[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) :

chr1:25,475,418-27,595,862

Best TWAS P=6.28e-15 · Best GWAS P=1.61e-12 conditioned to 0.0173

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Cells Transformed fibroblasts DHDDS 0.13 0.09 lasso 4 0.08 1.0e-06 5.0 -5.4 7.2e-08 0.37 0.99 0.00 FALSE
2 GTEx Esophagus Mucosa DHDDS 0.11 0.06 lasso 4 0.04 6.6e-04 -6.8 -7.8 6.3e-15 0.60 0.01 0.99 TRUE
3 GTEx Esophagus Mucosa PDIK1L 0.10 0.09 lasso 6 0.09 8.8e-07 6.3 -6.3 2.4e-10 0.10 0.23 0.77 FALSE
4 GTEx Nerve Tibial PDIK1L 0.09 0.01 enet 10 0.03 2.2e-03 6.2 -5.9 3.0e-09 0.15 0.43 0.43 FALSE
5 GTEx Pancreas CNKSR1 0.20 0.03 enet 20 0.04 7.3e-03 6.0 -5.8 5.3e-09 0.27 0.11 0.20 FALSE
6 GTEx Pituitary CNKSR1 0.38 0.16 lasso 7 0.15 1.4e-04 4.9 -5.9 3.7e-09 0.12 0.27 0.21 FALSE
7 GTEx Skin Not Sun Exposed Suprapubic CNKSR1 0.15 0.10 lasso 7 0.09 1.0e-05 4.9 -6.0 2.0e-09 0.10 0.74 0.21 FALSE
8 GTEx Skin Not Sun Exposed Suprapubic PDIK1L 0.22 0.05 enet 37 0.11 8.3e-07 6.3 -5.4 8.0e-08 0.15 0.26 0.73 FALSE
9 GTEx Skin Sun Exposed Lower leg PDIK1L 0.14 0.05 enet 23 0.12 3.1e-10 6.3 -5.9 4.0e-09 0.15 0.27 0.73 FALSE
10 GTEx Thyroid CNKSR1 0.10 0.04 lasso 7 0.03 2.1e-03 6.0 -6.5 7.8e-11 0.15 0.40 0.52 FALSE
11 GTEx Thyroid SEPN1 0.10 0.03 lasso 3 0.04 7.0e-04 -3.6 -5.3 1.5e-07 0.00 0.85 0.05 FALSE
12 METSIM Adipose RPS6KA1 0.04 0.01 bslmm 367 0.03 3.9e-05 4.8 5.2 2.5e-07 -0.12 0.84 0.02 FALSE
13 The Cancer Genome Atlas Bladder Urothelial Carcinoma TRIM63 0.03 0.02 blup 33 0.02 4.6e-03 6.3 6.8 1.1e-11 -0.08 0.01 0.83 FALSE
14 The Cancer Genome Atlas Breast Invasive Carcinoma TRIM63 0.15 0.16 lasso 2 0.16 2.3e-32 6.3 6.4 2.0e-10 -0.07 0.01 0.99 FALSE
15 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma TRIM63 0.14 0.15 lasso 1 0.14 2.2e-07 6.3 6.3 2.4e-10 -0.07 0.01 0.99 FALSE
16 The Cancer Genome Atlas Colon Adenocarcinoma TRIM63 0.08 0.10 lasso 4 0.10 3.7e-06 6.3 6.6 4.2e-11 -0.08 0.01 0.99 FALSE
17 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PDIK1L 0.02 0.02 blup 37 0.02 2.8e-03 6.3 -6.2 5.7e-10 0.08 0.01 0.84 FALSE
18 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SLC30A2 0.03 0.02 lasso 3 0.01 1.1e-02 5.3 -6.3 3.6e-10 0.08 0.01 0.93 FALSE
19 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TRIM63 0.11 0.11 enet 4 0.12 9.0e-14 6.3 5.6 1.8e-08 -0.07 0.01 0.99 FALSE
20 The Cancer Genome Atlas Brain Lower Grade Glioma PDIK1L 0.03 0.01 blup 37 0.02 2.6e-03 6.0 -5.9 3.3e-09 0.05 0.01 0.55 FALSE
21 The Cancer Genome Atlas Brain Lower Grade Glioma TRIM63 0.29 0.33 enet 20 0.33 2.5e-38 6.3 7.0 2.3e-12 -0.07 0.01 0.99 TRUE
22 The Cancer Genome Atlas Lung Adenocarcinoma TRIM63 0.14 0.20 enet 7 0.21 9.4e-24 6.3 6.5 8.6e-11 -0.08 0.02 0.98 FALSE
23 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PDIK1L 0.02 0.00 blup 37 0.02 1.2e-03 2.7 -5.7 1.0e-08 0.09 0.02 0.74 FALSE
24 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TRIM63 0.16 0.11 lasso 1 0.10 2.0e-11 6.3 6.3 2.9e-10 -0.08 0.01 0.99 FALSE
25 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma TRIM63 0.14 0.18 lasso 7 0.15 3.0e-10 6.3 6.3 4.0e-10 -0.07 0.01 0.99 FALSE
26 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma RPS6KA1 0.11 0.05 lasso 6 0.07 8.0e-04 -6.4 7.3 2.8e-13 -0.73 0.01 0.85 FALSE
27 The Cancer Genome Atlas Prostate Adenocarcinoma SH3BGRL3 0.05 0.03 lasso 2 0.03 9.3e-04 4.3 5.2 1.6e-07 -0.18 0.00 0.94 FALSE
28 The Cancer Genome Atlas Rectum Adenocarcinoma TRIM63 0.28 0.22 lasso 3 0.20 1.7e-05 5.3 6.1 1.1e-09 -0.07 0.02 0.90 FALSE
29 The Cancer Genome Atlas Thyroid Carcinoma TRIM63 0.18 0.26 enet 7 0.26 3.0e-25 6.3 6.5 7.6e-11 -0.07 0.02 0.98 FALSE
30 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma TRIM63 0.19 0.07 blup 33 0.14 1.3e-04 6.3 6.3 3.2e-10 -0.06 0.01 0.98 FALSE