TWAS hub - RELT

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0630	0.0220	7.0e-05	0.023	0.044	0.010	0.042	0.016	7.0e-04	4.1e-06	1.8e-02	6.0e-06	4.6e-03
2	NTR	Blood	0.0386	0.0117	2.5e-11	0.047	0.039	0.040	0.039	0.042	7.7e-15	9.6e-13	4.8e-13	1.2e-12	1.8e-13
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0597	0.0271	1.9e-08	0.072	0.079	0.064	NA	0.067	1.5e-08	3.5e-09	1.1e-07	NA	4.8e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Lung FEV1/FVC ratio	11.0	55.6	68.9	6.9	7.1	8.3
Forced expiratory volume in 1-second (FEV1)	9.1	30.8	32.1	5.7	5.6	5.4
Pain all over the body in last month	9.0	9.6	10.9	3.1	2.9	3.3
Forced expiratory volume in 1-second (FEV1), Best measure	8.8	28.2	31.9	5.1	5.7	5.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	8.5	17.9	18.0	4.2	4.2	4.2
High blood pressure (siblings)	7.6	10.9	12.0	-3.1	-3.3	-3.5
Hearing difficulty/problems with background noise	7.3	11.7	14.6	-3.8	-3.4	-3.0
Peak expiratory flow (PEF)	7.1	16.4	22.2	4.7	3.8	3.5
Illnesses of siblings	6.5	9.1	12.4	2.1	3.2	3.5
Illnesses of father: High blood pressure	6.3	7.8	13.2	-1.9	-2.5	-3.6
Medication: Atenolol	5.2	6.4	7.2	-2.3	-2.7	-2.7
Diastolic blood pressure, automated reading	5.1	15.8	20.3	-3.1	-4.2	-4.5
Major Depression (MDD)	4.7	5.7	7.0	2.3	2.6	2.2
Pulse wave Arterial Stiffness index	4.5	5.3	7.6	-2.8	-2.2	-1.8
Pulse wave peak to peak time	4.5	5.3	7.9	2.8	2.2	1.8
Illnesses of mother	3.8	4.7	6.9	1.4	2.3	2.6
Average weekly champagne plus white wine intake	3.8	5.2	7.6	2.1	2.8	1.9
Forced vital capacity (FVC)	3.6	13.7	15.3	3.9	3.8	3.3
Schizophrenia (2018)	3.5	7.2	8.4	2.3	2.8	2.9
Medication: Ramipril	3.5	4.5	6.0	-1.2	-2.5	-2.5
Exposure to tobacco smoke outside home	3.4	4.6	8.1	-2.8	-2.0	-1.3
Hair/balding pattern: Pattern 2	3.3	4.2	7.3	0.4	-2.3	-2.7
Bipolar Disorder or Schizophrenia	3.2	7.7	9.2	2.4	3.0	2.9
Forced vital capacity (FVC), Best measure	3.2	11.8	14.5	3.5	3.8	3.0
Qualifications: NVQ or HND or HNC or equivalent	3.2	3.9	4.1	-2.0	-2.0	-1.9
Ever taken oral contraceptive pill	3.1	3.4	5.3	1.4	1.7	2.3
High blood pressure (mother)	2.9	4.1	5.4	-1.3	-2.3	-2.3
Hand grip strength (left)	2.7	7.1	13.1	-1.6	-2.4	-3.6
Sensitivity / hurt feelings	2.7	4.7	6.5	1.7	2.2	2.5
Medication: Simvastatin	2.7	4.0	5.8	-2.4	-2.0	-1.5
Birth weight of first child	2.7	4.9	11.0	3.3	1.5	1.3
Heart disease (mother)	2.7	3.3	4.6	-1.4	-1.8	-2.1
Lung FVC	2.6	13.1	14.7	3.5	3.8	3.5
Maternal smoking around birth	2.6	3.7	5.1	1.7	1.8	2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	3.2	-1.7	-1.6	-1.8
Falls in the last year	2.4	3.3	4.8	1.0	2.2	2.0
Qualifications: A levels/AS levels or equivalent	2.4	5.3	8.8	1.4	3.0	2.3
Supplements: Zinc	2.3	2.5	3.5	1.9	1.8	1.0
Time employed in main current job	2.3	2.7	4.4	-0.6	-1.8	-2.1
