TWAS
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Models
Genes
Traits
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Traits
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Forced expiratory volume in 1-second (FEV1)
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chr2:100,029,106-101,629,737
Best TWAS P=2.3e-10 · Best GWAS P=5.1e-11 conditioned to 0.0432
100M
100.2M
100.4M
100.6M
100.8M
101M
101.2M
101.4M
101.6M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Lung
LONRF2
0.08
0.00
lasso
6
0.0
2.4e-01
-6.5
-6.3
2.3e-10
0.89
0.02
0.98
TRUE
2
ROSMAP
Brain Pre-frontal Cortex
AC092667.2
0.16
0.03
blup
439
0.1
2.2e-12
-4.8
5.5
2.8e-08
-0.43
0.78
0.22
FALSE