Best TWAS P=3.07e-12 · Best GWAS P=3.68e-12 conditioned to 0.119
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | NOA1 | 0.17 | 0.06 | lasso | 4 | 0.06 | 3.5e-04 | 6.5 | -7.0 | 3.1e-12 | 0.90 | 0.01 | 0.98 | TRUE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | REST | 0.04 | 0.01 | lasso | 5 | 0.02 | 7.8e-04 | -5.2 | -6.9 | 7.1e-12 | 0.77 | 0.13 | 0.39 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C4orf14 | 0.03 | 0.04 | lasso | 3 | 0.04 | 1.9e-05 | -6.9 | -6.8 | 7.8e-12 | 0.99 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Muscle Skeletal | REST | 0.05 | 0.01 | enet | 9 | 0.02 | 3.9e-03 | -5.0 | -6.7 | 2.7e-11 | 0.85 | 0.02 | 0.97 | FALSE |
| 2 | GTEx | Colon Transverse | REST | 0.26 | 0.04 | lasso | 9 | 0.10 | 1.9e-05 | -3.8 | -6.2 | 6.0e-10 | 0.64 | 0.15 | 0.65 | FALSE |
| 5 | METSIM | Adipose | RP11-738E22.3 | 0.07 | 0.04 | lasso | 6 | 0.05 | 7.7e-08 | -5.2 | 6.1 | 1.4e-09 | -0.73 | 0.93 | 0.07 | FALSE |
| 4 | GTEx | Testis | REST | 0.15 | 0.08 | enet | 12 | 0.04 | 7.4e-03 | -4.8 | -5.3 | 9.3e-08 | 0.79 | 0.02 | 0.96 | FALSE |
| 8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C4orf14 | 0.13 | 0.11 | lasso | 2 | 0.10 | 6.2e-05 | -5.4 | -5.2 | 1.8e-07 | 0.81 | 0.03 | 0.74 | FALSE |