TWAS hub - LOC283267

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.0470	0.0280	8.8e-03	0.006	0.024	0.012	NA	0.013	9.1e-02	4.0e-03	2.8e-02	NA	2.6e-02
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0496	0.0261	4.9e-05	0.023	0.036	0.032	NA	0.033	1.1e-03	6.0e-05	1.4e-04	NA	1.2e-04
3	TCGA	Brain Lower Grade Glioma	0.0392	0.0203	1.5e-04	0.045	0.031	0.034	NA	0.035	7.2e-06	1.7e-04	8.2e-05	NA	6.2e-05
4	TCGA	Pheochromocytoma and Paraganglioma	0.1360	0.0750	3.3e-04	0.110	0.092	0.064	NA	0.090	4.0e-05	1.7e-04	1.6e-03	NA	1.9e-04
5	TCGA	Prostate Adenocarcinoma	0.1918	0.0869	1.2e-12	0.087	0.124	0.115	NA	0.132	2.4e-09	6.0e-13	4.7e-12	NA	1.2e-13

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Peak expiratory flow (PEF)	6.2	14.4	20.8	-2.7	-4.6	-3.2	-4.1	-4.1
Forced vital capacity (FVC)	5.9	22.8	35.9	-3.5	-6.0	-4.1	-5.0	-4.9
Chronotype (morning person)	5.8	13.4	14.7	3.7	3.7	3.8	3.5	3.6
Type 2 Diabetes (T2D) (2012)	5.7	6.6	9.4	1.9	2.5	2.6	2.6	3.1
Worrier / anxious feelings	5.4	10.3	12.1	-2.7	-3.0	-3.5	-3.3	-3.5
Forced expiratory volume in 1-second (FEV1)	4.9	16.4	29.9	-2.5	-5.5	-3.1	-4.2	-4.3
Forced expiratory volume in 1-second (FEV1), Best measure	4.7	15.0	25.0	-2.6	-5.0	-3.3	-4.0	-4.1
Stomach or abdominal pain in last month	4.4	5.4	6.1	-2.5	-2.4	-2.5	-2.1	-2.2
Mean Putamen Volume	4.2	4.8	6.5	-1.8	-1.7	-2.2	-2.5	-2.5
Qualifications: CSEs or equivalent	4.2	5.6	6.2	-2.4	-2.2	-2.5	-2.4	-2.3
Number of incorrect matches in round	4.2	6.9	12.2	1.8	3.5	2.4	2.4	2.7
Forced vital capacity (FVC), Best measure	4.0	14.6	23.7	-2.7	-4.9	-3.4	-3.9	-3.9
Medication: Lisinopril	3.9	5.1	6.2	1.7	2.5	2.2	2.3	2.5
Rheumatoid Arthritis	3.7	5.1	5.9	1.9	2.2	2.3	2.4	2.4
Relative age voice broke	3.7	5.6	7.0	2.0	2.4	2.2	2.6	2.6
Pack years of smoking	3.7	5.5	7.1	2.1	1.8	2.7	2.4	2.6
Pack years adult smoking proportion	3.5	5.3	7.1	1.9	1.8	2.6	2.4	2.7
Impedance of leg (right)	3.1	14.8	18.4	2.8	4.2	3.5	4.3	4.2
Ulcerative Colitis	2.9	4.2	5.5	2.4	1.4	2.2	2.2	2.0
Vitamin and mineral supplements	2.8	3.8	4.7	-1.7	-2.1	-1.7	-2.2	-2.1
Average weekly fortified wine intake	2.8	3.3	6.3	-0.7	-2.5	-1.7	-1.7	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.6	3.1	4.2	-1.4	-1.8	-1.7	-1.8	-2.1
Neuroticism (2016)	2.5	3.5	7.6	-1.0	-2.8	-1.4	-1.8	-2.0
Medication: Aspirin	2.5	3.3	4.1	1.7	1.6	1.8	2.0	2.0
Ever used hormone-replacement therapy (HRT)	2.4	3.0	5.2	-2.3	-1.6	-1.9	-1.4	-1.4
Impedance of leg (left)	2.4	11.6	15.2	2.5	3.7	3.0	3.9	3.8
Suffer from ‘nerves’	2.4	3.8	5.1	-1.6	-2.3	-1.8	-2.0	-2.0
Supplements: Glucosamine	2.3	3.1	5.4	-0.5	-2.3	-1.4	-1.9	-2.0
Average weekly spirits intake	2.2	2.8	3.6	1.5	1.4	1.9	1.7	1.8
Relative age of first facial hair	2.2	4.5	5.9	1.9	2.3	1.6	2.4	2.3
Had other major operations	2.2	2.7	3.2	-1.8	-1.7	-1.7	-1.5	-1.5
Medication: Aspirin	2.2	2.9	4.2	1.2	1.7	1.5	2.0	2.0
