[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) : ← →

chr10:76,664,253-80,383,574

Best TWAS P=5.1e-15 · Best GWAS P=5.82e-18 conditioned to 1.04e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adrenal Gland DLG5 0.22 0.14 lasso 6 0.11 8.5e-05 -4.8 -5.7 1.2e-08 -0.04 0.02 0.96 TRUE
2 GTEx Brain Caudate basal ganglia C10orf11 0.35 0.27 lasso 4 0.25 9.8e-08 7.1 -7.2 6.8e-13 0.69 0.63 0.32 FALSE
3 GTEx Brain Cortex C10orf11 0.32 0.15 lasso 8 0.21 1.4e-06 7.2 -7.8 5.1e-15 0.77 0.38 0.57 TRUE
4 GTEx Brain Frontal Cortex BA9 C10orf11 0.33 0.18 enet 11 0.19 9.3e-06 7.1 -7.1 1.1e-12 0.70 0.47 0.38 FALSE
5 GTEx Muscle Skeletal C10orf11 0.11 0.13 lasso 3 0.12 5.1e-12 7.2 -7.4 9.8e-14 0.73 0.99 0.01 FALSE
6 GTEx Ovary DLG5 0.62 0.38 lasso 6 0.40 5.3e-11 -4.9 -5.4 6.4e-08 -0.01 0.02 0.98 FALSE
7 GTEx Ovary RP13-39P12.3 0.42 0.29 lasso 5 0.33 7.5e-09 -4.9 -5.5 3.1e-08 -0.01 0.01 0.98 FALSE
8 ROSMAP Brain Pre-frontal Cortex C10orf11 0.20 0.23 lasso 4 0.23 1.1e-29 7.2 -7.2 4.7e-13 0.69 1.00 0.00 FALSE
9 ROSMAP Brain Pre-frontal Cortex DLG5 0.19 0.17 bslmm 592 0.20 1.5e-24 -4.9 -5.2 2.4e-07 0.03 0.01 0.98 FALSE