Best TWAS P=4.28e-31 · Best GWAS P=9.06e-38 conditioned to 0.00341
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Frontal Cortex BA9 | EFEMP1 | 0.19 | 0.10 | lasso | 8 | 0.08 | 3.7e-03 | -11.3 | -11.6 | 4.3e-31 | 0.78 | 0.04 | 0.70 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | EFEMP1 | 0.11 | 0.00 | enet | 22 | 0.05 | 1.1e-04 | -0.3 | -6.1 | 1.0e-09 | 0.39 | 0.16 | 0.57 | TRUE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | EFEMP1 | 0.29 | 0.14 | enet | 37 | 0.19 | 2.2e-24 | -8.3 | -7.7 | 1.1e-14 | 0.64 | 1.00 | 0.00 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EFEMP1 | 0.02 | 0.01 | blup | 79 | 0.02 | 3.9e-05 | -12.8 | 8.3 | 9.0e-17 | -0.73 | 0.00 | 1.00 | FALSE |