Leg fat-free mass (right)	2.2	11.6	13.4	-3.2	-3.5	-3.2	-3.7	-3.4
Leg predicted mass (right)	2.2	11.9	13.7	-3.2	-3.6	-3.2	-3.7	-3.4
Tinnitus: Yes, now most or all of the time	2.2	2.6	2.8	-1.5	-1.5	-1.7	-1.7	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.3	10.8	-0.7	-3.3	-1.3	-2.0	-2.1
Irritability	2.0	3.4	4.5	2.1	1.3	2.0	1.9	1.8
Risk taking	2.0	2.9	3.4	1.6	1.5	1.9	1.7	1.8
Heart attack/myocardial infarction (self-reported)	2.0	2.6	4.0	1.4	2.0	1.4	1.6	1.7
Heart disease (siblings)	2.0	2.5	3.1	1.3	1.6	1.6	1.6	1.8
Reaction Time	1.9	3.7	6.7	0.3	2.6	1.0	2.2	2.4
Lung FVC	1.9	9.8	24.8	-0.9	-5.0	-1.7	-3.1	-3.3
Heart attack	1.9	2.4	4.0	1.3	2.0	1.3	1.5	1.6
Back pain experienced in last month	1.9	2.7	3.3	1.7	1.0	1.8	1.8	1.8
Alzheimer’s Disease (in mother)	1.8	2.1	5.5	2.4	-0.9	1.9	0.5	0.4
Ovarian Cancer	1.8	2.3	3.2	-1.7	-0.7	-1.8	-1.6	-1.5
Bilateral oophorectomy (both ovaries removed)	1.8	2.0	3.3	-1.4	-1.8	-1.1	-1.4	-1.3
Diabetes (self-reported)	1.8	2.7	3.6	1.2	1.4	1.8	1.9	1.9
Arm fat-free mass (right)	1.8	9.5	12.0	-2.8	-3.5	-3.0	-3.1	-3.1
Mean time to correctly identify matches	1.8	3.4	6.2	0.5	2.5	1.1	2.1	2.2
Whole body fat-free mass	1.8	10.3	11.4	-3.0	-3.3	-3.1	-3.4	-3.2
Whole body water mass	1.8	10.4	11.6	-3.0	-3.4	-3.1	-3.4	-3.3
Lupus	1.7	2.6	4.1	1.0	1.6	1.5	1.8	2.0
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	2.8	-1.3	-1.3	-1.6	-1.5	-1.7
Had menopause	1.7	2.1	2.8	-1.1	-1.4	-1.4	-1.6	-1.7
Trunk fat-free mass	1.7	9.5	10.4	-2.7	-3.2	-3.0	-3.2	-3.2
Trunk predicted mass	1.7	9.5	10.4	-2.7	-3.2	-3.0	-3.2	-3.2
Handedness (chirality/laterality): Left-handed	1.7	2.0	2.3	-1.2	-1.5	-1.5	-1.5	-1.5
Arm predicted mass (left)	1.7	8.5	10.0	-2.6	-3.2	-2.8	-3.0	-3.0
Leg fat-free mass (left)	1.6	8.2	9.5	-2.9	-2.9	-2.7	-3.1	-2.8
Multivitamins +/- minerals	1.6	2.0	2.8	1.2	1.7	1.1	1.5	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	3.6	-1.9	-0.8	-1.6	-1.2	-0.9
Leg fat percentage (right)	1.6	5.8	8.5	1.1	2.9	2.0	2.6	2.9
Arm predicted mass (right)	1.6	8.0	10.6	-2.5	-3.2	-2.7	-2.9	-2.8
Impedance of whole body	1.6	8.0	11.9	1.8	3.5	2.4	3.1	3.1
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	2.8	0.8	0.9	1.3	1.7	1.6
Hand grip strength (right)	1.5	4.2	6.1	-1.2	-2.5	-1.9	-2.1	-2.3
Leg predicted mass (left)	1.5	8.0	9.3	-2.9	-2.8	-2.7	-3.0	-2.7
Alcohol intake versus 10 years previously	1.5	2.2	3.1	-1.8	-1.1	-1.6	-1.5	-1.4
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	3.5	1.6	0.9	1.5	1.9	1.8
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	3.1	1.8	1.0	1.6	1.2	0.9
Financial situation satisfaction	1.5	1.8	3.3	-1.5	-1.0	-1.8	-1.1	-1.2
Basal metabolic rate	1.5	8.1	8.8	-2.8	-2.9	-2.8	-3.0	-2.8
Ever had hysterectomy (womb removed)	1.4	1.6	3.0	-0.9	-1.7	-0.8	-1.4	-1.4
Diabetes (father)	1.4	1.8	3.0	1.7	0.9	1.7	1.1	1.1
Gout (self-reported)	1.4	2.0	3.8	1.9	0.2	1.6	1.5	1.1
Medication for pain relief, constipation, heartburn	1.4	2.5	3.6	-1.5	-0.8	-1.9	-1.6	-1.7