Medication for cholesterol, blood pressure or diabetes	2.3	3.9	7.6	2.7	1.5	1.4
Medication: Amlodipine	2.3	3.3	4.2	-1.3	-2.0	-2.1
Medication: Blood pressure	2.3	4.4	6.5	-1.2	-2.5	-2.3
Primary Biliary Cirrhosis	2.2	3.1	5.3	-2.3	-1.7	-1.0
Chronic bronchitis/emphysema (father)	2.2	2.6	4.5	-1.2	-1.4	-2.1
Coronary Artery Disease (CAD)	2.1	2.5	3.2	1.7	1.8	1.3
Relative age of first facial hair	2.1	4.4	5.8	1.9	2.4	1.9
Hand grip strength (right)	2.1	5.6	10.2	-1.1	-2.3	-3.2
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.6	4.1	0.4	2.0	1.9
Average weekly beer plus cider intake	2.1	3.0	3.7	-1.4	-1.9	-1.9
Pain experienced in last month	2.1	3.5	4.5	-1.9	-1.6	-2.1
Heart disease (siblings)	2.1	2.6	4.6	0.5	-2.2	-1.7
Breast Cancer	2.0	4.9	7.7	0.9	-2.8	-2.5
Age at First Birth	2.0	2.9	6.1	0.8	2.5	1.4
Systolic blood pressure, automated reading	2.0	5.9	8.3	-1.8	-2.9	-2.5
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	3.2	-1.8	-1.7	-1.1
Ever had bowel cancer screening	2.0	2.3	2.7	1.6	1.3	1.6
Body Mass Index (BMI) (2010)	1.9	2.6	2.9	-1.5	-1.7	-1.6
Lupus	1.9	2.9	4.0	1.8	1.1	2.0
Hypertension (Self-reported)	1.9	5.4	5.6	-2.4	-2.2	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	2.6	-1.6	-1.0	-1.6
Vascular/heart problems diagnosed by doctor	1.9	5.3	5.8	2.4	2.3	2.2
Noisy workplace	1.8	2.2	3.7	-0.5	-1.9	-1.6
Mouth/teeth dental problems: Loose teeth	1.8	2.1	4.6	-2.1	-1.1	-0.7
Alcohol intake frequency.	1.8	4.1	6.2	-2.5	-1.9	-1.7
Arm fat mass (left)	1.8	7.2	9.1	-1.9	-3.0	-3.0
Neuroticism (2016)	1.7	2.5	4.7	0.6	1.6	2.2
Schizophrenia (2014)	1.7	3.7	5.3	1.3	2.0	2.3
Relative age voice broke	1.7	2.5	3.1	1.8	1.7	1.3
Arm fat percentage (right)	1.7	6.6	10.0	-1.4	-3.2	-2.8
Ever highly irritable/argumentative for 2 days	1.7	2.1	2.9	-1.0	-1.5	-1.7
Qualifications: College or University degree	1.7	5.4	9.8	1.7	3.1	1.8
Pulse rate, automated reading	1.7	5.4	14.3	-3.8	-1.1	-0.7
Hearing aid user	1.7	2.0	3.4	1.8	0.9	1.3
Risk taking	1.7	2.5	4.0	-1.1	-1.5	-2.0
BMI	1.6	9.6	11.0	-2.8	-3.3	-3.2
Hearing difficulty/problems: Yes	1.6	2.5	4.1	-1.3	-2.0	-1.3
High blood pressure	1.6	4.6	5.1	-2.2	-2.0	-2.1
Alcohol usually taken with meals	1.6	2.7	4.3	0.2	2.1	1.9
Arm fat mass (right)	1.6	6.7	8.9	-1.7	-3.0	-2.9
Medication: Blood pressure	1.6	2.8	5.4	-2.3	-1.2	-1.3
Supplements: Vitamin C	1.6	1.9	2.3	1.1	1.5	1.5
Vitamin and mineral supplements	1.5	2.1	4.0	-2.0	-1.1	-1.0
Trunk fat percentage	1.5	6.0	7.8	-1.9	-2.8	-2.6
Body mass index (BMI)	1.5	6.2	8.5	-1.6	-2.9	-2.8
Arm fat percentage (left)	1.5	6.1	8.8	-1.6	-3.0	-2.7
Breast cancer (self-reported)	1.5	1.8	3.0	-0.7	-1.7	-1.4
Cardiovascular Disease	1.4	4.7	6.7	-1.9	-2.0	-2.6
Medication for hormone replacement therapy	1.4	1.6	2.4	0.9	1.3	1.5
Multivitamins +/- minerals	1.4	1.8	2.5	1.6	1.2	1.2
Trunk fat mass	1.4	5.9	7.8	-1.6	-2.8	-2.7
