TWAS hub - SLMAP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.0610	0.0270	0.0023	0.051	NA	0.033	NA	0.050	0.00045	NA	0.0043	NA	0.00052
2	TCGA	Breast Invasive Carcinoma	0.0098	0.0062	0.0063	0.009	0.007	0.003	NA	0.007	0.00530	0.0091	0.0580	NA	0.00950

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Lung FEV1/FVC ratio	20.0	101.6	108.2	10.4	9.8
Eye problems/disorders: None of the above	14.4	16.7	16.9	4.1	4.1
Forced expiratory volume in 1-second (FEV1)	14.0	47.1	49.8	7.1	6.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	13.3	28.2	30.8	5.0	5.5
Forced expiratory volume in 1-second (FEV1), Best measure	9.4	30.1	31.9	5.7	5.3
Pain experienced in last month	9.1	15.1	16.8	4.1	3.7
Neuroticism (2016)	7.7	11.1	11.2	-3.3	-3.3
Frequency of tenseness / restlessness in last 2 weeks	7.7	12.0	12.3	-3.5	-3.4
Lung FVC	7.6	38.4	39.3	6.3	6.1
Health satisfaction	7.2	9.3	9.6	-3.1	-3.0
Eye problems/disorders: Cataract	7.2	8.3	9.6	-3.1	-2.6
Back pain experienced in last month	7.1	10.3	11.0	-3.3	-3.1
Osteoarthritis (self-reported)	7.0	9.1	9.2	-3.0	-3.0
Diastolic blood pressure, automated reading	6.9	21.4	22.0	4.6	4.7
Mood swings	5.7	10.3	10.7	-3.3	-3.1
Depression (Nagel 2018)	5.6	8.4	8.8	-3.0	-2.8
Peak expiratory flow (PEF)	5.5	12.8	13.7	3.5	3.7
Medication: Seretide 50 evohaler	5.4	6.2	6.7	-2.4	-2.6
Smoking Status	5.1	12.2	14.5	-3.8	-3.1
Forced vital capacity (FVC)	5.1	19.5	20.4	4.5	4.3
Major Depression (MDD)	5.0	6.1	6.4	-2.4	-2.5
Medication: Ramipril	5.0	6.5	7.3	2.7	2.4
Illness, injury, bereavement, stress in last 2 years	5.0	6.1	6.6	2.6	2.4
Qualifications: O levels/GCSEs or equivalent	4.9	7.8	9.1	3.0	2.6
Depressed Affect (Nagel 2018)	4.6	9.7	11.0	-3.3	-2.9
Miserableness	4.6	7.9	8.8	-3.0	-2.6
Number of treatments/medications taken	4.5	8.1	9.0	-3.0	-2.7
Heart attack	4.5	5.8	6.6	2.2	2.6
Commuting to job workplace: Walk	4.3	4.7	5.2	2.0	2.3
Coronary Artery Disease (CAD)	4.2	5.0	5.4	2.1	2.3
Taking other prescription medications	4.2	6.4	6.7	-2.5	-2.6
Pulse wave reflection index	4.2	5.1	5.6	2.4	2.2
Overall health rating	4.2	9.1	10.4	-3.2	-2.8
Illnesses of father: Heart disease	4.2	5.8	6.3	2.5	2.3
Frequency of depressed mood in last 2 weeks	4.0	5.6	5.9	-2.4	-2.3
Commuting to job workplace: Public transport	4.0	4.8	6.1	2.5	1.8
Fed-up feelings	3.9	7.0	7.9	-2.5	-2.8
Heel bone mineral density (BMD) T-score, automated (left)	3.8	8.6	8.6	2.9	2.9
Shortness of breath walking on level ground	3.8	4.5	4.9	-2.2	-2.0
Heart attack/myocardial infarction (self-reported)	3.6	4.7	5.3	2.0	2.3
Heel bone mineral density (BMD) T-score, automated (right)	3.5	7.9	8.1	2.8	2.8
Neuroticism (Nagel 2018)	3.4	8.1	9.6	-3.1	-2.6
Medication for pain relief, constipation, heartburn	3.4	5.8	6.5	2.6	2.3
Stomach or abdominal pain in last month	3.3	4.1	5.0	-1.8	-2.2
Number of live births	3.3	4.7	6.0	-1.8	-2.5
Forced vital capacity (FVC), Best measure	3.3	12.1	12.6	3.5	3.4
Suffer from ‘nerves’	3.3	5.2	5.4	-2.2	-2.3
