[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) : ← →

chr1:25,475,418-27,595,862

Best TWAS P=6.28e-15 · Best GWAS P=1.61e-12 conditioned to 0.0173

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Esophagus Mucosa	DHDDS	0.11	0.06	lasso	4	0.04	6.6e-04	-6.8	-7.8	6.3e-15	0.60	0.01	0.99	TRUE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRIM63	0.29	0.33	enet	20	0.33	2.5e-38	6.3	7.0	2.3e-12	-0.07	0.01	0.99	TRUE
26	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RPS6KA1	0.11	0.05	lasso	6	0.07	8.0e-04	-6.4	7.3	2.8e-13	-0.73	0.01	0.85	FALSE
13	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM63	0.03	0.02	blup	33	0.02	4.6e-03	6.3	6.8	1.1e-11	-0.08	0.01	0.83	FALSE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	TRIM63	0.08	0.10	lasso	4	0.10	3.7e-06	6.3	6.6	4.2e-11	-0.08	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	TRIM63	0.18	0.26	enet	7	0.26	3.0e-25	6.3	6.5	7.6e-11	-0.07	0.02	0.98	FALSE
10	GTEx	Thyroid	CNKSR1	0.10	0.04	lasso	7	0.03	2.1e-03	6.0	-6.5	7.8e-11	0.15	0.40	0.52	FALSE
22	The Cancer Genome Atlas	Lung Adenocarcinoma	TRIM63	0.14	0.20	enet	7	0.21	9.4e-24	6.3	6.5	8.6e-11	-0.08	0.02	0.98	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIM63	0.15	0.16	lasso	2	0.16	2.3e-32	6.3	6.4	2.0e-10	-0.07	0.01	0.99	FALSE
3	GTEx	Esophagus Mucosa	PDIK1L	0.10	0.09	lasso	6	0.09	8.8e-07	6.3	-6.3	2.4e-10	0.10	0.23	0.77	FALSE
15	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TRIM63	0.14	0.15	lasso	1	0.14	2.2e-07	6.3	6.3	2.4e-10	-0.07	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRIM63	0.16	0.11	lasso	1	0.10	2.0e-11	6.3	6.3	2.9e-10	-0.08	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TRIM63	0.19	0.07	blup	33	0.14	1.3e-04	6.3	6.3	3.2e-10	-0.06	0.01	0.98	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC30A2	0.03	0.02	lasso	3	0.01	1.1e-02	5.3	-6.3	3.6e-10	0.08	0.01	0.93	FALSE
25	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRIM63	0.14	0.18	lasso	7	0.15	3.0e-10	6.3	6.3	4.0e-10	-0.07	0.01	0.99	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDIK1L	0.02	0.02	blup	37	0.02	2.8e-03	6.3	-6.2	5.7e-10	0.08	0.01	0.84	FALSE
28	The Cancer Genome Atlas	Rectum Adenocarcinoma	TRIM63	0.28	0.22	lasso	3	0.20	1.7e-05	5.3	6.1	1.1e-09	-0.07	0.02	0.90	FALSE
7	GTEx	Skin Not Sun Exposed Suprapubic	CNKSR1	0.15	0.10	lasso	7	0.09	1.0e-05	4.9	-6.0	2.0e-09	0.10	0.74	0.21	FALSE
4	GTEx	Nerve Tibial	PDIK1L	0.09	0.01	enet	10	0.03	2.2e-03	6.2	-5.9	3.0e-09	0.15	0.43	0.43	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	PDIK1L	0.03	0.01	blup	37	0.02	2.6e-03	6.0	-5.9	3.3e-09	0.05	0.01	0.55	FALSE
6	GTEx	Pituitary	CNKSR1	0.38	0.16	lasso	7	0.15	1.4e-04	4.9	-5.9	3.7e-09	0.12	0.27	0.21	FALSE
9	GTEx	Skin Sun Exposed Lower leg	PDIK1L	0.14	0.05	enet	23	0.12	3.1e-10	6.3	-5.9	4.0e-09	0.15	0.27	0.73	FALSE
5	GTEx	Pancreas	CNKSR1	0.20	0.03	enet	20	0.04	7.3e-03	6.0	-5.8	5.3e-09	0.27	0.11	0.20	FALSE
23	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PDIK1L	0.02	0.00	blup	37	0.02	1.2e-03	2.7	-5.7	1.0e-08	0.09	0.02	0.74	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIM63	0.11	0.11	enet	4	0.12	9.0e-14	6.3	5.6	1.8e-08	-0.07	0.01	0.99	FALSE
1	GTEx	Cells Transformed fibroblasts	DHDDS	0.13	0.09	lasso	4	0.08	1.0e-06	5.0	-5.4	7.2e-08	0.37	0.99	0.00	FALSE
8	GTEx	Skin Not Sun Exposed Suprapubic	PDIK1L	0.22	0.05	enet	37	0.11	8.3e-07	6.3	-5.4	8.0e-08	0.15	0.26	0.73	FALSE
11	GTEx	Thyroid	SEPN1	0.10	0.03	lasso	3	0.04	7.0e-04	-3.6	-5.3	1.5e-07	0.00	0.85	0.05	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	SH3BGRL3	0.05	0.03	lasso	2	0.03	9.3e-04	4.3	5.2	1.6e-07	-0.18	0.00	0.94	FALSE
12	METSIM	Adipose	RPS6KA1	0.04	0.01	bslmm	367	0.03	3.9e-05	4.8	5.2	2.5e-07	-0.12	0.84	0.02	FALSE