
Tense / ‘highly strung’	0.3	0.5	1.3	0.0	0.2	-1.2	-0.1	1.0	0.9	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.1	1.3	-0.0	-0.8	1.4	1.3	0.6	1.5
Hair/balding pattern: Pattern 4	1.2	2.9	6.0	-2.1	1.2	-0.3	-1.8	-2.4	0.3	-2.2
Birth weight of first child	0.6	1.0	3.7	-0.8	1.0	1.0	0.5	-0.5	-1.9	0.5
Peak expiratory flow (PEF)	1.0	2.4	4.8	-2.2	-0.7	-0.6	-1.9	-1.9	0.0	-2.0
Pulse wave reflection index	0.7	0.8	1.4	-0.1	-0.8	0.8	1.1	-1.2	-1.1	0.8
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.6	-0.6	0.3	0.3	-0.2	-0.6	-0.8	-0.2
Loud music exposure frequency	4.7	5.1	9.8	2.7	-1.7	-0.2	3.1	2.4	1.0	3.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	3.3	-1.1	1.0	0.1	-1.1	-0.9	-1.8	-0.9
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	1.8	-0.8	1.1	-0.7	-0.8	-1.0	-1.3	-1.2
Blood clot in the leg (DVT)	0.1	0.1	0.3	0.1	0.3	-0.6	0.5	0.1	0.5	-0.0
Medication: Paracetamol	0.7	1.2	4.7	-1.2	-0.5	0.3	-1.2	-0.9	0.1	-2.2
Headache pain in last month	2.1	3.5	9.0	-2.1	1.3	-0.2	-2.7	-1.5	-0.0	-3.0
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	3.5	1.7	-1.5	-0.8	1.3	1.9	-0.4	1.6
Glaucoma (self-reported)	4.2	4.9	12.5	1.8	-1.2	-2.3	2.4	3.5	0.6	2.3
Gout (self-reported)	1.5	2.0	5.8	-0.7	2.1	1.3	-0.1	-2.4	-1.3	-0.2
Hypothyroidism/myxoedema (self-reported)	2.0	3.9	7.7	-2.4	1.8	-0.9	-2.8	-1.6	0.7	-2.6
Medication: Amlodipine	0.2	0.2	1.2	0.3	-0.2	-0.1	0.3	0.1	1.1	0.4
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.6	0.9	-1.9	1.0	0.8	0.5	0.7	0.5
Birth weight	0.9	2.0	3.3	1.7	-1.8	-0.9	1.8	1.5	0.2	1.3
Chronic bronchitis/emphysema (mother)	1.6	1.9	4.3	1.6	-0.5	-0.8	1.8	1.5	0.4	2.1
High blood pressure (siblings)	0.4	0.6	2.4	0.8	-0.5	-0.1	1.5	0.3	0.8	0.6
Forced vital capacity (FVC), Best measure	2.9	10.5	19.8	-4.4	2.6	1.1	-4.1	-3.9	-0.7	-3.6
Body fat percentage	0.6	2.3	7.4	2.1	-2.7	0.7	1.4	1.1	0.4	0.8
Leg fat percentage (right)	0.6	2.3	7.1	2.0	-2.7	-0.4	1.3	1.3	1.1	0.7
Arm fat-free mass (right)	0.9	4.4	15.3	2.0	-3.9	-0.1	1.6	2.3	1.2	1.4
Exposure to tobacco smoke outside home	1.3	1.7	3.4	1.2	-1.4	1.3	1.8	1.2	0.2	1.3
Comparative body size at age 10	2.1	5.7	10.2	3.2	-3.0	1.1	3.0	1.9	1.2	2.3
Number of full brothers	2.1	2.7	8.3	0.7	-0.4	-2.7	0.6	2.9	1.5	0.2
Worry too long after embarrassment	0.1	0.2	0.8	-0.2	0.4	-0.3	0.2	0.6	-0.9	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	5.6	1.2	0.7	-0.8	1.8	-0.4	-0.9	2.4
Wheeze or whistling in the chest in last year	0.7	1.3	3.7	1.6	0.0	0.1	0.9	1.9	0.9	0.9