Financial difficulties in last 2 years	1.3	1.8	2.4	-1.5	-1.3	-1.4	-1.2	-1.1
Ever highly irritable/argumentative for 2 days	1.3	1.5	3.2	1.8	0.5	1.5	1.1	0.9
Comparative height size at age 10	1.3	7.4	10.5	-2.4	-2.4	-2.5	-3.2	-3.0
Diabetes diagnosed by doctor	1.3	2.1	3.3	0.7	1.3	1.4	1.8	1.8
Type 2 Diabetes (T2D) (2018)	1.2	2.3	3.0	1.2	1.4	1.5	1.7	1.7
Hand grip strength (left)	1.2	3.2	5.2	-1.1	-2.3	-1.7	-1.7	-2.0
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	1.6	-1.1	-1.0	-1.1	-1.3	-1.2
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.0	-1.2	-1.7	-1.0	-0.9	-1.0
Medication: Simvastatin	1.2	1.8	2.3	1.2	1.5	1.1	1.5	1.4
Illnesses of siblings	1.2	1.7	2.0	-1.1	-1.4	-1.1	-1.4	-1.4
Number of full sisters	1.2	1.4	2.9	-1.0	-1.7	-1.0	-1.1	-1.1
Arm fat-free mass (left)	1.2	6.1	8.1	-2.1	-2.8	-2.3	-2.5	-2.5
Unable to work because of sickness or disability	1.2	1.6	2.6	0.1	1.6	0.6	1.5	1.6
Townsend deprivation index at recruitment	1.1	1.5	3.7	-0.9	-1.9	-0.8	-1.2	-1.1
Medication: Seretide 50 evohaler	1.1	1.2	2.6	1.6	0.4	1.5	0.8	0.8
Heart disease (mother)	1.1	1.4	1.7	-1.1	-1.3	-1.3	-1.1	-1.0
Average weekly red wine intake	1.1	1.7	2.7	-0.3	-1.6	-1.1	-1.4	-1.6
Ever had bowel cancer screening	1.1	1.3	3.1	-0.5	-1.8	-0.7	-1.1	-1.2
Osteoarthritis (self-reported)	1.1	1.5	1.8	-1.0	-1.1	-1.3	-1.3	-1.4
Bipolar Disorder (2018)	1.0	1.6	1.8	1.0	1.3	1.3	1.4	1.3
Alzheimer’s Disease (including proxy)	1.0	1.4	4.0	2.0	-0.6	1.5	0.6	0.4
Taking other prescription medications	1.0	1.5	2.0	1.0	1.4	1.1	1.2	1.3
Tense / ‘highly strung’	1.0	1.7	2.5	1.6	0.5	1.6	1.4	1.3
Alcohol intake frequency.	1.0	2.4	3.6	-1.9	-1.0	-1.6	-1.7	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.9	-1.1	-1.0	-1.4	-1.0	-1.0
Leg fat percentage (left)	1.0	3.6	5.3	0.8	2.3	1.5	2.1	2.3
Basal cell carcinoma (self-reported)	1.0	1.2	3.3	-0.4	-1.8	-0.8	-0.7	-1.1
Worry (Nagel 2018)	0.9	1.9	2.4	-1.6	-1.3	-1.5	-1.2	-1.3
Angina	0.9	1.2	1.5	1.1	0.7	1.2	1.1	1.1
Severe depression (siblings)	0.9	1.0	1.5	-0.4	-1.0	-0.9	-1.1	-1.2
Sitting height	0.9	6.5	12.9	-3.6	-1.7	-3.0	-2.0	-1.9
Mouth/teeth dental problems	0.9	1.4	2.6	-1.6	-0.8	-1.4	-1.0	-0.9
Standing height	0.9	8.7	9.5	-2.9	-2.7	-3.0	-3.1	-3.0
Chronic bronchitis/emphysema (mother)	0.9	1.0	1.3	0.8	1.0	1.1	1.0	1.1
Number of full brothers	0.9	1.1	1.9	1.3	0.5	1.4	0.9	0.9
Angina (self-reported)	0.9	1.2	1.7	1.1	0.7	1.3	1.1	1.1
Knee pain experienced in last month	0.9	1.4	2.6	-0.5	-1.6	-1.0	-1.2	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.2	0.7	0.9	1.2	1.4	1.5
Mineral and other dietary supplements	0.9	1.2	1.6	0.7	1.3	1.1	1.1	1.2
Guilty feelings	0.9	1.3	2.0	-1.2	-0.3	-1.4	-1.2	-1.2
Medication: Bendroflumethiazide	0.9	1.3	2.5	1.0	1.6	1.1	0.9	1.0
Prostate Cancer	0.8	1.1	1.4	-0.8	-1.2	-0.9	-1.2	-1.2
Body Mass Index (BMI) (2010)	0.8	1.1	2.5	1.6	0.7	1.3	0.6	0.5
