[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) :

chr11:61,417,472-63,110,149

Best TWAS P=1.17e-09 · Best GWAS P=1.63e-08 conditioned to 0.766

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous ROM1 0.25 0.17 lasso 3 0.18 1.5e-14 5.5 -5.7 1.4e-08 -0.98 0.02 0.98 FALSE
2 GTEx Adipose Visceral Omentum ROM1 0.29 0.16 lasso 8 0.23 3.7e-12 5.5 -5.9 3.4e-09 -0.96 0.02 0.98 FALSE
3 GTEx Artery Aorta ROM1 0.18 0.17 lasso 7 0.16 3.3e-09 5.5 -5.6 2.4e-08 -0.96 0.02 0.98 FALSE
4 GTEx Artery Tibial ROM1 0.14 0.05 lasso 6 0.03 2.5e-03 5.6 -5.6 2.5e-08 -0.97 0.02 0.97 FALSE
5 GTEx Breast Mammary Tissue ROM1 0.10 0.09 lasso 5 0.06 5.4e-04 5.5 -5.5 2.8e-08 -0.96 0.02 0.98 FALSE
6 GTEx Breast Mammary Tissue (Female) ROM1 0.16 0.02 lasso 4 0.04 2.9e-02 5.5 -5.5 2.9e-08 -0.93 0.02 0.85 FALSE
7 GTEx Cells EBV-transformed lymphocytes EML3 0.33 0.22 lasso 8 0.21 1.6e-07 5.3 5.2 1.9e-07 0.94 0.02 0.98 FALSE
8 GTEx Cells Transformed fibroblasts MTA2 0.06 0.09 lasso 1 0.07 3.0e-06 5.3 5.3 9.4e-08 0.85 0.02 0.97 FALSE
9 GTEx Cells Transformed fibroblasts EML3 0.19 0.16 lasso 9 0.18 7.3e-14 5.4 5.7 1.2e-08 0.93 0.02 0.98 FALSE
10 GTEx Esophagus Mucosa MTA2 0.29 0.34 lasso 5 0.33 6.9e-23 5.6 5.6 2.5e-08 0.96 0.02 0.98 FALSE
11 GTEx Esophagus Mucosa EML3 0.40 0.43 lasso 8 0.46 1.8e-33 5.5 5.5 3.7e-08 0.97 0.02 0.98 FALSE
12 GTEx Lung ROM1 0.25 0.18 enet 13 0.20 2.2e-15 5.6 -5.8 5.8e-09 -0.97 0.02 0.98 FALSE
13 GTEx Lung EML3 0.07 0.04 lasso 3 0.01 2.5e-02 5.6 5.6 1.9e-08 0.97 0.02 0.96 FALSE
14 GTEx Nerve Tibial EML3 0.17 0.10 lasso 4 0.09 3.9e-07 5.6 5.7 1.5e-08 0.96 0.02 0.98 FALSE
15 GTEx Ovary ROM1 0.25 0.00 lasso 5 0.00 3.3e-01 5.3 -5.8 9.1e-09 -0.95 0.02 0.77 FALSE
16 GTEx Skin Not Sun Exposed Suprapubic EML3 0.20 0.19 lasso 3 0.24 2.7e-13 5.6 5.6 1.7e-08 0.96 0.02 0.98 FALSE
17 GTEx Skin Not Sun Exposed Suprapubic B3GAT3 0.18 0.11 lasso 3 0.11 9.8e-07 4.8 5.2 1.5e-07 0.80 0.08 0.91 FALSE
18 GTEx Skin Sun Exposed Lower leg ROM1 0.13 0.11 lasso 4 0.10 9.7e-09 5.6 -5.8 7.8e-09 -0.96 0.01 0.99 FALSE
19 GTEx Skin Sun Exposed Lower leg EML3 0.32 0.25 enet 19 0.26 8.0e-22 5.6 5.2 1.7e-07 0.94 0.01 0.99 FALSE
20 GTEx Spleen GANAB 0.35 -0.01 lasso 9 0.01 1.3e-01 5.6 5.3 1.3e-07 0.88 0.03 0.66 FALSE
21 GTEx Stomach EML3 0.11 0.04 enet 5 0.03 2.1e-02 5.5 5.8 7.7e-09 0.94 0.02 0.87 FALSE
22 GTEx Testis EML3 0.27 0.22 enet 15 0.29 2.7e-13 5.6 5.7 1.2e-08 0.97 0.02 0.98 FALSE