Alcohol usually taken with meals	3.2	5.2	5.3	2.3	2.3
Respiratory disease	3.1	6.8	8.5	-2.3	-2.9
Long-standing illness, disability or infirmity	3.1	4.8	5.9	-2.4	-1.9
Alzheimer’s Disease (including proxy)	2.9	4.2	4.9	-2.2	-1.9
Wheeze or whistling in the chest in last year	2.8	5.0	5.2	-2.3	-2.2
Qualifications: nursing, teaching	2.8	4.3	4.5	2.0	2.1
Supplements: Calcium	2.8	3.1	3.2	-1.7	-1.8
Exposure to tobacco smoke outside home	2.7	3.6	4.2	-2.1	-1.7
Knee pain experienced in last month	2.7	4.2	5.1	-2.3	-1.8
Schizophrenia vs Biploar Disorder	2.6	3.4	3.8	-1.7	-1.9
Waist Hip Ratio (WHR)	2.6	11.6	11.8	3.4	3.4
Birth weight of first child	2.6	4.7	5.7	2.4	1.9
Neck or shoulder pain in last month	2.6	3.6	4.1	-2.0	-1.8
Medication: Allopurinol	2.6	3.4	4.0	-1.7	-2.0
Mineral and other dietary supplements	2.6	3.4	3.6	1.8	1.9
Trunk fat percentage	2.5	10.2	11.8	-2.9	-3.4
Supplements: Glucosamine	2.5	3.3	3.3	-1.8	-1.8
Neuroticism score	2.5	5.3	5.8	-2.4	-2.2
Arm fat percentage (right)	2.5	9.9	11.3	-2.9	-3.4
Arm fat percentage (left)	2.5	10.1	11.6	-2.9	-3.4
Ever taken oral contraceptive pill	2.5	2.8	3.0	-1.6	-1.7
Heel T-Score	2.4	19.2	20.3	4.2	4.5
Financial difficulties in last 2 years	2.4	3.3	3.6	-1.9	-1.7
Number of full brothers	2.4	3.0	4.5	-1.2	-2.1
Medication: Omeprazole	2.4	2.8	2.9	-1.7	-1.7
Past tobacco smoking	2.3	4.2	4.3	2.0	2.1
Hip circumference	2.3	9.9	12.0	-2.8	-3.5
Medication: Paracetamol	2.3	3.8	4.1	-2.0	-1.9
Headache pain in last month	2.3	3.9	4.0	-2.0	-2.0
Smoking status: Previous	2.3	3.4	3.6	-1.9	-1.8
Loneliness, isolation	2.3	3.2	3.5	-1.9	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.4	3.7	-1.9	-1.8
Body fat percentage	2.2	8.6	10.1	-2.7	-3.2
Alzheimer’s Disease (in mother)	2.1	2.5	3.2	-1.8	-1.4
HDL Cholesterol	2.1	3.6	4.0	-2.0	-1.8
Diabetes diagnosed by doctor	2.1	3.4	3.5	-1.8	-1.9
Medication: Paracetamol	2.1	3.2	3.9	-2.0	-1.6
Primary Biliary Cirrhosis	2.0	2.9	3.7	1.4	1.9
Ever used hormone-replacement therapy (HRT)	2.0	2.6	3.5	-1.9	-1.3
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	2.5	-1.4	-1.6
Trunk fat mass	2.0	8.6	10.4	-2.6	-3.2
Emphysema/chronic bronchitis	2.0	2.3	2.6	-1.6	-1.4
Whole body fat mass	2.0	8.4	10.1	-2.6	-3.2
Smoking status: Current	2.0	3.2	4.0	-2.0	-1.6
Falls in the last year	1.9	2.5	2.7	-1.6	-1.5
Medication: Cholesterol lowering	1.9	3.0	3.2	1.6	1.8
Worry too long after embarrassment	1.9	3.3	3.7	-1.9	-1.7
Medication: Omeprazole (e.g. Zanprol)	1.9	2.4	2.6	-1.5	-1.6
Diabetes (father)	1.8	2.3	3.2	-1.8	-1.1
Medication: Atenolol	1.8	2.3	2.7	-1.6	-1.4
Diabetes (self-reported)	1.8	2.8	3.1	-1.6	-1.8
Ever depressed for a whole week	1.8	2.2	2.5	1.4	1.6
Depression (self-reported)	1.7	2.0	2.3	-1.3	-1.5
Medication: Lansoprazole	1.7	2.0	2.3	-1.3	-1.5
Myopia	1.7	2.5	2.6	1.5	1.6
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	1.8	-1.3	-1.3
Chronic bronchitis/emphysema (father)	1.6	1.9	2.5	-1.6	-1.1
Arm fat mass (right)	1.6	6.7	8.3	-2.2	-2.9
Arm fat mass (left)	1.6	6.6	8.2	-2.2	-2.9
