[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) : ← →

chr11:65,089,128-69,476,279

Best TWAS P=3.13e-26 · Best GWAS P=5.52e-24 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Esophagus Muscularis	RAD9A	0.25	0.26	lasso	2	0.26	6.2e-16	-10.1	-10.6	3.1e-26	0.99	0.00	1.00	TRUE
31	ROSMAP	Brain Pre-frontal Cortex	RAD9A	0.34	0.17	enet	21	0.20	1.1e-25	-10.1	-9.3	8.6e-21	0.89	0.00	1.00	TRUE
24	GTEx	Thyroid	RAD9A	0.27	0.07	lasso	6	0.20	1.8e-15	-10.1	-7.2	8.5e-13	0.70	0.00	1.00	TRUE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC87	0.03	0.02	blup	34	0.02	2.0e-03	5.8	6.9	4.0e-12	-0.13	0.01	0.81	TRUE
14	GTEx	Esophagus Muscularis	IGHMBP2	0.12	0.06	enet	17	0.06	9.4e-05	4.3	6.3	3.7e-10	0.05	0.60	0.31	TRUE
26	METSIM	Adipose	CTD-3074O7.12	0.12	0.12	bslmm	265	0.12	4.2e-18	5.1	-5.8	7.7e-09	0.24	0.35	0.65	TRUE
7	GTEx	Brain Cerebellar Hemisphere	ZDHHC24	0.22	0.11	enet	15	0.16	8.2e-05	5.2	-5.7	9.7e-09	0.08	0.06	0.70	TRUE
6	GTEx	Artery Tibial	CTD-3074O7.12	0.08	0.01	enet	15	0.03	2.6e-03	-3.3	-5.7	1.4e-08	0.23	0.11	0.85	TRUE
30	ROSMAP	Brain Pre-frontal Cortex	PPP6R3	0.04	0.01	blup	421	0.02	3.2e-04	-4.7	5.3	1.1e-07	-0.03	0.22	0.76	TRUE
19	GTEx	Nerve Tibial	CTD-3074O7.12	0.14	0.10	lasso	8	0.11	5.6e-08	5.2	-5.3	1.3e-07	0.17	0.29	0.70	TRUE
43	The Cancer Genome Atlas	Thyroid Carcinoma	PELI3	0.04	0.04	enet	4	0.03	9.0e-04	5.2	-5.2	1.8e-07	0.12	0.01	0.90	TRUE
4	GTEx	Artery Tibial	RAD9A	0.39	0.26	lasso	2	0.24	3.5e-19	-10.1	-10.1	5.5e-24	1.00	0.00	1.00	FALSE
22	GTEx	Testis	RAD9A	0.72	0.50	lasso	4	0.49	1.1e-24	-10.1	-10.0	1.2e-23	1.00	0.00	1.00	FALSE
1	GTEx	Adipose Subcutaneous	RAD9A	0.43	0.22	lasso	6	0.23	7.1e-19	-10.1	-9.8	1.9e-22	0.97	0.00	1.00	FALSE
18	GTEx	Nerve Tibial	RAD9A	0.53	0.24	lasso	10	0.23	5.6e-16	-10.1	-9.7	4.8e-22	0.99	0.00	1.00	FALSE
10	GTEx	Cells Transformed fibroblasts	RAD9A	0.24	0.16	lasso	3	0.16	3.6e-12	-10.1	-9.0	1.8e-19	0.92	0.00	1.00	FALSE
12	GTEx	Colon Transverse	RAD9A	0.40	0.16	lasso	8	0.16	7.2e-08	-10.1	-8.6	6.8e-18	0.88	0.00	1.00	FALSE
17	GTEx	Muscle Skeletal	RAD9A	0.12	0.02	lasso	4	0.03	4.2e-04	-10.1	-7.8	9.0e-15	0.83	0.00	0.99	FALSE
34	YFS	Blood	RAD9A	0.08	0.02	lasso	7	0.04	5.4e-12	-10.1	-7.3	2.4e-13	0.78	0.00	1.00	FALSE
16	GTEx	Esophagus Muscularis	MRGPRF	0.09	0.01	lasso	3	0.01	1.3e-01	-5.3	6.0	1.5e-09	0.02	0.02	0.81	FALSE
33	YFS	Blood	CATSPER1	0.02	0.01	blup	352	0.01	5.5e-04	-4.6	5.8	5.5e-09	-0.21	0.03	0.95	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SAPS3	0.04	0.02	blup	84	0.04	2.5e-05	-4.4	5.8	6.0e-09	0.00	0.19	0.80	FALSE
