[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) : ← →

chr2:134,928,375-137,435,625

Best TWAS P=1.07e-10 · Best GWAS P=4.29e-10 conditioned to 0.00036

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	YFS	Blood	DARS	0.17	0.19	enet	36	0.19	8.2e-60	5.6	6.5	1.1e-10	0.48	0.16	0.84	TRUE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	DARS	0.04	0.02	blup	40	0.01	2.1e-02	5.5	6.2	6.9e-10	0.44	0.02	0.93	FALSE
21	The Cancer Genome Atlas	Soft Tissue Sarcoma	DARS	0.04	0.04	blup	40	0.04	1.6e-03	5.8	6.0	2.2e-09	0.45	0.02	0.93	FALSE
8	GTEx	Thyroid	DARS	0.20	0.13	lasso	3	0.15	1.3e-11	5.5	5.8	5.8e-09	0.42	0.14	0.86	FALSE
6	GTEx	Skin Not Sun Exposed Suprapubic	DARS	0.15	0.11	enet	4	0.10	3.0e-06	5.5	5.8	6.1e-09	0.41	0.07	0.92	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	LCT	0.02	0.02	enet	3	0.03	7.6e-07	5.2	-5.8	6.3e-09	-0.47	0.02	0.98	FALSE
19	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DARS	0.08	0.10	lasso	4	0.09	8.8e-05	5.8	5.8	7.3e-09	0.41	0.02	0.93	FALSE
18	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DARS	0.02	0.02	lasso	2	0.02	3.9e-03	5.7	5.8	8.6e-09	0.39	0.01	0.93	FALSE
5	GTEx	Nerve Tibial	DARS	0.13	0.06	lasso	5	0.05	3.2e-04	5.8	5.7	1.0e-08	0.41	0.09	0.87	FALSE
22	The Cancer Genome Atlas	Thyroid Carcinoma	DARS	0.22	0.15	enet	13	0.19	4.1e-18	5.4	5.7	1.2e-08	0.33	0.03	0.97	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DARS	0.10	0.08	enet	14	0.11	5.5e-12	5.8	5.7	1.5e-08	0.39	0.02	0.98	FALSE
2	GTEx	Esophagus Mucosa	DARS	0.12	0.05	lasso	4	0.04	9.0e-04	5.5	5.7	1.6e-08	0.42	0.11	0.77	FALSE
9	NTR	Blood	MCM6	0.02	0.02	lasso	2	0.03	1.2e-08	4.7	5.7	1.6e-08	0.47	0.18	0.82	FALSE
3	GTEx	Esophagus Muscularis	DARS	0.12	0.11	lasso	3	0.09	3.5e-06	5.5	5.6	1.7e-08	0.40	0.09	0.90	FALSE
4	GTEx	Lung	DARS	0.07	0.05	lasso	4	0.05	5.8e-05	5.5	5.6	1.9e-08	0.40	0.10	0.89	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LCT	0.04	0.02	blup	36	0.02	1.9e-03	4.7	-5.5	4.7e-08	-0.50	0.06	0.79	FALSE
7	GTEx	Skin Sun Exposed Lower leg	DARS	0.10	0.12	lasso	1	0.11	1.7e-09	5.5	5.5	5.0e-08	0.39	0.21	0.79	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	CCNT2	0.06	0.03	enet	27	0.05	1.6e-06	5.1	5.4	5.6e-08	0.41	0.02	0.98	FALSE
13	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DARS	0.04	0.05	lasso	2	0.05	3.5e-06	5.2	5.4	7.3e-08	0.39	0.02	0.98	FALSE
17	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DARS	0.09	0.07	blup	40	0.06	1.6e-04	5.8	5.3	1.0e-07	0.27	0.02	0.97	FALSE
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ACMSD	0.04	0.01	blup	46	0.02	2.2e-03	4.9	5.3	1.3e-07	0.37	0.02	0.83	FALSE
1	CommonMind	Brain Pre-frontal Cortex	LOC100129961	0.17	0.14	enet	9	0.14	2.6e-17	-4.5	-5.2	2.1e-07	-0.36	0.16	0.82	FALSE