Number of children fathered	0.3	0.3	0.5	0.7	-0.1	0.7	0.0	-0.7	0.7	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.4	-0.6	-0.6	-0.5	0.4	-0.3	-0.5	0.6
Age at first live birth	0.8	1.4	6.1	-0.0	-0.9	-2.5	0.2	-0.0	1.6	0.3
Pulse wave peak to peak time	0.7	0.9	2.0	0.9	1.0	-1.4	0.5	1.4	0.2	0.5
Health satisfaction	1.1	1.5	4.2	-1.0	1.0	2.0	-0.7	-1.3	-0.7	-1.1
Shortness of breath walking on level ground	0.4	0.5	1.1	0.5	1.1	-0.1	0.9	0.6	-0.6	0.5
Qualifications: College or University degree	0.1	0.4	1.6	0.0	0.3	-1.3	-0.6	-0.8	0.1	0.1
Eye problems/disorders: None of the above	0.3	0.4	1.9	0.5	-0.7	0.2	-0.2	-1.4	0.1	-0.2
Mouth/teeth dental problems: Loose teeth	0.6	0.8	2.2	1.0	-0.4	1.1	0.6	0.3	1.5	0.5
Emphysema/chronic bronchitis	1.2	1.3	3.9	0.7	-0.5	0.8	2.0	1.2	1.1	1.2
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	0.1	-0.0	-0.9	0.4	0.6	0.8	0.4
Neck or shoulder pain in last month	2.0	2.8	5.1	-0.9	2.3	1.8	-1.8	-1.1	-0.8	-2.2
Medication: Blood pressure	1.6	2.8	4.7	-2.0	1.9	0.8	-1.6	-2.2	-0.4	-2.0
Angina (self-reported)	0.8	1.1	2.2	-1.5	1.1	0.3	-1.1	-1.1	0.5	-1.0
Migraine (self-reported)	1.5	1.9	3.8	-1.1	1.7	-0.7	-2.0	-0.8	-0.9	-1.8
Medication: Ibuprofen	0.7	0.8	3.0	-0.2	-0.2	0.6	0.1	-1.4	-1.7	-0.3
Medication: Allopurinol	0.9	1.1	3.2	-0.8	0.6	1.7	-0.6	-1.8	0.2	-0.7
Medication: Omeprazole	0.6	0.7	2.1	1.4	-0.4	0.5	0.6	0.4	0.1	1.5
Medication: Seretide 50 evohaler	0.6	0.6	1.2	-0.1	1.1	0.9	0.7	-0.1	-1.1	0.9
Mean time to correctly identify matches	0.3	0.5	3.2	0.1	1.8	-0.7	0.2	0.0	-0.4	-0.1
Heart disease (mother)	0.3	0.4	0.8	-0.1	0.7	0.9	-0.1	-0.1	0.8	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.4	-0.2	-0.6	-0.2	0.3	-0.4	0.5	-0.2
Whole body fat mass	1.1	4.7	14.3	2.8	-3.8	0.4	2.1	1.9	0.6	1.5
Leg fat mass (right)	1.1	4.3	13.4	2.7	-3.7	0.0	1.8	1.8	1.0	1.3
Arm predicted mass (right)	0.9	4.5	15.6	2.0	-3.9	-0.1	1.7	2.4	1.2	1.3
Pulse rate, automated reading	0.4	1.4	3.9	1.5	-1.0	-0.1	1.3	2.0	0.8	0.6
Alcohol intake frequency.	0.6	1.4	2.8	1.1	-0.9	-1.1	1.4	1.7	-0.5	1.3
Comparative height size at age 10	2.2	11.9	22.9	4.8	-3.6	-1.1	3.7	4.2	0.6	3.8
Number of full sisters	0.9	1.0	3.9	-0.6	0.0	-0.1	-0.8	-0.3	2.0	-1.5
Suffer from ‘nerves’	0.3	0.5	1.2	0.7	-0.7	-0.2	0.4	1.1	0.8	0.6
Overall health rating	0.1	0.3	0.9	0.7	0.9	0.1	0.7	0.5	-0.0	0.1
Chest pain or discomfort	0.8	1.2	4.2	0.9	-0.1	-1.0	0.3	2.0	1.5	0.2
Had major operations	0.2	0.2	0.5	-0.6	0.1	0.2	-0.6	-0.0	-0.7	-0.4
Age at last live birth	0.6	0.8	2.0	-1.4	-0.2	-0.5	-0.5	-1.4	1.0	-0.5