Wheeze or whistling in the chest in last year	1.4	2.5	4.0	-1.1	-2.0	-1.5
Fluid intelligence score	1.3	2.7	3.6	-1.2	1.9	1.7
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.6	1.6	1.2	0.8
Pulse wave reflection index	1.3	1.7	2.8	-0.3	-1.7	-1.5
Number of children fathered	1.3	1.5	2.5	1.6	1.3	0.6
Medication: Ibuprofen	1.3	1.6	2.5	0.4	1.6	1.4
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	2.6	1.3	1.6	1.3
High cholesterol (Self-reported)	1.3	2.3	4.4	-2.1	-1.4	-0.9
Depression (Nagel 2018)	1.2	1.8	4.0	2.0	0.9	0.8
Fasting Glucose	1.2	1.4	2.3	-0.0	-1.5	-1.3
Number of treatments/medications taken	1.2	2.1	2.7	-1.4	-1.6	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	4.4	-1.2	-1.5	-2.1
Qualifications: None of the above	1.2	2.6	5.4	-0.1	-2.3	-1.5
Number of live births	1.2	1.7	2.7	0.4	1.6	1.5
Pulse rate	1.2	2.1	6.1	-2.5	-0.2	-0.2
Qualifications: O levels/GCSEs or equivalent	1.2	1.8	2.9	1.1	1.7	1.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.1	-1.5	-1.0	-1.0
Body fat percentage	1.2	4.9	6.9	-1.4	-2.6	-2.4
Shortness of breath walking on level ground	1.2	1.4	2.4	-1.6	-1.2	-0.6
Whole body fat mass	1.2	5.1	6.8	-1.5	-2.6	-2.5
Illnesses of siblings: Diabetes	1.2	1.5	2.3	-0.4	-1.5	-1.4
Commuting to job workplace: Walk	1.2	1.3	1.7	-1.3	-1.0	-1.0
Number of self-reported non-cancer illnesses	1.2	2.1	2.4	-1.4	-1.6	-1.3
Number of operations (self-reported)	1.2	1.8	2.6	1.0	1.6	1.3
Cholesterol lowering medication	1.2	1.8	3.3	-1.8	-1.1	-1.0
Depressed Affect (Nagel 2018)	1.1	2.3	2.8	1.6	1.2	1.7
Ulcerative Colitis	1.1	1.6	4.4	-2.1	-0.6	0.4
Impedance of leg (right)	1.1	5.3	7.0	1.5	2.6	2.5
Townsend deprivation index at recruitment	1.1	1.6	2.4	-1.6	-1.1	-1.0
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.1	-0.5	-1.3	-1.4
Serious illness, injury or assault to yourself	1.1	1.3	1.6	-1.0	-1.3	-1.1
Waist circumference	1.1	3.8	5.3	-1.5	-2.3	-2.0
Weight	1.1	5.3	7.4	-1.3	-2.6	-2.7
Medication: Cholesterol lowering	1.1	1.7	3.0	-1.7	-1.2	-0.9
Health satisfaction	1.1	1.4	3.4	-0.1	0.9	1.8
Medication for cholesterol	1.1	1.6	2.4	0.7	1.6	1.4
Basal cell carcinoma (self-reported)	1.1	1.4	1.8	1.4	1.1	1.0
Neuroticism (Nagel 2018)	1.0	2.4	4.0	1.2	1.4	2.0
Type 2 Diabetes (T2D) (2012)	1.0	1.2	1.8	-1.4	-0.9	-1.0
Blood Platelet Count	1.0	11.8	18.3	1.5	3.9	4.3
Systolic Blood Pressure	1.0	4.8	7.5	-1.6	-2.1	-2.7
Supplements: Glucosamine	1.0	1.3	2.1	1.1	1.5	0.8
Happiness	1.0	1.2	2.3	-1.5	-1.0	-0.4
Lung cancer (father)	1.0	1.1	1.9	0.8	0.9	1.4
Medication: Seretide 50 evohaler	1.0	1.1	2.1	-1.4	-0.5	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.0	1.4	0.8	0.9
Back pain experienced in last month	1.0	1.5	3.0	0.2	-1.7	-1.2
Medication: Paracetamol	1.0	1.5	4.3	2.1	-0.5	-0.2
Leg fat mass (left)	1.0	3.8	5.3	-1.2	-2.1	-2.3