BMI	0.8	4.5	6.0	1.4	2.2	2.2	2.2	2.4
Medication: Metformin	0.8	1.2	1.5	0.8	1.0	1.2	1.2	1.2
Maternal smoking around birth	0.8	1.1	4.6	0.1	-2.1	-0.0	-0.7	-0.6
Alcohol usually taken with meals	0.8	1.4	3.7	1.9	1.0	1.2	0.7	0.4
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.2	-0.7	-1.5	-0.8	-0.9	-1.1
Impedance of arm (right)	0.8	3.6	8.0	0.9	2.8	1.4	1.8	2.0
Medication: Ibuprofen	0.8	1.0	1.2	1.0	0.8	1.1	1.0	1.0
Medication: Gliclazide	0.8	0.9	1.3	-0.9	-1.1	-1.0	-0.9	-0.9
High cholesterol (Self-reported)	0.8	1.5	2.6	1.0	1.6	1.0	1.2	1.2
Number of operations (self-reported)	0.8	1.2	2.2	-1.1	-1.5	-1.0	-0.8	-0.9
Vascular/heart problems diagnosed by doctor	0.8	2.2	3.3	-0.8	-1.8	-1.3	-1.6	-1.7
Cholesterol lowering medication	0.8	1.2	2.0	0.2	1.4	0.6	1.3	1.3
Alcohol drinker status: Previous	0.8	0.9	1.5	0.3	1.0	0.8	1.1	1.2
Depression (Nagel 2018)	0.7	1.1	1.7	0.9	0.4	1.0	1.3	1.2
Primary Biliary Cirrhosis	0.7	1.1	1.8	1.3	0.8	1.2	0.9	0.8
Medication: Co-codamol	0.7	0.8	1.5	-1.2	-0.7	-0.7	-1.0	-0.7
Diabetes (mother)	0.7	0.9	2.0	-1.2	-0.5	-1.4	-0.7	-0.6
Serious illness, injury or assault to yourself	0.7	0.8	1.4	-0.6	-1.2	-0.7	-1.0	-1.0
Past tobacco smoking	0.7	1.4	1.7	1.1	1.3	1.3	0.9	1.1
Asthma	0.7	1.4	2.8	0.6	1.7	0.8	1.2	1.3
Prospective memory result	0.7	0.9	2.3	0.1	1.5	0.1	1.0	1.0
Blood clot in the leg (DVT)	0.7	0.9	2.3	-0.1	0.7	0.7	1.2	1.5
Body fat percentage	0.7	2.6	4.6	0.1	2.1	1.2	1.7	2.0
Myopia	0.7	1.1	1.6	-1.0	-0.5	-1.0	-1.3	-1.1
HDL Cholesterol	0.6	0.9	1.4	-0.7	-1.2	-0.6	-1.1	-1.1
Blood White Count	0.6	4.1	6.2	0.8	2.5	1.5	2.3	2.4
Respiratory disease	0.6	1.3	2.2	1.1	1.5	1.0	0.9	1.1
Sensitivity / hurt feelings	0.6	1.1	1.4	-1.0	-1.1	-0.8	-1.2	-1.0
Chronic bronchitis/emphysema (father)	0.6	0.7	1.1	-0.5	-1.1	-0.8	-0.9	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.3	1.1	0.6	1.1	1.0	1.1
Pain all over the body in last month	0.6	0.7	1.1	-1.0	-0.8	-1.1	-0.5	-0.5
Father’s age at death	0.6	0.8	1.5	-0.5	-0.4	-0.9	-1.2	-1.2
Illnesses of mother	0.6	0.8	1.2	0.5	1.1	0.5	1.1	0.9
Impedance of arm (left)	0.6	2.6	5.9	0.7	2.4	1.2	1.5	1.7
Breastfed as a baby	0.6	0.8	1.1	-0.9	-0.7	-0.9	-1.0	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.4	-0.7	-0.9	-0.9	-1.1	-1.2
High blood pressure (siblings)	0.6	0.9	1.5	0.4	0.9	0.7	1.2	1.2
Eye problems/disorders: None of the above	0.6	0.7	1.6	-0.3	-1.3	-0.5	-1.0	-0.9
Supplements: Vitamin C	0.6	0.7	1.1	0.6	0.9	0.8	1.0	0.9
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.0	-0.2	0.6	0.7	1.1	1.4
Breast Cancer	0.5	1.2	1.6	-0.9	-1.2	-0.9	-1.3	-1.2
Bipolar Disorder (2011)	0.5	0.4	0.9	0.3	0.9	0.5	0.6	0.8
Crohns Disease (2012)	0.5	0.7	1.2	1.0	0.6	0.8	1.1	0.7
Neuroticism	0.5	1.1	1.5	-1.2	-1.1	-1.1	-0.9	-1.0
High blood pressure	0.5	1.3	2.0	0.6	1.4	1.1	1.2	1.2
Nervous feelings	0.5	1.0	1.5	-0.6	-0.9	-0.9	-1.2	-1.2
Worry too long after embarrassment	0.5	0.9	1.9	-0.2	-1.4	-0.5	-1.0	-1.1