23 GTEx Thyroid ROM1 0.17 0.16 lasso 8 0.16 3.6e-12 5.6 -5.7 1.6e-08 -0.98 0.02 0.98 FALSE
24 GTEx Thyroid EML3 0.10 0.11 lasso 4 0.10 5.9e-08 5.6 5.6 1.6e-08 0.96 0.01 0.99 FALSE
25 GTEx Whole Blood EML3 0.17 0.09 lasso 7 0.08 6.3e-08 5.5 5.6 2.6e-08 0.96 0.02 0.98 FALSE
26 YFS Blood EEF1G 0.30 0.45 lasso 6 0.45 3.6e-166 5.5 -5.5 5.0e-08 -0.96 0.03 0.97 FALSE
27 YFS Blood EML3 0.20 0.31 lasso 12 0.33 1.3e-110 5.6 5.6 2.0e-08 0.98 0.01 0.99 FALSE
28 YFS Blood INTS5 0.09 0.12 lasso 4 0.12 1.9e-38 4.8 5.3 1.4e-07 0.81 0.47 0.53 FALSE
29 The Cancer Genome Atlas Bladder Urothelial Carcinoma EEF1G 0.04 0.05 lasso 1 0.04 1.1e-04 5.5 -5.5 3.2e-08 -0.98 0.01 0.97 FALSE
30 The Cancer Genome Atlas Breast Invasive Carcinoma EEF1G 0.02 0.04 lasso 2 0.03 6.3e-07 5.5 -5.5 4.4e-08 -0.96 0.02 0.98 FALSE
31 The Cancer Genome Atlas Breast Invasive Carcinoma EML3 0.02 0.02 lasso 4 0.02 2.5e-05 5.6 5.7 1.6e-08 1.00 0.01 0.99 FALSE
32 The Cancer Genome Atlas Breast Invasive Carcinoma ROM1 0.01 0.02 enet 4 0.02 2.4e-04 5.5 -5.3 1.2e-07 -0.97 0.01 0.97 FALSE
33 The Cancer Genome Atlas Colon Adenocarcinoma EEF1G 0.07 0.11 lasso 1 0.11 9.2e-07 5.3 -5.3 1.1e-07 -0.96 0.02 0.98 FALSE
34 The Cancer Genome Atlas Colon Adenocarcinoma EML3 0.07 0.03 blup 29 0.05 6.5e-04 5.3 5.8 6.6e-09 0.89 0.01 0.90 FALSE
35 The Cancer Genome Atlas Glioblastoma Multiforme RAB3IL1 0.13 0.10 lasso 2 0.09 1.2e-03 -5.3 5.2 2.1e-07 -0.01 0.01 0.82 FALSE
36 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma EEF1G 0.10 0.09 blup 26 0.09 9.8e-11 5.3 -5.2 2.6e-07 -0.87 0.02 0.98 FALSE
37 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma EEF1G 0.11 0.12 blup 27 0.13 5.5e-14 5.6 -5.5 4.1e-08 -0.95 0.02 0.98 FALSE
38 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma EML3 0.04 0.06 lasso 3 0.06 1.7e-07 5.6 5.6 1.8e-08 0.97 0.01 0.99 FALSE
39 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RAB3IL1 0.05 0.03 lasso 1 0.01 3.0e-02 -5.3 5.3 1.4e-07 -0.01 0.02 0.75 TRUE
40 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma EML3 0.06 0.09 lasso 2 0.08 1.6e-05 5.2 5.3 1.0e-07 0.89 0.03 0.96 FALSE
41 The Cancer Genome Atlas Brain Lower Grade Glioma EEF1G 0.06 0.07 blup 27 0.07 8.1e-09 5.5 -5.9 4.2e-09 -0.93 0.02 0.98 FALSE
42 The Cancer Genome Atlas Brain Lower Grade Glioma EML3 0.03 0.04 blup 28 0.03 7.6e-05 5.6 6.0 2.1e-09 0.96 0.01 0.98 FALSE
43 The Cancer Genome Atlas Brain Lower Grade Glioma RAB3IL1 0.11 0.11 lasso 4 0.10 9.7e-12 -5.2 5.2 2.2e-07 0.00 0.03 0.97 FALSE
