Best TWAS P=5.08e-12 · Best GWAS P=9.36e-12 conditioned to 0.0632
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | DNAJC9-AS1 | 0.17 | 0.00 | enet | 50 | 0.02 | 1.9e-02 | 3.4 | -6.1 | 8.8e-10 | 0.01 | 0.05 | 0.04 | TRUE |
| 2 | GTEx | Artery Tibial | DUSP8P5 | 0.09 | 0.03 | enet | 8 | 0.03 | 2.0e-03 | 5.4 | 5.2 | 1.8e-07 | 0.80 | 0.22 | 0.49 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | CAMK2G | 0.06 | 0.04 | enet | 10 | 0.06 | 2.2e-05 | 6.7 | 6.4 | 1.5e-10 | 0.88 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Esophagus Mucosa | CAMK2G | 0.10 | 0.04 | lasso | 3 | 0.06 | 4.0e-05 | 5.4 | 5.5 | 4.7e-08 | 0.82 | 0.08 | 0.84 | FALSE |
| 5 | GTEx | Prostate | RP11-574K11.5 | 0.29 | 0.02 | enet | 43 | 0.00 | 2.4e-01 | 5.8 | -6.7 | 1.6e-11 | -0.62 | 0.02 | 0.42 | FALSE |
| 6 | GTEx | Spleen | MRPS16 | 0.50 | -0.01 | lasso | 6 | 0.02 | 1.1e-01 | 3.4 | 5.2 | 2.1e-07 | 0.08 | 0.01 | 0.05 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | MYOZ1 | 0.04 | 0.01 | blup | 235 | 0.02 | 2.6e-03 | -4.6 | 6.0 | 1.6e-09 | 0.52 | 0.18 | 0.51 | FALSE |
| 8 | YFS | Blood | FUT11 | 0.02 | 0.00 | bslmm | 231 | 0.01 | 2.0e-03 | 6.7 | -5.3 | 1.1e-07 | -0.70 | 0.01 | 0.97 | FALSE |
| 9 | YFS | Blood | NDST2 | 0.10 | 0.09 | lasso | 14 | 0.10 | 5.0e-30 | 6.8 | -6.8 | 7.6e-12 | -0.98 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | BMS1P4 | 0.05 | 0.01 | enet | 4 | 0.02 | 8.4e-03 | 6.6 | -5.4 | 7.9e-08 | -0.90 | 0.00 | 0.92 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CHCHD1 | 0.02 | 0.01 | lasso | 2 | 0.01 | 2.5e-03 | 6.7 | 6.7 | 2.7e-11 | 0.94 | 0.01 | 0.94 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SEC24C | 0.04 | 0.02 | blup | 29 | 0.03 | 2.6e-06 | 6.7 | 6.9 | 5.1e-12 | 0.86 | 0.01 | 0.99 | TRUE |
| 13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SEC24C | 0.07 | 0.07 | blup | 29 | 0.07 | 9.4e-05 | -4.6 | 5.6 | 2.6e-08 | 0.35 | 0.28 | 0.08 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | SEC24C | 0.02 | 0.01 | enet | 4 | 0.01 | 8.5e-03 | -4.6 | 6.2 | 4.9e-10 | 0.50 | 0.05 | 0.16 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NDST2 | 0.03 | 0.02 | blup | 37 | 0.02 | 3.3e-03 | -4.2 | -5.7 | 1.3e-08 | -0.38 | 0.27 | 0.11 | FALSE |
| 16 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | BMS1P4 | 0.21 | 0.08 | enet | 15 | 0.08 | 2.3e-03 | 6.6 | -6.2 | 5.2e-10 | -0.80 | 0.00 | 0.81 | FALSE |