Bipolar Disorder (2018)	0.9	1.5	2.3	1.1	1.5	1.0
Schizophrenia vs Biploar Disorder	0.9	1.2	2.0	1.4	0.8	1.0
Verbal and Numeric Reasoning (VNR)	0.9	2.2	2.8	-1.1	1.6	1.7
LDL Cholesterol	0.9	1.4	2.9	0.6	1.7	1.0
Blood Eosinophil Count	0.9	6.9	10.6	1.7	2.7	3.3
Blood White Count	0.9	6.6	8.4	1.8	2.9	2.9
Diabetes (father)	0.9	1.1	1.5	1.2	1.0	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.1	0.2	-1.2	-1.4
Impedance of leg (left)	0.9	4.5	6.7	1.3	2.6	2.3
Comparative body size at age 10	0.9	2.5	5.2	-0.3	-1.5	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.4	0.8	1.2	1.0
Mean time to correctly identify matches	0.9	1.7	2.8	-0.2	-1.5	-1.7
Eye problems/disorders: Glaucoma	0.9	1.1	1.8	-0.4	1.3	1.1
Ever depressed for a whole week	0.9	1.1	2.7	-1.6	-0.8	-0.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.2	1.1	0.7	0.9
Father’s age at death	0.8	1.1	1.6	-0.0	1.3	1.2
Mouth/teeth dental problems: Dentures	0.8	1.3	2.9	0.6	-1.7	-0.9
Medication: Paracetamol	0.8	1.3	3.7	1.9	-0.4	0.0
Glaucoma (self-reported)	0.8	0.9	1.3	-0.5	1.1	1.1
Emphysema/chronic bronchitis	0.8	0.9	1.2	-0.9	-1.1	-0.8
Leg fat mass (right)	0.8	3.3	4.6	-0.9	-2.1	-2.1
Leg pain on walking	0.8	1.0	3.1	-1.8	-0.2	-0.1
Medication: Aspirin	0.8	1.0	1.3	-0.9	-0.9	-1.1
Leg fat-free mass (right)	0.8	4.0	5.9	-1.3	-2.1	-2.4
Medication: Bendroflumethiazide	0.8	1.2	2.0	-0.3	-1.4	-1.3
Irritable Bowel Disease (IBD)	0.7	1.7	3.6	-1.9	-1.1	-0.4
Crohns Disease (2012)	0.7	1.2	1.9	-1.4	-1.0	-0.8
HDL Cholesterol	0.7	1.1	1.4	1.0	1.0	1.2
Neuroticism	0.7	1.7	3.0	0.2	1.4	1.7
Leg fat-free mass (left)	0.7	3.7	5.3	-1.2	-2.1	-2.3
Fed-up feelings	0.7	1.3	2.7	1.6	0.9	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.7	-0.9	-1.1	-1.6
Leg predicted mass (left)	0.7	3.8	5.5	-1.2	-2.1	-2.3
Hip circumference	0.7	2.9	4.2	-0.7	-2.0	-2.0
Headache pain in last month	0.7	1.3	1.6	1.3	1.0	1.1
Gout (self-reported)	0.7	0.9	1.9	-0.6	-1.4	-0.7
Knee pain experienced in last month	0.7	1.1	1.7	0.2	1.3	1.2
Medication: Aspirin	0.7	0.9	1.2	-0.7	-0.9	-1.1
Leg predicted mass (right)	0.7	3.8	5.5	-1.2	-2.1	-2.3
Crohns Disease (2017)	0.6	1.3	1.7	-1.1	-1.3	-0.9
Ovarian Cancer	0.6	0.8	1.5	1.2	0.8	0.5
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.8	-0.3	-1.2	-1.3
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.9	1.4	0.5	0.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.0	-0.8	0.6	1.0
Stomach or abdominal pain in last month	0.6	0.7	1.7	1.3	0.5	0.4
Medication: Levothyroxine sodium	0.6	0.9	1.6	-0.7	-1.3	-0.9
Exposure to tobacco smoke at home	0.6	0.6	1.3	-0.4	-1.1	-0.7
Breastfed as a baby	0.6	0.7	1.3	0.3	1.1	0.8
Age at first live birth	0.6	1.1	1.9	1.4	1.1	0.3
Medication: Allopurinol	0.6	0.9	1.2	-0.6	-1.1	-1.0
Comparative height size at age 10	0.6	3.3	3.7	-1.9	-1.9	-1.6