Chest pain or discomfort	0.5	0.7	1.8	-1.3	-0.7	-0.8	-0.6	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	0.9	0.2	1.1	0.6	0.6
Eye problems/disorders: Cataract	0.5	0.6	1.3	-0.2	1.1	0.2	0.9	0.9
Ever smoked	0.5	0.9	1.3	-0.9	-1.2	-0.9	-0.8	-0.9
Triglycerides	0.4	0.6	0.8	-0.9	-0.7	-0.8	-0.7	-0.7
Blood Eosinophil Count	0.4	3.0	3.9	1.7	2.0	1.8	1.5	1.6
Blood Red Count	0.4	4.2	9.3	-1.1	-3.0	-1.3	-2.0	-2.2
Heel T-Score	0.4	3.3	5.3	1.7	1.3	1.6	2.3	2.1
Height	0.4	7.2	8.7	-2.5	-2.5	-2.6	-2.9	-3.0
Waist Hip Ratio (WHR)	0.4	1.8	2.7	0.8	1.0	1.3	1.6	1.6
Tanning	0.4	4.7	7.3	2.7	1.2	2.5	2.2	1.8
Number of treatments/medications taken	0.4	0.7	1.0	0.7	0.8	0.6	1.0	0.9
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.8	0.7	0.4	0.7	0.9	0.9
Trunk fat percentage	0.4	1.7	3.3	-0.1	1.8	0.9	1.3	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.3	1.5	0.4	0.9	1.0	0.7
Weight	0.4	2.2	3.8	-1.9	-1.1	-1.5	-1.5	-1.2
Hip circumference	0.4	1.7	3.1	-1.8	-0.7	-1.4	-1.3	-1.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.7	1.3	1.0	1.1	0.5	0.5
Mouth/teeth dental problems: Dentures	0.4	0.8	1.8	1.3	0.9	0.8	0.6	0.4
Length of working week for main job	0.4	0.5	1.0	-0.6	-1.0	-0.4	-0.6	-0.6
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.2	-0.2	-0.9	-0.6	-1.0	-1.1
Medication: Amlodipine	0.4	0.6	0.9	-0.4	-1.0	-0.6	-0.8	-0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.2	1.1	0.3	0.9	0.5	0.2
Neck or shoulder pain in last month	0.4	0.5	1.1	0.4	1.0	0.4	0.8	0.8
Medication: Omeprazole	0.4	0.4	0.8	0.3	0.5	0.8	0.6	0.9
Pulse rate, automated reading	0.4	1.2	2.7	0.1	1.6	0.4	1.2	1.3
Asthma (self-reported)	0.4	0.8	1.8	0.3	1.4	0.5	0.8	1.0
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	1.0	0.3	0.9	0.7	0.5
Ever depressed for a whole week	0.4	0.5	0.9	-0.3	-0.9	-0.4	-0.8	-1.0
Schizophrenia (2018)	0.3	0.7	1.2	-0.2	-1.1	-0.6	-0.9	-1.0
Ulcerative Colitis (UC)	0.3	0.5	0.7	0.8	0.6	0.6	0.8	0.8
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.6	1.1	0.4	1.3	0.6	0.6
Cardiovascular Disease	0.3	0.9	1.4	0.3	1.1	0.8	1.1	1.2
Hypothyroidism (self reported)	0.3	0.7	1.1	0.3	1.1	0.4	1.0	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.5	1.2	0.1	0.8	0.8	0.6
Medication: Levothyroxine sodium	0.3	0.5	0.9	0.5	0.8	0.3	1.0	0.8
Neuroticism score	0.3	0.5	0.8	-0.9	-0.7	-0.8	-0.6	-0.6
Arm fat percentage (right)	0.3	1.3	3.2	-0.2	1.8	0.7	1.1	1.4
Time employed in main current job	0.3	0.3	0.7	-0.1	-0.5	-0.5	-0.7	-0.8
Pulse rate	0.3	0.5	1.3	-0.1	1.1	0.0	0.8	0.7
Noisy workplace	0.3	0.3	0.7	-0.8	0.6	-0.5	0.5	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.9	1.0	0.2	0.8	0.5	0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	0.8	-0.0	0.7	0.6	0.4
Arm fat percentage (left)	0.3	1.1	2.5	-0.2	1.6	0.6	1.0	1.3
Loneliness, isolation	0.3	0.3	0.4	0.6	0.5	0.5	0.6	0.6
Osteoporosis (self-reported)	0.3	0.4	1.3	1.1	0.2	0.7	0.2	-0.0