Prostate Cancer	1.5	2.1	2.7	1.2	1.6
Happiness	1.5	1.8	2.5	-1.6	-1.1
Mouth/teeth dental problems: Dentures	1.5	2.6	2.6	1.6	1.6
Pulse wave Arterial Stiffness index	1.5	1.8	2.4	1.5	1.1
Age started oral contraceptive pill	1.5	1.9	2.0	-1.3	-1.4
Crohns Disease (2012)	1.4	2.3	3.5	1.9	1.0
Illnesses of father: None of the above (group 1)	1.4	1.8	1.9	-1.3	-1.4
Average weekly champagne plus white wine intake	1.4	1.9	2.4	1.5	1.2
Reaction Time	1.3	2.4	3.5	1.9	1.1
Blood White Count	1.3	9.4	10.9	-2.8	-3.3
Systolic Blood Pressure	1.3	6.5	7.7	2.3	2.8
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	2.1	-1.5	-1.1
Diabetes (mother)	1.3	1.7	2.5	1.6	0.9
Hand grip strength (right)	1.3	3.6	4.3	2.1	1.7
Mouth/teeth dental problems	1.3	2.0	2.5	-1.2	-1.6
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	3.0	-1.7	-1.1
Medication: Ventolin 100micrograms inhaler	1.3	1.7	2.4	-1.0	-1.5
Pulse wave peak to peak time	1.3	1.6	2.1	-1.4	-1.0
Medication: Lisinopril	1.3	1.6	2.4	-1.6	-0.9
Blood Platelet Count	1.2	13.8	18.4	-4.3	-3.0
Hand grip strength (left)	1.2	3.3	4.8	2.2	1.3
Current tobacco smoking	1.2	2.0	2.8	-1.7	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	1.6	-1.2	-1.3
Qualifications: None of the above	1.2	2.7	3.5	-1.9	-1.3
Asthma	1.2	2.4	3.3	-1.3	-1.8
Birth weight	1.2	2.6	3.3	1.8	1.3
Leg pain on walking	1.2	1.5	1.6	-1.2	-1.3
Medication: Gliclazide	1.2	1.3	1.5	-1.2	-1.1
Ever had prostate specific antigen (PSA) test	1.2	1.3	1.8	-1.4	-0.9
Leg fat mass (left)	1.2	4.9	6.2	-1.9	-2.5
Serious illness, injury or assault to yourself	1.1	1.4	1.5	1.1	1.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	2.3	-1.2	-1.5
Leg fat mass (right)	1.1	4.3	5.4	-1.8	-2.3
Average weekly beer plus cider intake	1.1	1.6	1.8	-1.3	-1.2
LDL Cholesterol	1.0	1.6	1.6	1.3	1.2
Type 2 Diabetes (T2D) (2018)	1.0	2.0	2.2	-1.3	-1.5
Neuroticism	1.0	2.3	2.8	-1.7	-1.3
Weight	1.0	4.7	6.2	-1.8	-2.5
Noisy workplace	1.0	1.3	1.5	-1.2	-1.0
Mean time to correctly identify matches	1.0	1.9	3.0	1.7	0.9
Alcohol drinker status: Never	1.0	1.2	1.4	1.0	1.2
Ever smoked	1.0	1.7	2.0	-1.2	-1.4
Leg fat percentage (left)	1.0	3.8	5.0	-1.6	-2.2
Pain all over the body in last month	0.9	0.9	1.6	-1.2	-0.6
Worrier / anxious feelings	0.9	1.7	2.1	-1.4	-1.2
Qualifications: A levels/AS levels or equivalent	0.9	2.0	2.1	1.4	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	1.5	-1.2	-0.9
Fasting Glucose	0.8	0.9	1.1	1.1	0.9
Maternal smoking around birth	0.8	1.1	1.5	-0.8	-1.2
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.0	-0.9	-1.0
Body mass index (BMI)	0.8	3.6	4.5	-1.6	-2.1
Hearing difficulty/problems with background noise	0.8	1.3	2.0	-1.4	-0.8
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.2	0.9	1.1
Pulse rate	0.8	1.3	1.5	-1.1	-1.2
Leg fat percentage (right)	0.8	2.8	3.5	-1.4	-1.9
Age at first live birth	0.8	1.3	1.5	-1.2	-1.1
Medication: Blood pressure	0.8	1.3	1.8	0.9	1.3
Migraine (self-reported)	0.8	1.0	1.6	-0.6	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.2	-1.1	-0.9