Family relationship satisfaction	0.6	0.7	1.2	0.7	0.7	1.1
Mood swings	0.6	1.0	2.1	0.8	0.6	1.5
Osteoporosis (self-reported)	0.6	0.7	2.1	1.4	0.2	0.1
Illnesses of father: None of the above (group 1)	0.6	0.7	1.7	0.1	0.7	1.3
Leg fat percentage (left)	0.6	2.3	3.2	-0.8	-1.8	-1.8
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.8	-1.4	-0.5	-0.3
Bipolar Disorder (2011)	0.5	0.5	0.9	0.3	-0.6	-0.9
Heel T-Score	0.5	3.8	7.5	-2.7	-0.6	-1.9
Respiratory disease	0.5	1.0	1.8	-1.3	-0.9	-0.7
Birth weight	0.5	1.0	1.2	0.9	1.1	1.1
Leg fat percentage (right)	0.5	1.9	3.0	-0.6	-1.7	-1.5
Neck or shoulder pain in last month	0.5	0.7	1.2	0.8	0.5	1.1
Mineral and other dietary supplements	0.5	0.6	1.3	-1.1	-0.6	-0.4
Guilty feelings	0.5	0.7	1.5	-1.2	-0.8	-0.2
Ulcerative Colitis (UC)	0.4	0.7	1.7	-1.3	-0.0	0.6
Waist Hip Ratio (WHR)	0.4	1.8	3.3	0.4	1.4	1.8
Hair Pigment	0.4	12.0	14.7	3.8	3.3	3.2
Ever had hysterectomy (womb removed)	0.4	0.5	0.8	0.9	-0.6	-0.4
Diabetes (mother)	0.4	0.6	1.3	1.1	0.4	0.5
Pack years adult smoking proportion	0.4	0.5	0.8	-0.9	-0.7	-0.6
Current tobacco smoking	0.4	0.7	1.5	1.2	0.5	0.6
Qualifications: CSEs or equivalent	0.4	0.5	0.9	-1.0	-0.7	0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.9	1.0	0.1	0.8
Worrier / anxious feelings	0.4	0.8	1.3	-1.1	0.2	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.3	0.7	0.5	1.2
Blood clot in the leg (DVT)	0.4	0.6	0.9	0.9	0.6	0.7
Overall health rating	0.4	0.8	2.3	0.3	0.1	1.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.8	0.2	0.9	0.8
Average weekly red wine intake	0.4	0.6	0.9	-0.6	-0.7	-1.0
Qualifications: nursing, teaching	0.4	0.6	0.9	-0.9	1.0	0.0
Miserableness	0.4	0.7	1.0	1.0	0.6	0.8
Medication: Lisinopril	0.4	0.5	0.8	-0.9	-0.6	-0.6
Medication: Atorvastatin	0.4	0.5	0.8	-0.9	0.6	0.5
Basal metabolic rate	0.4	2.3	3.7	-0.7	-1.7	-1.9
Alcohol drinker status: Previous	0.4	0.4	0.5	-0.7	-0.6	-0.7
Impedance of whole body	0.4	2.1	3.0	0.8	1.7	1.6
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.4	-1.6	0.6	0.5
Alzheimer’s Disease (in father)	0.3	0.4	0.6	0.7	0.7	0.1
Chronotype (morning person)	0.3	0.7	1.0	-0.7	-1.0	-0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	-0.3	0.8	0.8
Medication: Metformin	0.3	0.4	0.6	0.2	-0.8	-0.6
Severe depression (siblings)	0.3	0.3	0.5	-0.6	-0.1	-0.7
Past tobacco smoking	0.3	0.5	1.2	1.1	0.7	0.0
Had other major operations	0.3	0.4	0.7	0.2	-0.7	-0.8
Heart attack	0.3	0.4	1.0	-1.0	-0.3	-0.1
Hair/balding pattern: Pattern 3	0.3	0.5	0.8	-0.8	0.1	0.9
Hair/balding pattern: Pattern 4	0.3	0.7	1.0	-1.0	0.9	0.5
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	-0.3	0.8	0.7
Medication: Omeprazole	0.3	0.3	1.0	-1.0	-0.2	-0.1
Number of full sisters	0.3	0.3	0.7	-0.4	0.8	0.5
Had major operations	0.3	0.4	1.1	-1.0	0.2	0.1
Smoking status: Previous	0.3	0.4	1.0	-0.4	-1.0	-0.1