Number of self-reported non-cancer illnesses	0.3	0.4	0.9	-0.8	-0.1	-0.9	-0.6	-0.6
Miserableness	0.3	0.6	1.0	0.5	0.4	1.0	0.9	0.9
Wears glasses or contact lenses	0.3	0.3	0.5	-0.7	0.0	-0.5	-0.7	-0.6
Hearing aid user	0.3	0.3	0.8	0.2	0.9	0.3	0.5	0.5
Mother’s age at death	0.3	0.4	0.8	-0.3	0.7	0.7	0.4	0.9
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	-0.9	-0.4	-0.6	-0.7	-0.5
Average weekly beer plus cider intake	0.3	0.4	0.7	-0.8	-0.6	-0.9	-0.3	-0.4
Age started oral contraceptive pill	0.3	0.4	0.6	-0.7	-0.2	-0.8	-0.6	-0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.8	0.3	-0.9	0.0	-0.2	-0.3
Irritable Bowel Disease (IBD)	0.2	0.4	0.6	0.6	0.4	0.5	0.8	0.6
Coronary Artery Disease (CAD)	0.2	0.2	0.6	-0.2	0.3	0.1	0.8	0.6
Fasting Glucose	0.2	0.2	0.3	0.3	0.5	0.3	0.6	0.5
Blood Platelet Count	0.2	2.4	3.8	-1.0	-1.4	-1.6	-1.6	-1.9
Lung FEV1/FVC ratio	0.2	0.9	1.8	1.2	-0.1	1.4	0.7	0.6
Hearing difficulty/problems: Yes	0.2	0.3	0.8	-0.9	0.2	-0.3	-0.6	-0.2
Medication for hormone replacement therapy	0.2	0.3	0.4	0.3	0.3	0.5	0.7	0.6
Current tobacco smoking	0.2	0.3	0.7	0.5	0.5	0.9	0.3	0.6
Age when periods started (menarche)	0.2	0.5	1.0	0.4	0.2	0.6	1.0	0.9
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.5	-0.7	-0.7	-0.6	-0.6	-0.5
Medication: Atenolol	0.2	0.2	0.7	-0.9	0.3	-0.0	0.4	0.5
High blood pressure (mother)	0.2	0.3	0.8	0.9	-0.1	0.7	0.3	0.2
Hearing difficulty/problems with background noise	0.2	0.4	1.1	-0.1	1.1	0.6	0.1	0.6
Medication: Ramipril	0.2	0.3	0.4	0.6	-0.6	0.6	0.4	0.4
Number of live births	0.2	0.2	0.8	0.4	-0.9	0.2	-0.1	-0.2
Depression (self-reported)	0.2	0.2	0.6	-0.3	0.8	-0.1	0.5	0.5
Medication: Lansoprazole	0.2	0.2	0.6	-0.8	0.3	-0.2	0.2	0.3
Lung cancer (father)	0.2	0.2	0.5	-0.7	-0.3	-0.6	-0.0	0.0
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	-0.8	0.1	-0.5	-0.4	-0.2
Glaucoma (self-reported)	0.2	0.2	0.5	0.7	-0.6	0.3	-0.1	-0.4
Birth weight	0.2	0.4	1.3	0.4	-1.1	0.1	-0.4	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	-0.3	-0.0	-0.7	-0.5	-0.6
Age at first live birth	0.2	0.3	0.9	1.0	0.3	0.7	0.2	0.0
Medication: Blood pressure	0.2	0.4	0.8	0.0	0.7	0.5	0.7	0.9
Migraine (self-reported)	0.2	0.3	0.4	0.6	-0.4	0.7	0.4	0.4
Medication: Allopurinol	0.2	0.3	0.5	0.7	-0.5	0.5	0.4	0.3
Leg fat mass (right)	0.2	0.9	1.8	-0.2	1.2	0.6	1.0	1.3
Age at last live birth	0.2	0.3	0.8	0.9	0.6	0.7	0.2	0.0
Family relationship satisfaction	0.2	0.2	0.5	-0.3	-0.1	-0.7	-0.4	-0.5
Leg pain on walking	0.2	0.2	0.5	-0.4	-0.7	-0.5	-0.4	-0.3
Hypertension (Self-reported)	0.2	0.5	1.1	0.0	1.0	0.5	0.7	0.8
Illnesses of father: Heart disease	0.2	0.3	0.5	0.0	0.6	0.2	0.6	0.7
Qualifications: nursing, teaching	0.2	0.4	0.7	-0.4	-0.2	-0.6	-0.8	-0.8
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	0.4	0.7	0.2	0.5	0.4
Smoking status: Current	0.2	0.3	0.6	-0.5	-0.5	-0.2	-0.8	-0.5