Breast cancer (self-reported)	0.8	0.9	1.1	-1.1	-0.9
Asthma (self-reported)	0.8	1.5	2.1	-0.9	-1.5
Financial situation satisfaction	0.8	1.0	1.1	-1.0	-1.0
Medication: Atorvastatin	0.8	1.0	1.0	1.0	1.0
Bipolar Disorder (2018)	0.7	1.1	1.3	1.1	1.0
Breast Cancer	0.7	1.6	1.8	1.2	1.4
Bipolar Disorder (2011)	0.7	0.6	0.7	0.9	0.7
Mean Putamen Volume	0.7	0.8	1.4	1.2	0.4
HbA1C	0.7	0.8	0.9	1.0	0.8
Rheumatoid Arthritis	0.7	1.0	1.5	-1.2	-0.6
Nervous feelings	0.7	1.3	1.6	-1.3	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.4	-1.2	-0.5
Exposure to tobacco smoke at home	0.7	0.7	1.1	-0.6	-1.0
Hair/balding pattern: Pattern 4	0.7	1.6	2.0	1.4	1.1
Glaucoma (self-reported)	0.7	0.8	1.0	-0.8	-1.0
Medication: Ibuprofen	0.7	0.8	1.0	-1.0	-0.8
Heart disease (mother)	0.7	0.8	0.8	0.9	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.2	-0.7	-1.1
Guilty feelings	0.7	1.1	1.4	-1.2	-0.9
Intelligence (Savage-Jansen 2018)	0.6	2.0	2.4	-1.6	-1.2
Ulcerative Colitis	0.6	0.8	0.9	-0.9	-0.9
BMI	0.6	3.2	3.8	-1.6	-1.9
Leg fat-free mass (left)	0.6	3.1	4.1	-1.5	-2.0
Age when periods started (menarche)	0.6	1.3	2.0	-0.8	-1.4
Leg predicted mass (left)	0.6	3.1	4.1	-1.4	-2.0
Number of incorrect matches in round	0.6	1.0	1.0	1.0	1.0
Time employed in main current job	0.6	0.6	1.0	-1.0	-0.5
Impedance of arm (left)	0.6	2.9	3.4	-1.8	-1.6
Comparative body size at age 10	0.6	1.7	2.2	-1.5	-1.1
Qualifications: College or University degree	0.6	2.0	3.0	1.0	1.7
Leg predicted mass (right)	0.6	3.1	4.2	-1.4	-2.1
Irritability	0.6	1.0	1.4	-1.2	-0.9
Risk taking	0.6	0.8	0.9	-0.9	-0.8
Schizophrenia (2018)	0.5	1.0	1.2	-1.1	-0.9
Worry (Nagel 2018)	0.5	1.1	1.4	-1.2	-0.9
Schizophrenia (2014)	0.5	1.0	1.3	-1.1	-0.9
Chronotype (morning person)	0.5	1.1	1.3	1.1	1.0
Ever had hysterectomy (womb removed)	0.5	0.6	0.9	0.4	1.0
Had menopause	0.5	0.6	0.9	0.5	0.9
Impedance of arm (right)	0.5	2.4	3.0	-1.7	-1.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	0.8	0.7	0.9
Leg fat-free mass (right)	0.5	2.8	3.9	-1.3	-2.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.0	-0.5	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	1.3	-1.1	-0.6
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.0	-1.0	-0.5
High cholesterol (Self-reported)	0.5	1.0	1.0	1.0	0.9
Pack years of smoking	0.5	0.7	0.8	-0.8	-0.9
Medication for hormone replacement therapy	0.4	0.4	0.7	0.4	0.8
Vitamin and mineral supplements	0.4	0.5	0.9	0.4	1.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.6	0.8	0.7
High blood pressure (mother)	0.4	0.5	0.9	0.4	0.9
Medication: Simvastatin	0.4	0.5	0.7	0.6	0.8
Hair/balding pattern: Pattern 3	0.4	0.6	0.9	-1.0	-0.6
Prospective memory result	0.4	0.5	0.7	0.8	0.6
Loud music exposure frequency	0.4	0.5	0.6	0.8	0.6
Gout (self-reported)	0.4	0.6	0.8	-0.5	-0.9
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.8	-0.9	-0.3
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.6	-0.7	-0.8
Height	0.3	6.6	8.0	-2.3	-2.8
Impedance of leg (right)	0.3	1.6	1.9	1.1	1.4