Whole body fat-free mass	0.3	1.4	2.5	-0.3	-1.3	-1.6
Loneliness, isolation	0.3	0.3	1.0	-1.0	-0.3	-0.1
Long-standing illness, disability or infirmity	0.3	0.5	1.2	-1.1	-0.4	-0.2
Friendships satisfaction	0.3	0.3	0.6	-0.2	-0.8	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.6	-0.0	-0.8	-0.6
Osteoarthritis (self-reported)	0.3	0.3	0.5	0.4	0.6	0.7
Wears glasses or contact lenses	0.3	0.3	0.6	-0.4	-0.8	0.5
Ever smoked	0.3	0.5	1.5	-1.2	-0.3	0.2
Arm fat-free mass (left)	0.3	1.3	2.3	-0.3	-1.2	-1.5
Irritability	0.3	0.5	1.3	-0.2	-1.1	-0.3
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.0	1.0	0.2	-0.1
Commuting to job workplace: Cycle	0.3	0.3	0.9	0.9	0.2	-0.3
Myopia	0.3	0.5	1.0	-0.6	-1.0	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.7	-0.9	0.3	0.4
Pack years of smoking	0.3	0.5	0.6	-0.8	-0.8	-0.5
Arm predicted mass (left)	0.3	1.4	2.4	-0.5	-1.2	-1.6
Worry (Nagel 2018)	0.2	0.4	1.0	0.2	0.5	1.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.3	-0.5	0.5	-0.4
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.3	0.1	-0.9
Reaction Time	0.2	0.4	0.7	0.4	-0.5	-0.8
Prostate Cancer	0.2	0.3	0.4	-0.5	0.5	0.6
Mean Putamen Volume	0.2	0.2	0.4	0.0	-0.5	-0.6
Triglycerides	0.2	0.3	0.6	0.1	-0.3	-0.8
Average weekly spirits intake	0.2	0.3	0.6	0.8	-0.3	0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.6	0.1	-0.2	0.8
Medication: Co-codamol	0.2	0.2	0.3	-0.5	-0.6	-0.4
Number of incorrect matches in round	0.2	0.3	0.4	0.6	0.3	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	-0.5	-0.8	-0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	-0.9	0.2	0.4
Alcohol intake versus 10 years previously	0.2	0.3	0.9	-0.9	-0.2	-0.3
Asthma	0.2	0.5	1.1	-1.1	-0.6	-0.0
Medication: Lansoprazole	0.2	0.2	0.4	-0.1	-0.6	-0.5
Prospective memory result	0.2	0.3	0.4	-0.5	0.5	0.6
Impedance of arm (left)	0.2	0.7	1.4	0.1	0.9	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.4	-0.6	0.5	0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.7	-0.1	-0.2	-0.8
Arm fat-free mass (right)	0.2	0.8	1.5	-0.6	-0.7	-1.2
Eye problems/disorders: None of the above	0.2	0.2	0.5	0.4	-0.1	-0.7
Arm predicted mass (right)	0.2	0.8	1.6	-0.3	-0.8	-1.2
Chest pain or discomfort	0.2	0.2	0.4	0.6	0.4	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.7	-0.6	-0.3	-0.9
Eye problems/disorders: Cataract	0.2	0.2	0.4	0.7	-0.2	0.4
Smoking status: Current	0.2	0.3	0.5	0.7	0.4	0.4
Whole body water mass	0.2	1.2	2.1	-0.2	-1.2	-1.5
Financial situation satisfaction	0.2	0.2	0.4	0.3	-0.3	-0.7
Fractured/broken bones in last 5 years	0.2	0.3	0.7	-0.3	-0.8	-0.3
Age started oral contraceptive pill	0.2	0.2	0.5	0.1	-0.4	-0.7
Unable to work because of sickness or disability	0.2	0.2	0.3	-0.4	-0.5	0.5
Supplements: Calcium	0.2	0.2	0.5	-0.3	-0.3	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.3	0.5	0.4	0.5