Ever taken oral contraceptive pill	0.2	0.2	0.6	-0.8	-0.2	-0.5	-0.0	0.0
Medication: Blood pressure	0.2	0.4	0.7	0.7	0.4	0.9	0.5	0.4
Illnesses of father: High blood pressure	0.2	0.2	0.5	-0.5	0.7	0.1	0.2	0.4
Alcohol drinker status: Never	0.2	0.3	0.7	-0.8	0.5	-0.7	0.1	0.1
Fractured/broken bones in last 5 years	0.2	0.2	0.3	-0.6	0.6	-0.2	0.4	0.5
Diastolic blood pressure, automated reading	0.2	0.5	0.7	-0.6	-0.4	-0.9	-0.8	-0.8
Commuting to job workplace: Cycle	0.2	0.3	0.5	0.3	-0.5	-0.3	-0.7	-0.7
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	-0.6	0.4	-0.1	0.4	0.4
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.6	0.8	0.0	0.5	-0.3	-0.3
Neuroticism (Nagel 2018)	0.1	0.3	0.8	-0.9	-0.6	-0.4	-0.4	-0.3
Schizophrenia vs Biploar Disorder	0.1	0.2	0.6	0.8	-0.0	0.4	0.1	0.0
Major Depression (MDD)	0.1	0.1	0.2	-0.0	-0.3	-0.1	-0.4	-0.4
HbA1C	0.1	0.2	0.4	0.7	-0.3	0.3	-0.2	-0.4
LDL Cholesterol	0.1	0.2	0.4	-0.5	-0.6	-0.4	-0.5	-0.4
Systolic Blood Pressure	0.1	0.4	1.2	0.1	1.1	0.2	0.7	0.6
Supplements: Zinc	0.1	0.1	0.1	-0.3	0.3	-0.3	0.1	0.0
Fed-up feelings	0.1	0.2	0.5	-0.6	-0.7	-0.4	-0.2	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.8	0.2	-0.9	0.0	0.0	-0.1
Trunk fat mass	0.1	0.3	0.8	-0.9	0.7	-0.1	0.2	0.6
Waist circumference	0.1	0.3	1.3	-1.1	-0.1	-0.5	-0.2	0.0
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.4	-0.1	-0.4	-0.3	-0.3
Allergy	0.1	0.3	0.7	-0.1	-0.5	-0.4	-0.6	-0.9
Falls in the last year	0.1	0.1	0.3	-0.4	-0.5	-0.3	-0.2	-0.2
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.3	0.2	0.3	0.4	0.3
Medication: Cholesterol lowering	0.1	0.2	0.3	0.4	0.3	0.5	0.5	0.5
Arm fat mass (right)	0.1	0.3	1.0	-1.0	0.4	-0.3	-0.1	0.2
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.5	-0.3	0.2	0.1	0.0
Birth weight of first child	0.1	0.2	0.3	-0.3	-0.2	-0.6	-0.4	-0.5
Pulse wave reflection index	0.1	0.1	0.2	0.2	-0.4	-0.0	-0.4	-0.5
Loud music exposure frequency	0.1	0.1	0.4	0.3	0.1	-0.4	-0.3	-0.6
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.3	0.2	0.6	0.3	-0.1	0.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.4	0.6	-0.6	0.2	0.0	-0.1
Exposure to tobacco smoke outside home	0.1	0.1	0.3	0.5	-0.5	0.3	0.3	0.1
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	-0.7	-0.1	-0.4	-0.6	-0.4
Number of children fathered	0.1	0.1	0.2	0.3	0.4	0.5	0.4	0.4
Pulse wave peak to peak time	0.1	0.1	0.3	0.6	-0.4	0.3	0.1	-0.1
Health satisfaction	0.1	0.1	0.5	0.1	-0.7	-0.0	0.3	0.1
Qualifications: College or University degree	0.1	0.2	0.5	0.3	0.7	0.3	0.4	0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	0.5	0.0	0.5	0.2	0.2
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.5	-0.1	0.3	-0.3	-0.1
Whole body fat mass	0.1	0.4	0.7	-0.8	0.8	0.1	0.4	0.8
Overall health rating	0.1	0.2	0.5	0.1	0.3	0.2	0.5	0.7
Had major operations	0.1	0.1	0.2	0.3	-0.4	0.4	0.0	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.3	-0.3	0.4	-0.0	0.0
