Best TWAS P=4.74e-11 · Best GWAS P=1.05e-08 conditioned to 0.621
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RELT | 0.06 | 0.02 | blup | 318 | 0.04 | 4.1e-06 | 4.8 | 5.7 | 1.5e-08 | 0.71 | 0.06 | 0.91 | FALSE |
| 2 | GTEx | Spleen | RP11-809N8.4 | 0.33 | 0.03 | lasso | 4 | 0.03 | 5.5e-02 | 4.4 | 5.2 | 1.6e-07 | 0.77 | 0.02 | 0.58 | FALSE |
| 3 | GTEx | Whole Blood | ARHGEF17 | 0.15 | 0.16 | lasso | 3 | 0.16 | 8.6e-15 | 5.4 | 5.6 | 2.0e-08 | 0.97 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Whole Blood | RP11-809N8.4 | 0.08 | 0.06 | lasso | 2 | 0.04 | 6.5e-05 | 5.2 | 5.4 | 7.7e-08 | 0.70 | 0.06 | 0.93 | FALSE |
| 5 | GTEx | Whole Blood | RP11-800A3.7 | 0.19 | 0.11 | enet | 10 | 0.12 | 2.0e-11 | 5.4 | 5.7 | 1.1e-08 | 0.85 | 0.01 | 0.99 | FALSE |
| 6 | NTR | Blood | RELT | 0.04 | 0.05 | lasso | 5 | 0.04 | 1.8e-13 | 5.3 | 5.6 | 2.4e-08 | 0.66 | 0.04 | 0.96 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | FAM168A | 0.03 | 0.02 | bslmm | 358 | 0.02 | 2.6e-03 | 4.9 | -6.6 | 4.7e-11 | -0.83 | 0.07 | 0.88 | TRUE |
| 8 | YFS | Blood | ARHGEF17 | 0.09 | 0.17 | lasso | 5 | 0.17 | 1.4e-53 | 5.7 | 5.6 | 1.9e-08 | 0.99 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RELT | 0.06 | 0.07 | blup | 35 | 0.08 | 3.5e-09 | 5.3 | 5.4 | 6.6e-08 | 0.78 | 0.02 | 0.98 | FALSE |
| 10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ARHGEF17 | 0.04 | 0.03 | blup | 54 | 0.02 | 1.2e-02 | 5.5 | 5.7 | 1.2e-08 | 0.91 | 0.01 | 0.78 | FALSE |