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Traits
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Forced expiratory volume in 1-second (FEV1)
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chr3:56,629,678-58,613,378
Best TWAS P=1.62e-12 · Best GWAS P=6.1e-14 conditioned to 1
57M
57.5M
58M
58.5M
0
5
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Esophagus Muscularis
SLMAP
0.06
0.05
lasso
4
0.05
0.00052
7.5
7.1
1.6e-12
0.98
0.02
0.97
TRUE
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
SLMAP
0.01
0.01
blup
86
0.01
0.00911
7.3
6.7
2.7e-11
0.98
0.02
0.84
FALSE
2
ROSMAP
Brain Pre-frontal Cortex
DNAH12
0.04
0.00
blup
448
0.02
0.00103
3.6
5.8
5.3e-09
0.41
0.18
0.09
FALSE