TWAS
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Forced expiratory volume in 1-second (FEV1)
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chr11:32,365,430-33,799,671
Best TWAS P=7.86e-09 · Best GWAS P=3.41e-07 conditioned to 0.84
32.4M
32.6M
32.8M
33M
33.2M
33.4M
33.6M
33.8M
0
2
4
6
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
5
The Cancer Genome Atlas
Thyroid Carcinoma
TCP11L1
0.11
0.04
blup
76
0.08
1.2e-08
-4.9
-5.8
7.9e-09
-0.87
0.02
0.97
TRUE
2
GTEx
Cells Transformed fibroblasts
TCP11L1
0.17
0.07
enet
15
0.14
2.5e-10
3.0
-5.6
2.4e-08
-0.68
0.05
0.93
FALSE
4
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
LOC283267
0.05
0.02
blup
50
0.04
6.0e-05
-4.9
-5.5
4.5e-08
-0.82
0.02
0.96
FALSE
3
GTEx
Thyroid
PIGCP1
0.14
0.11
enet
32
0.11
4.8e-09
-4.9
-5.3
1.4e-07
-0.61
0.02
0.97
FALSE
1
GTEx
Brain Frontal Cortex BA9
PIGCP1
0.36
0.05
enet
35
0.07
7.5e-03
-4.7
-5.1
2.8e-07
-0.61
0.02
0.88
FALSE