Waist circumference	0.3	1.1	1.6	-0.7	-1.3
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	0.9	-0.0
Medication: Amlodipine	0.3	0.4	0.7	0.2	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.5	-0.6	-0.7
Number of children fathered	0.3	0.3	0.5	-0.7	-0.4
Pulse rate, automated reading	0.3	1.1	1.5	-0.9	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.5	-0.4	-0.7
Mother’s age at death	0.3	0.4	0.5	0.6	0.7
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.5	0.7	0.3
Eye problems/disorders: Glaucoma	0.3	0.3	0.3	-0.6	-0.6
Basal metabolic rate	0.3	1.4	2.3	-0.8	-1.5
Basal cell carcinoma (self-reported)	0.3	0.4	0.4	-0.6	-0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.2	-0.5	-0.4
Crohns Disease (2017)	0.2	0.5	0.9	0.9	0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.5	-0.7	-0.7
Blood Red Count	0.2	2.2	3.5	1.9	0.9
Allergy or Eczema	0.2	0.5	0.6	-0.8	-0.7
Cardiovascular Disease	0.2	0.8	1.0	0.7	1.0
Sensitivity / hurt feelings	0.2	0.3	0.4	-0.7	-0.4
Systolic blood pressure, automated reading	0.2	0.6	0.9	0.4	1.0
Supplements: Zinc	0.2	0.2	0.2	-0.4	-0.5
Medication: Metformin	0.2	0.3	0.3	-0.6	-0.5
Average weekly fortified wine intake	0.2	0.2	0.5	0.1	0.7
Qualifications: CSEs or equivalent	0.2	0.2	0.4	-0.3	-0.6
Multivitamins +/- minerals	0.2	0.2	0.3	0.3	-0.6
Medication: Levothyroxine sodium	0.2	0.3	0.3	-0.6	-0.4
Impedance of leg (left)	0.2	0.9	0.9	1.0	1.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.4	0.5	0.6
Allergy	0.2	0.5	0.7	0.6	0.8
Illnesses of mother	0.2	0.3	0.5	-0.4	-0.7
Length of working week for main job	0.2	0.2	0.3	0.2	0.6
Breastfed as a baby	0.2	0.2	0.4	-0.2	-0.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.2	-0.4	0.5
Blood clot in the leg (DVT)	0.2	0.3	0.3	0.6	0.5
Angina (self-reported)	0.2	0.3	0.4	-0.5	-0.6
Chest pain or discomfort	0.2	0.3	0.3	-0.5	-0.5
Family relationship satisfaction	0.2	0.3	0.4	-0.5	-0.6
Medication: Bendroflumethiazide	0.2	0.3	0.5	-0.0	0.7
Illnesses of father: High blood pressure	0.2	0.3	0.3	0.5	0.5
Ovarian Cancer	0.1	0.1	0.2	0.1	0.5
Triglycerides	0.1	0.1	0.2	0.4	0.2
Hair Pigment	0.1	1.5	1.7	1.3	1.1
Average weekly spirits intake	0.1	0.1	0.1	-0.3	0.2
Angina	0.1	0.1	0.2	-0.3	-0.4
Severe depression (siblings)	0.1	0.1	0.1	-0.3	0.0
Pack years adult smoking proportion	0.1	0.2	0.2	-0.4	-0.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	-0.5	-0.4
Had other major operations	0.1	0.2	0.3	0.6	0.2
Fluid intelligence score	0.1	0.3	0.4	-0.3	-0.7
Lung cancer (father)	0.1	0.1	0.2	-0.4	-0.2
Standing height	0.1	1.0	1.5	-0.7	-1.2
Tense / ‘highly strung’	0.1	0.2	0.3	-0.5	-0.3
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.2	-0.3	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	0.2	0.4
Comparative height size at age 10	0.1	0.5	0.7	0.8	0.5
Number of full sisters	0.1	0.1	0.2	0.1	0.4
Medication: Aspirin	0.1	0.1	0.2	-0.5	0.1
Hypertension (Self-reported)	0.1	0.2	0.4	-0.6	-0.2
Illnesses of siblings: Diabetes	0.1	0.1	0.1	0.1	0.3
