Best TWAS P=7.64e-08 · Best GWAS P=6.03e-08 conditioned to 0.000333
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Transverse | C1QTNF4 | 0.07 | 0.02 | lasso | 6 | 0.03 | 2.0e-02 | -5.2 | 5.3 | 1.2e-07 | 0.25 | 0.02 | 0.93 | FALSE |
| 2 | GTEx | Muscle Skeletal | MTCH2 | 0.05 | 0.03 | enet | 15 | 0.04 | 1.5e-04 | -4.5 | -5.3 | 1.2e-07 | -0.37 | 0.03 | 0.96 | FALSE |
| 3 | GTEx | Muscle Skeletal | C1QTNF4 | 0.09 | 0.14 | lasso | 3 | 0.13 | 9.9e-13 | -5.1 | 5.2 | 1.6e-07 | 0.26 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Whole Blood | C1QTNF4 | 0.09 | 0.05 | lasso | 3 | 0.03 | 1.4e-03 | -5.1 | 5.2 | 2.6e-07 | 0.22 | 0.02 | 0.97 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | ACP2 | 0.03 | 0.00 | blup | 295 | 0.02 | 1.5e-03 | -4.2 | -5.1 | 3.0e-07 | -0.64 | 0.20 | 0.51 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | C1QTNF4 | 0.05 | 0.06 | blup | 281 | 0.06 | 1.7e-08 | -4.3 | 5.4 | 7.6e-08 | 0.39 | 0.05 | 0.95 | TRUE |
| 7 | YFS | Blood | PSMC3 | 0.02 | 0.01 | blup | 289 | 0.01 | 2.8e-05 | -5.2 | -5.1 | 2.8e-07 | -0.36 | 0.02 | 0.96 | FALSE |
| 8 | The Cancer Genome Atlas | Esophageal Carcinoma | C1QTNF4 | 0.39 | 0.33 | blup | 15 | 0.35 | 6.1e-12 | -5.1 | 5.2 | 2.4e-07 | 0.25 | 0.00 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | C1QTNF4 | 0.03 | 0.02 | blup | 15 | 0.02 | 1.3e-03 | -5.1 | 5.4 | 8.1e-08 | 0.27 | 0.00 | 0.94 | FALSE |