Best TWAS P=9.83e-10 · Best GWAS P=5.71e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DNALI1 | 0.12 | 0.07 | lasso | 4 | 0.14 | 1.8e-16 | 2.9 | 5.6 | 2.7e-08 | -0.75 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | DNALI1 | 0.24 | 0.07 | lasso | 10 | 0.07 | 6.0e-06 | -5.6 | 5.9 | 3.3e-09 | -0.98 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Thyroid | MEAF6 | 0.11 | 0.02 | lasso | 8 | 0.01 | 3.8e-02 | -5.6 | 5.5 | 4.7e-08 | -0.93 | 0.01 | 0.98 | FALSE |
| 4 | METSIM | Adipose | MEAF6 | 0.10 | 0.07 | bslmm | 452 | 0.06 | 6.0e-10 | -5.8 | 5.2 | 2.0e-07 | -0.97 | 0.00 | 1.00 | FALSE |
| 5 | YFS | Blood | SNIP1 | 0.17 | 0.12 | bslmm | 438 | 0.17 | 1.6e-54 | -5.8 | 5.5 | 3.2e-08 | -0.83 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DNALI1 | 0.06 | 0.05 | enet | 5 | 0.05 | 1.2e-10 | -5.8 | 5.5 | 3.2e-08 | -0.99 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Glioblastoma Multiforme | DNALI1 | 0.42 | 0.19 | lasso | 3 | 0.18 | 3.7e-06 | -5.8 | 5.8 | 5.7e-09 | -1.00 | 0.00 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DNALI1 | 0.04 | 0.00 | blup | 41 | 0.01 | 7.8e-02 | -5.8 | 6.1 | 1.1e-09 | -0.92 | 0.00 | 0.94 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DNALI1 | 0.11 | 0.09 | lasso | 1 | 0.09 | 6.8e-10 | -5.8 | 5.8 | 5.7e-09 | -1.00 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MEAF6 | 0.11 | 0.07 | lasso | 1 | 0.05 | 8.2e-07 | -5.8 | 5.8 | 5.7e-09 | -1.00 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DNALI1 | 0.12 | 0.09 | lasso | 4 | 0.07 | 1.1e-04 | -5.8 | 5.8 | 6.8e-09 | -1.00 | 0.00 | 0.99 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DNALI1 | 0.26 | 0.25 | enet | 9 | 0.26 | 9.4e-29 | -5.8 | 6.0 | 1.6e-09 | -0.99 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Adenocarcinoma | DNALI1 | 0.06 | 0.03 | blup | 41 | 0.04 | 2.7e-05 | -5.3 | 6.0 | 2.4e-09 | -0.86 | 0.00 | 0.99 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DNALI1 | 0.07 | 0.05 | lasso | 4 | 0.04 | 1.7e-05 | -5.8 | 6.1 | 9.8e-10 | -0.98 | 0.00 | 0.99 | TRUE |
| 15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FHL3 | 0.08 | 0.08 | lasso | 2 | 0.08 | 1.4e-09 | -5.2 | 5.4 | 6.9e-08 | -0.10 | 0.00 | 1.00 | TRUE |
| 16 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | DNALI1 | 0.21 | 0.16 | blup | 41 | 0.16 | 4.1e-07 | -5.8 | 5.7 | 1.1e-08 | -0.95 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | DNALI1 | 0.27 | 0.12 | lasso | 5 | 0.11 | 3.9e-05 | -5.8 | 5.8 | 5.7e-09 | -1.00 | 0.00 | 0.98 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DNALI1 | 0.05 | 0.01 | blup | 41 | 0.02 | 1.5e-03 | -5.8 | 5.4 | 6.0e-08 | -0.76 | 0.00 | 0.82 | FALSE |
| 19 | The Cancer Genome Atlas | Soft Tissue Sarcoma | DNALI1 | 0.09 | 0.01 | blup | 41 | 0.02 | 2.5e-02 | -5.8 | 5.8 | 5.3e-09 | -0.84 | 0.00 | 0.79 | FALSE |
| 20 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | DNALI1 | 0.49 | 0.04 | lasso | 7 | 0.31 | 4.7e-09 | -5.3 | 5.5 | 3.4e-08 | -0.72 | 0.01 | 0.97 | FALSE |
| 21 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | DNALI1 | 0.17 | 0.10 | blup | 41 | 0.08 | 1.2e-03 | -5.8 | 5.5 | 3.2e-08 | -0.92 | 0.00 | 0.89 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | DNALI1 | 0.10 | 0.07 | lasso | 2 | 0.07 | 1.4e-07 | -5.8 | 5.8 | 6.4e-09 | -1.00 | 0.00 | 1.00 | FALSE |