44 The Cancer Genome Atlas Liver Hepatocellular Carcinoma EEF1G 0.06 0.03 blup 27 0.04 4.5e-03 5.2 -5.2 1.8e-07 -0.95 0.01 0.70 FALSE
45 The Cancer Genome Atlas Lung Adenocarcinoma EEF1G 0.06 0.08 lasso 8 0.08 5.9e-10 5.5 -5.6 2.1e-08 -0.94 0.02 0.98 FALSE
46 The Cancer Genome Atlas Lung Adenocarcinoma EML3 0.03 0.03 blup 28 0.03 8.4e-05 5.5 5.9 4.3e-09 0.97 0.02 0.98 FALSE
47 The Cancer Genome Atlas Lung Adenocarcinoma ROM1 0.04 0.04 blup 23 0.04 9.5e-06 5.5 -5.6 1.8e-08 -0.96 0.01 0.99 FALSE
48 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C11orf83 0.07 0.01 blup 24 0.01 1.0e-02 4.8 -5.1 2.9e-07 -0.73 0.01 0.80 FALSE
49 The Cancer Genome Atlas Lung Squamous Cell Carcinoma EEF1G 0.08 0.13 lasso 4 0.12 3.1e-13 5.5 -5.5 4.9e-08 -0.96 0.02 0.98 FALSE
50 The Cancer Genome Atlas Lung Squamous Cell Carcinoma EML3 0.04 0.05 blup 27 0.05 3.5e-06 5.5 5.9 3.1e-09 0.93 0.01 0.99 FALSE
51 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma EML3 0.03 0.02 blup 27 0.03 3.5e-03 5.5 5.5 4.2e-08 0.96 0.01 0.76 FALSE
52 The Cancer Genome Atlas Pancreatic Adenocarcinoma EEF1G 0.08 0.08 blup 27 0.05 3.6e-03 5.5 -5.9 4.2e-09 -0.95 0.02 0.94 FALSE
53 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma EEF1G 0.08 0.00 blup 27 0.04 1.3e-02 5.5 -6.0 1.8e-09 -0.91 0.01 0.83 FALSE
54 The Cancer Genome Atlas Prostate Adenocarcinoma EEF1G 0.08 0.13 lasso 2 0.12 1.8e-12 5.5 -5.5 4.3e-08 -0.96 0.02 0.98 FALSE
55 The Cancer Genome Atlas Prostate Adenocarcinoma EML3 0.09 0.14 lasso 1 0.14 3.4e-14 5.5 5.5 3.2e-08 0.98 0.01 0.99 FALSE
56 The Cancer Genome Atlas Rectum Adenocarcinoma EML3 0.36 0.08 blup 27 0.19 3.7e-05 5.6 5.8 7.2e-09 0.82 0.01 0.82 FALSE
57 The Cancer Genome Atlas Soft Tissue Sarcoma ROM1 0.06 0.05 blup 24 0.03 8.1e-03 5.5 -5.5 3.4e-08 -0.97 0.01 0.87 FALSE
58 The Cancer Genome Atlas Stomach Adenocarcinoma EEF1G 0.05 0.07 blup 27 0.07 1.7e-05 5.3 -5.9 2.9e-09 -0.96 0.02 0.98 FALSE
59 The Cancer Genome Atlas Stomach Adenocarcinoma ROM1 0.05 0.08 lasso 3 0.08 3.1e-06 5.6 -5.7 1.0e-08 -0.96 0.01 0.99 FALSE
60 The Cancer Genome Atlas Thyroid Carcinoma EEF1G 0.15 0.27 blup 27 0.28 3.6e-27 5.6 -5.2 1.7e-07 -0.91 0.01 0.99 FALSE
61 The Cancer Genome Atlas Thyroid Carcinoma EML3 0.11 0.10 blup 28 0.12 2.3e-11 5.5 6.1 1.2e-09 0.92 0.03 0.97 TRUE
62 The Cancer Genome Atlas Thyroid Carcinoma ROM1 0.03 0.02 blup 23 0.02 1.1e-02 5.6 -5.3 1.2e-07 -0.96 0.01 0.92 FALSE