[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1) : ← →

chr12:30,084,002-31,526,510

Best TWAS P=5.63e-12 · Best GWAS P=1.51e-12 conditioned to 1

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Nerve Tibial	IPO8	0.21	0.16	lasso	6	0.15	1.3e-10	-6.9	-6.9	5.6e-12	1.00	0.02	0.98	TRUE
7	GTEx	Skin Sun Exposed Lower leg	IPO8	0.23	0.08	lasso	10	0.13	1.1e-10	-7.0	-6.7	2.5e-11	0.87	0.02	0.98	FALSE
5	GTEx	Lung	IPO8	0.07	0.06	lasso	5	0.07	7.5e-06	4.5	-6.4	1.7e-10	0.77	0.10	0.90	FALSE
3	GTEx	Cells EBV-transformed lymphocytes	IPO8	0.22	0.14	lasso	4	0.14	2.5e-05	-7.0	-6.2	4.6e-10	0.88	0.02	0.97	FALSE
1	GTEx	Adipose Subcutaneous	IPO8	0.13	0.09	lasso	6	0.12	2.7e-10	4.5	-6.1	1.2e-09	0.79	0.30	0.70	FALSE
10	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IPO8	0.04	0.03	blup	58	0.03	9.7e-05	4.5	-5.7	1.2e-08	0.72	0.31	0.52	FALSE
9	The Cancer Genome Atlas	Lung Adenocarcinoma	IPO8	0.06	0.04	blup	58	0.04	1.5e-05	4.7	-5.7	1.4e-08	0.74	0.35	0.63	FALSE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	IPO8	0.05	0.03	lasso	3	0.03	1.3e-06	4.5	-5.3	1.0e-07	0.64	0.72	0.28	FALSE
2	GTEx	Artery Tibial	IPO8	0.17	0.14	lasso	4	0.14	4.5e-11	4.4	-5.2	2.2e-07	0.67	0.65	0.35	FALSE
4	GTEx	Esophagus Muscularis	IPO8	0.24	0.19	lasso	6	0.18	5.7e-11	4.8	-5.2	2.6e-07	0.60	0.97	0.03	FALSE