Family relationship satisfaction	1.0	1.2	2.3	1.4	-0.6	0.6	1.5	0.9	-1.5	0.8
Leg pain on walking	1.3	1.6	8.0	-0.1	0.9	2.8	-0.8	-0.4	0.1	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.3	-0.4	0.3	-1.5	-0.3	1.0	-1.4	0.7
Commuting to job workplace: Car/motor vehicle	1.9	2.2	4.4	1.7	-0.7	-1.6	1.7	1.5	0.1	2.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.8	-0.3	0.4	-0.0	-0.4	1.4	-0.6	0.1
Medication: Aspirin	0.2	0.3	0.8	0.4	0.3	0.2	0.6	0.1	-0.7	0.9
Supplements: Vitamin C	0.5	0.6	1.4	0.8	0.0	-0.3	0.7	1.2	0.9	0.7
Knee pain experienced in last month	0.3	0.5	0.9	0.8	0.1	1.0	0.2	0.8	-0.8	-0.5
Hypertension (Self-reported)	1.9	5.2	8.8	-2.2	1.8	2.6	-2.6	-3.0	-0.6	-2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.7	0.7	0.2	0.3	0.6	0.0	-1.6	0.8
Illnesses of father: Heart disease	0.4	0.5	1.2	-0.7	0.6	0.3	-0.8	-1.0	-0.2	-1.1
Illnesses of siblings: Diabetes	2.4	3.0	7.6	2.0	0.3	-1.1	1.8	2.8	1.5	1.4
Smoking status: Previous	0.9	1.3	2.8	0.8	-1.2	0.1	1.7	0.8	-0.9	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.3	0.9	-1.8	-1.0	0.1	1.5	0.4	0.2
Whole body fat-free mass	1.0	5.8	17.2	2.5	-4.1	-0.8	2.2	2.8	0.8	1.9
Leg fat-free mass (right)	1.1	5.7	15.8	2.7	-4.0	-0.3	2.4	2.6	0.1	2.2
Arm fat percentage (left)	0.7	2.7	6.9	2.4	-2.6	0.2	1.7	1.4	0.2	1.1
Average weekly red wine intake	0.4	0.6	1.4	-1.2	0.3	0.6	-0.8	-1.1	-0.9	-0.0
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.7	-0.9	0.2	-0.5	-0.6	-0.1	-0.8	-0.6
Mood swings	0.3	0.6	2.2	0.1	1.1	1.5	0.6	0.0	0.6	-0.0
Loneliness, isolation	2.3	3.1	6.9	2.0	-1.5	-1.2	1.2	2.6	2.3	0.8
Long-standing illness, disability or infirmity	0.7	1.0	2.1	1.2	1.4	-0.1	1.1	0.4	1.4	0.5
Ever had bowel cancer screening	0.5	0.5	1.2	1.0	0.3	-0.9	0.8	-0.0	0.3	1.1
Diabetes diagnosed by doctor	3.0	4.8	9.6	2.8	-1.6	-0.4	2.6	3.1	2.0	1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.0	-0.1	-0.5	-1.4	1.0	0.2	0.2	1.3
Friendships satisfaction	3.0	3.7	7.2	2.0	-0.6	1.6	2.4	1.9	-1.6	2.7
Qualifications: nursing, teaching	0.3	0.5	2.6	0.0	-0.3	1.6	-0.7	-0.3	0.1	-0.1
Commuting to job workplace: Walk	3.1	3.3	7.1	-1.6	1.2	1.7	-2.7	-1.4	1.0	-2.4
Eye problems/disorders: Cataract	0.3	0.4	1.2	-0.8	0.2	-0.6	-0.2	1.1	0.2	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.3	1.1	0.7	1.1	1.0	-0.7	0.0	0.8
Medication for cholesterol	1.6	2.5	5.2	1.3	-1.7	-1.5	2.3	1.3	-0.9	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.7	-0.0	0.4	1.3	-0.2	-0.5	0.5	-0.1