27	METSIM	Adipose	MTL5	0.07	0.04	bslmm	420	0.04	2.7e-06	4.4	5.8	7.6e-09	0.01	0.99	0.00	FALSE
20	GTEx	Pancreas	DPP3	0.19	0.13	lasso	8	0.14	1.4e-06	4.9	-5.7	9.3e-09	0.15	0.31	0.68	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	CCS	0.08	0.04	lasso	9	0.06	8.9e-08	5.5	-5.7	9.4e-09	0.20	0.07	0.93	FALSE
8	GTEx	Breast Mammary Tissue	DPP3	0.14	0.07	lasso	2	0.05	1.5e-03	4.9	-5.7	1.0e-08	0.11	0.04	0.94	FALSE
28	NTR	Blood	CCS	0.03	0.04	lasso	2	0.04	1.2e-11	5.5	-5.7	1.5e-08	0.23	0.05	0.95	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	CTSF	0.05	0.04	blup	35	0.04	1.2e-05	5.2	5.6	1.9e-08	-0.16	0.03	0.96	FALSE
29	NTR	Blood	MRPL21	0.06	0.07	enet	19	0.07	7.0e-23	4.5	-5.6	2.4e-08	-0.03	1.00	0.00	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	CCS	0.21	0.24	enet	11	0.21	2.0e-07	5.5	-5.5	3.9e-08	0.22	0.06	0.94	FALSE
36	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	DPP3	0.05	0.02	blup	41	0.02	2.8e-02	4.9	-5.4	6.0e-08	0.15	0.02	0.68	FALSE
13	GTEx	Esophagus Muscularis	TCIRG1	0.10	0.09	lasso	2	0.06	8.7e-05	-3.7	5.4	7.5e-08	-0.43	0.20	0.07	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZDHHC24	0.03	0.03	blup	47	0.03	1.5e-04	5.2	5.3	9.2e-08	-0.20	0.05	0.92	FALSE
2	GTEx	Adipose Subcutaneous	DPP3	0.08	0.06	lasso	9	0.06	2.1e-05	4.9	-5.3	9.5e-08	0.14	0.31	0.69	FALSE
5	GTEx	Artery Tibial	DPP3	0.07	0.04	lasso	3	0.03	3.2e-03	5.2	-5.3	1.3e-07	0.13	0.22	0.73	FALSE
23	GTEx	Testis	CTD-3074O7.5	0.22	0.16	enet	16	0.19	8.0e-09	5.2	5.3	1.4e-07	-0.18	0.32	0.68	FALSE
25	GTEx	Vagina	CTD-3074O7.5	0.17	0.16	lasso	5	0.11	1.7e-03	5.2	-5.3	1.4e-07	0.14	0.10	0.55	FALSE
11	GTEx	Cells Transformed fibroblasts	CTD-3074O7.12	0.19	0.00	enet	20	0.03	3.5e-03	-3.3	-5.2	1.7e-07	0.14	0.03	0.88	FALSE
35	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DPP3	0.03	0.03	blup	41	0.02	9.5e-03	5.2	-5.2	1.8e-07	0.10	0.04	0.71	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	ZDHHC24	0.03	0.04	lasso	1	0.04	6.4e-06	5.2	5.2	1.8e-07	-0.13	0.07	0.92	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	DPP3	0.08	0.09	lasso	1	0.08	2.3e-05	5.2	-5.2	2.0e-07	0.13	0.27	0.64	FALSE
3	GTEx	Artery Aorta	ZDHHC24	0.09	0.09	lasso	2	0.06	2.0e-04	5.2	5.2	2.3e-07	-0.14	0.30	0.57	FALSE
40	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DPP3	0.05	0.07	lasso	5	0.06	1.4e-04	5.2	-5.2	2.4e-07	0.13	0.05	0.81	FALSE