Whole body fat-free mass	0.1	0.7	1.3	-0.4	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.4	0.2
Friendships satisfaction	0.1	0.1	0.1	-0.4	-0.3
Medication for cholesterol	0.1	0.1	0.2	0.4	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	0.1	-0.5
Whole body water mass	0.1	0.6	1.0	-0.3	-1.0
Wears glasses or contact lenses	0.1	0.1	0.2	0.5	0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.1	-0.4	-0.3
Arm fat-free mass (left)	0.1	0.4	0.7	-0.1	-0.8
Number of operations (self-reported)	0.1	0.2	0.3	0.2	0.5
Fractured/broken bones in last 5 years	0.1	0.1	0.1	-0.3	-0.2
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.5	-0.4	-0.7
Cholesterol lowering medication	0.1	0.1	0.2	0.2	0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.2	0.5	0.3
Heart disease (siblings)	0.1	0.1	0.2	0.2	-0.5
Alcohol drinker status: Previous	0.1	0.1	0.1	0.3	0.1
Impedance of whole body	0.1	0.3	0.4	-0.6	-0.4
Bipolar Disorder or Schizophrenia	0.0	0.0	0.0	-0.1	-0.1
Irritable Bowel Disease (IBD)	0.0	0.1	0.2	0.5	-0.1
Ulcerative Colitis (UC)	0.0	0.0	0.0	0.1	-0.1
Age at First Birth	0.0	0.1	0.1	-0.3	-0.1
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	-0.2	-0.0
Lupus	0.0	0.0	0.0	0.2	0.2
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	0.2	0.2
Blood Eosinophil Count	0.0	0.0	0.1	0.1	0.3
Hypothyroidism (self reported)	0.0	0.1	0.2	0.0	0.4
Tanning	0.0	0.1	0.1	-0.3	-0.3
Hearing difficulty/problems: Yes	0.0	0.0	0.0	0.1	-0.1
Relative age of first facial hair	0.0	0.1	0.1	-0.3	0.1
Medication: Co-codamol	0.0	0.0	0.0	-0.1	-0.0
Townsend deprivation index at recruitment	0.0	0.0	0.0	0.1	-0.2
Relative age voice broke	0.0	0.0	0.0	-0.1	-0.2
High blood pressure	0.0	0.1	0.1	-0.3	0.1
Sitting height	0.0	0.3	0.3	-0.5	-0.5
Illnesses of siblings	0.0	0.0	0.1	0.1	0.3
Trunk fat-free mass	0.0	0.2	0.4	0.1	-0.6
Alcohol intake versus 10 years previously	0.0	0.1	0.1	-0.3	-0.3
Father’s age at death	0.0	0.0	0.1	-0.1	-0.3
Trunk predicted mass	0.0	0.2	0.5	0.1	-0.7
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	-0.0	0.2
High blood pressure (siblings)	0.0	0.0	0.0	0.1	0.1
Arm fat-free mass (right)	0.0	0.2	0.3	0.3	-0.5
Arm predicted mass (right)	0.0	0.2	0.2	0.4	-0.4
Alcohol intake frequency.	0.0	0.1	0.2	0.1	0.4
Had major operations	0.0	0.1	0.1	-0.1	0.3
Age at last live birth	0.0	0.1	0.1	-0.3	-0.2
Supplements: Vitamin C	0.0	0.0	0.0	0.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	-0.3	-0.3
Average weekly red wine intake	0.0	0.0	0.0	0.0	-0.0
Ever had bowel cancer screening	0.0	0.0	0.0	0.2	-0.1
Osteoporosis (self-reported)	0.0	0.0	0.0	-0.2	-0.1
Medication: Aspirin	0.0	0.1	0.1	-0.2	0.3
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	0.3	-0.2
Hearing aid user	0.0	0.0	0.0	0.0	-0.2
Medication: Blood pressure	0.0	0.0	0.0	0.1	0.1
Unable to work because of sickness or disability	0.0	0.0	0.0	0.0	-0.1
Commuting to job workplace: Cycle	0.0	0.0	0.0	-0.2	0.2
Arm predicted mass (left)	0.0	0.2	0.4	0.1	-0.6

Hub : Genes

SLMAP

Models

Trait associations