Best TWAS P=4.39e-18 · Best GWAS P=8.55e-16 conditioned to 0.493
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | SCMH1 | 0.07 | 0.08 | blup | 97 | 0.07 | 2.5e-07 | 8.05 | -8.7 | 4.4e-18 | -0.89 | 0.00 | 1.00 | TRUE |
| 4 | GTEx | Nerve Tibial | SCMH1 | 0.16 | 0.03 | enet | 24 | 0.07 | 1.6e-05 | 7.80 | -7.7 | 1.3e-14 | -0.77 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SCMH1 | 0.03 | 0.03 | lasso | 2 | 0.02 | 6.2e-03 | 7.11 | -7.1 | 1.2e-12 | -0.63 | 0.12 | 0.33 | FALSE |
| 3 | GTEx | Lung | CTPS1 | 0.06 | 0.04 | lasso | 3 | 0.04 | 2.4e-04 | 5.65 | 5.8 | 5.4e-09 | 0.69 | 0.24 | 0.58 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | CTPS1 | 0.26 | 0.11 | lasso | 6 | 0.08 | 1.6e-03 | 5.81 | 5.4 | 6.7e-08 | 0.79 | 0.22 | 0.26 | FALSE |
| 1 | GTEx | Brain Cerebellum | FOXO6 | 0.35 | 0.33 | enet | 21 | 0.36 | 1.2e-11 | 3.59 | 5.2 | 1.5e-07 | 0.55 | 0.71 | 0.29 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SCMH1 | 0.04 | 0.01 | enet | 7 | 0.02 | 2.5e-03 | -0.18 | -5.2 | 2.5e-07 | -0.29 | 0.06 | 0.08 | FALSE |