Back pain experienced in last month	1.3	1.8	7.3	0.9	-0.6	2.7	0.7	-0.3	1.9	-0.2
Mineral and other dietary supplements	0.5	0.7	1.9	-0.8	-0.4	-1.4	-0.9	0.1	0.5	-1.0
Breast cancer (self-reported)	1.2	1.5	5.1	0.5	-0.5	-0.3	2.0	0.3	-0.8	2.3
Asthma (self-reported)	0.5	1.0	2.4	1.5	-0.8	-0.8	0.8	1.6	0.4	0.3
Osteoporosis (self-reported)	0.8	1.0	2.9	0.7	0.5	-0.1	1.7	0.8	-1.3	1.2
Osteoarthritis (self-reported)	2.1	2.8	5.5	-1.2	2.3	1.2	-1.3	-2.0	-1.8	-1.5
Medication: Aspirin	0.4	0.5	1.7	0.7	0.2	0.6	0.9	0.4	-0.5	1.3
Medication: Gliclazide	2.0	2.3	4.1	2.0	-0.2	-0.9	1.6	1.8	1.8	1.5
Illnesses of father: None of the above (group 1)	1.4	1.7	3.4	-1.6	1.7	0.5	-1.9	-0.3	-0.1	-1.7
Smoking status: Current	0.3	0.5	1.6	1.0	-0.3	-0.5	1.3	0.0	0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	13.7	29.0	53.2	-7.1	3.7	3.2	-6.4	-7.3	0.8	-5.9
Whole body water mass	1.1	6.3	17.1	2.6	-4.1	-0.8	2.4	3.0	0.9	2.0
Leg predicted mass (right)	1.1	5.9	16.2	2.8	-4.0	-0.4	2.4	2.6	0.1	2.2
Arm fat mass (left)	1.2	5.1	13.5	3.0	-3.7	0.5	2.3	2.2	0.6	1.5
Number of self-reported non-cancer illnesses	0.3	0.4	1.1	0.4	1.0	-0.1	-0.4	-0.6	0.6	-1.0
Average weekly champagne plus white wine intake	0.2	0.2	1.0	-0.2	-0.3	-1.0	-0.1	-0.3	0.4	-0.5
Miserableness	0.5	0.9	2.3	1.3	-0.7	-0.9	1.0	1.5	0.2	0.6
Guilty feelings	1.0	1.5	3.8	-1.5	1.7	0.2	-0.8	-1.9	-0.3	-0.9
Wears glasses or contact lenses	0.4	0.4	1.3	0.5	0.3	-0.0	0.6	1.1	-0.7	0.8
Ever taken oral contraceptive pill	0.8	0.9	1.6	-1.0	-0.3	-1.3	-1.1	-0.9	-0.7	-0.9
Hearing aid user	0.9	1.0	2.2	1.1	-1.1	-1.3	-0.0	1.5	1.0	0.1
Mother’s age at death	0.8	1.0	4.6	0.6	0.4	-2.2	0.6	0.7	-0.4	0.9
Financial situation satisfaction	0.6	0.8	2.3	0.2	-0.3	1.5	0.1	-1.3	-0.9	-0.7
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.8	1.3	-0.4	0.0	1.7	0.9	-0.9	1.4
Commuting to job workplace: Public transport	3.5	4.2	10.5	-1.8	3.2	-0.5	-2.0	-1.7	-1.9	-2.2
Eye problems/disorders: Glaucoma	2.2	2.6	8.0	1.3	-0.9	-1.9	1.5	2.8	0.2	1.4
Medication: Blood pressure	0.6	1.1	2.6	-0.7	1.3	1.6	-0.9	-1.4	-0.4	-0.3
Pain type(s) experienced in last month: Hip pain	0.9	1.1	4.5	-0.3	2.1	-0.4	-0.9	0.4	0.7	-1.2
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.7	1.0	0.1	0.8	1.0	0.3	-0.5	1.3
High cholesterol (Self-reported)	0.9	1.7	3.7	-1.9	1.0	0.1	-1.7	-1.1	0.4	-1.7
Medication: Bendroflumethiazide	1.5	2.3	4.5	-1.6	1.5	2.1	-1.3	-1.7	-1.0	-1.1
Medication: Paracetamol	1.1	1.6	5.7	-1.4	0.3	0.4	-1.4	-1.2	-0.0	-2.4
Medication: Lisinopril	2.4	3.2	10.8	-1.9	1.2	1.7	-0.8	-3.3	-1.1	-1.2