Blood Red Count	0.1	0.7	1.0	0.6	1.0	0.9
Smoking Status	0.1	0.1	0.4	0.0	0.2	0.6
Allergy or Eczema	0.1	0.2	0.5	0.0	0.3	0.7
Tanning	0.1	0.8	1.6	-0.7	-0.6	-1.3
Angina	0.1	0.1	0.2	-0.4	-0.2	0.5
Average weekly fortified wine intake	0.1	0.2	0.3	-0.6	-0.3	-0.2
Taking other prescription medications	0.1	0.1	0.2	-0.5	0.0	0.4
Age when periods started (menarche)	0.1	0.3	0.7	0.9	0.4	-0.2
Nervous feelings	0.1	0.1	0.3	-0.5	-0.2	0.4
Financial difficulties in last 2 years	0.1	0.1	0.2	0.4	-0.2	-0.2
Mouth/teeth dental problems	0.1	0.2	0.4	-0.4	-0.1	-0.6
Allergy	0.1	0.2	0.3	0.3	0.5	0.5
Diabetes (self-reported)	0.1	0.2	0.2	0.4	-0.5	-0.4
Neuroticism score	0.1	0.2	0.3	-0.4	-0.5	0.0
Impedance of arm (right)	0.1	0.3	0.7	0.1	0.4	0.9
Trunk fat-free mass	0.1	0.6	1.2	0.3	-0.8	-1.1
Depression (self-reported)	0.1	0.1	0.3	0.5	-0.0	0.3
Trunk predicted mass	0.1	0.7	1.4	0.1	-0.9	-1.2
Length of working week for main job	0.1	0.1	0.3	0.1	-0.2	-0.5
Tense / ‘highly strung’	0.1	0.2	0.4	-0.6	-0.2	0.2
Loud music exposure frequency	0.1	0.1	0.3	-0.3	0.5	-0.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	-0.3	-0.8	-0.3
Worry too long after embarrassment	0.1	0.1	0.1	-0.4	-0.1	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.1	0.1	-0.5
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	-0.5	0.5	0.0
Angina (self-reported)	0.1	0.2	0.2	-0.4	-0.4	0.4
Migraine (self-reported)	0.1	0.2	0.2	-0.3	0.5	-0.5
Suffer from ‘nerves’	0.1	0.1	0.4	-0.6	0.1	0.0
Age at last live birth	0.1	0.2	0.3	0.6	0.4	-0.3
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.4	-0.4	0.2
Illnesses of father: Heart disease	0.1	0.2	0.2	-0.4	-0.5	-0.3
Asthma (self-reported)	0.1	0.3	0.6	-0.8	-0.4	0.0
Medication: Gliclazide	0.1	0.1	0.1	-0.3	0.2	0.3
Mother’s age at death	0.1	0.1	0.3	0.5	0.4	-0.0
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.4	-0.3	-0.3
Alcohol drinker status: Never	0.1	0.1	0.3	-0.5	-0.0	0.3
HbA1C	0.0	0.0	0.1	-0.0	0.2	0.3
Rheumatoid Arthritis	0.0	0.0	0.1	-0.2	0.2	0.2
Height	0.0	0.4	0.5	0.7	0.7	0.4
Hypothyroidism (self reported)	0.0	0.1	0.2	0.0	-0.4	-0.1
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.0	0.1	-0.1	-0.1
Sitting height	0.0	0.1	0.1	0.4	0.2	0.1
Had menopause	0.0	0.0	0.1	0.1	-0.0	0.3
Standing height	0.0	0.1	0.2	0.3	0.5	-0.0
Number of full brothers	0.0	0.1	0.1	-0.1	-0.3	-0.2
Handedness (chirality/laterality): Left-handed	0.0	0.1	0.1	-0.1	0.2	0.4
Diabetes diagnosed by doctor	0.0	0.1	0.1	0.3	-0.3	-0.1
Commuting to job workplace: Public transport	0.0	0.0	0.1	-0.0	-0.3	-0.2
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	-0.2	0.1	0.0
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.1	-0.3	-0.1	-0.1

Hub : Genes

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Trait associations