Illnesses of siblings: Diabetes	0.1	0.1	0.4	-0.6	0.1	-0.2	0.0	0.1
Smoking status: Previous	0.1	0.2	0.4	-0.1	-0.4	-0.6	-0.1	-0.4
Friendships satisfaction	0.1	0.1	0.3	-0.0	0.3	-0.5	-0.1	-0.2
Breast cancer (self-reported)	0.1	0.1	0.5	0.7	0.2	0.4	0.0	-0.0
Arm fat mass (left)	0.1	0.3	1.1	-1.0	0.3	-0.3	-0.2	0.1
Average weekly champagne plus white wine intake	0.1	0.2	0.3	0.2	0.0	0.6	0.4	0.6
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.1	0.6	0.0	-0.3	-0.1
Medication: Paracetamol	0.1	0.1	0.3	0.5	-0.5	0.4	-0.0	-0.0
Medication: Atorvastatin	0.1	0.1	0.4	-0.6	-0.1	-0.2	0.3	0.3
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.3	0.5	-0.0	0.6	0.4	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.4	-0.1	0.2	-0.0	0.3
Pain experienced in last month	0.1	0.2	0.4	0.0	0.2	-0.2	-0.6	-0.6
Supplements: Calcium	0.1	0.1	0.3	-0.1	0.2	-0.5	-0.3	-0.3
Leg fat mass (left)	0.1	0.5	0.9	-0.5	0.8	0.3	0.7	1.0
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	0.4	-0.0	0.4	0.2	0.1
Crohns Disease (2017)	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.3	0.1
Age at First Birth	0.0	0.0	0.1	0.3	0.1	0.2	-0.2	-0.1
Schizophrenia (2014)	0.0	0.1	0.1	0.4	-0.3	0.2	-0.2	-0.2
Smoking Status	0.0	0.0	0.1	-0.1	-0.3	0.0	-0.1	-0.1
Allergy or Eczema	0.0	0.1	0.4	0.1	-0.6	-0.1	-0.2	-0.2
Hair Pigment	0.0	0.2	0.4	-0.7	-0.5	-0.5	-0.1	-0.2
Systolic blood pressure, automated reading	0.0	0.1	0.1	-0.3	0.3	-0.4	-0.2	-0.3
Body mass index (BMI)	0.0	0.1	0.3	-0.6	0.1	-0.1	-0.1	0.1
Ever unenthusiastic/disinterested for a whole week	0.0	0.1	0.1	0.4	-0.1	0.2	-0.2	-0.2
Qualifications: None of the above	0.0	0.0	0.1	-0.2	0.0	-0.2	-0.1	-0.1
Fluid intelligence score	0.0	0.0	0.1	0.1	0.2	0.0	-0.2	-0.3
Happiness	0.0	0.0	0.0	0.0	0.1	-0.0	0.1	0.2
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	0.3	0.4	0.5	-0.2	0.0
Medication: Paracetamol	0.0	0.1	0.2	-0.2	-0.5	0.0	-0.1	-0.1
Headache pain in last month	0.0	0.0	0.0	-0.0	0.1	0.0	0.0	0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.2	-0.3	-0.1	-0.4	0.1	-0.0
Comparative body size at age 10	0.0	0.1	0.3	0.1	0.0	-0.1	-0.6	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	0.1	-0.2	0.1	0.1	0.2
Shortness of breath walking on level ground	0.0	0.0	0.1	0.1	-0.3	0.2	0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.2	-0.1	0.4	-0.0	0.1	0.2
Mood swings	0.0	0.0	0.0	-0.1	-0.2	0.0	0.0	-0.0
Long-standing illness, disability or infirmity	0.0	0.0	0.1	-0.1	-0.0	-0.2	-0.2	-0.2
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.3	-0.0	-0.0	-0.2	-0.1
Medication for cholesterol	0.0	0.1	0.1	0.2	0.3	0.2	0.1	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.1	0.1	-0.2	-0.1	0.2	0.3	0.3
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.1	-0.0	-0.2	-0.3	-0.1	-0.2

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LOC283267

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Trait associations