Medication: Atorvastatin	0.3	0.3	1.0	-0.3	0.4	-0.8	0.6	-0.0	0.1	1.0
Illnesses of father: High blood pressure	0.4	0.5	1.4	-0.9	-0.8	0.2	-0.1	-1.2	-0.8	-0.3
Alcohol drinker status: Never	0.1	0.1	0.3	0.2	-0.1	0.5	-0.1	0.3	-0.0	-0.1
Ever smoked	0.9	1.5	4.4	0.8	0.4	-0.9	1.6	-0.1	-2.1	1.4
Basal metabolic rate	1.2	6.5	19.0	2.7	-4.4	-0.6	2.4	2.9	0.8	1.9
Leg fat percentage (left)	0.5	1.8	6.6	1.7	-2.6	-0.1	1.0	0.9	0.9	0.5
Arm fat-free mass (left)	1.2	6.0	15.9	2.5	-4.0	-0.2	2.5	3.0	0.9	1.8
Number of operations (self-reported)	2.1	3.1	6.0	1.2	-1.5	-2.3	1.6	1.7	-1.0	2.5
Average weekly beer plus cider intake	1.8	2.5	5.3	1.0	0.5	-2.3	1.2	1.8	2.1	1.4
Irritability	0.1	0.2	0.4	-0.5	0.6	-0.4	0.4	0.3	-0.7	0.0
Risk taking	3.1	4.5	9.5	2.4	-1.8	0.0	2.9	1.4	1.6	3.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	4.3	-0.1	-0.1	-2.1	0.5	-0.2	0.4	-0.1
Fractured/broken bones in last 5 years	0.4	0.5	1.5	-0.3	1.2	-0.9	-0.7	-0.1	-0.5	-0.5
Age started oral contraceptive pill	1.2	1.5	3.8	1.1	1.2	1.6	1.0	-0.1	-0.3	1.9
Diastolic blood pressure, automated reading	4.3	13.4	22.1	-4.7	1.6	2.5	-4.5	-4.7	-0.6	-4.6
Ever depressed for a whole week	0.5	0.6	3.5	0.4	0.0	-1.9	0.5	0.4	-0.4	0.2
Unable to work because of sickness or disability	0.7	0.9	2.3	-0.5	0.7	1.3	-1.0	-0.2	0.8	-1.5
Commuting to job workplace: Cycle	0.7	0.9	2.4	-0.7	0.7	-0.1	-1.5	-0.8	-0.8	-1.2
Myopia	0.3	0.5	1.3	-0.4	-0.5	-0.3	0.6	-1.1	-1.1	0.4
Vascular/heart problems diagnosed by doctor	1.9	5.2	9.4	2.0	-1.8	-3.1	2.5	2.9	0.4	2.2
Cholesterol lowering medication	1.0	1.5	3.3	-1.3	-0.1	0.2	-1.8	-0.0	1.8	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	3.3	1.1	-0.7	0.1	0.9	0.3	0.1	1.8
Pain experienced in last month	1.2	2.0	6.2	1.1	-0.7	-0.6	2.0	1.0	-0.9	2.5
Supplements: Calcium	0.8	0.8	3.7	0.4	1.9	0.7	0.6	0.3	-0.9	0.6
Basal cell carcinoma (self-reported)	1.3	1.5	2.4	-1.6	1.5	0.4	-0.9	-1.3	-0.8	-1.5
Heart attack/myocardial infarction (self-reported)	0.7	0.9	4.4	0.6	0.7	0.9	0.5	0.3	2.1	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.7	0.2	0.2	-0.5	0.8	0.2	0.4	0.2
Heart disease (siblings)	0.8	1.0	4.0	-0.9	2.0	-0.4	-1.1	-0.4	-0.4	-0.7
Alcohol drinker status: Previous	0.2	0.3	1.4	-0.4	0.3	-0.4	-0.2	-0.2	-1.2	0.2
Pack years of smoking	0.9	1.3	4.5	0.2	-0.9	-0.2	0.3	2.1	1.9	0.1
Impedance of whole body	0.5	2.7	4.8	-1.7	2.2	0.9	-1.7	-1.8	-1.5	-1.5
Leg fat mass (left)	1.0	3.9	13.1	2.5	-3.6	0.2	1.7	1.7	0.9	1.2
Arm predicted mass (left)	1.1	5.7	15.9	2.4	-4.0	-0.2	2.4	2.8	1.0	1.7