Best TWAS P=5.48e-11 · Best GWAS P=1.16e-09 conditioned to 0.251
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Atrial Appendage | SUOX | 0.09 | 0.10 | enet | 8 | 0.09 | 1.1e-04 | -4.8 | 5.2 | 1.9e-07 | -0.82 | 0.07 | 0.82 | FALSE |
| 2 | GTEx | Muscle Skeletal | RAB5B | 0.29 | 0.32 | lasso | 4 | 0.33 | 1.3e-33 | -5.9 | 5.9 | 2.9e-09 | -0.99 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Muscle Skeletal | SUOX | 0.11 | 0.04 | lasso | 7 | 0.04 | 4.4e-05 | -4.8 | 5.3 | 1.3e-07 | -0.82 | 0.25 | 0.68 | FALSE |
| 4 | GTEx | Muscle Skeletal | AC034102.1 | 0.28 | 0.31 | lasso | 4 | 0.31 | 2.3e-31 | -6.0 | 5.9 | 2.8e-09 | -0.99 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | RPS26 | 0.43 | 0.48 | lasso | 4 | 0.47 | 1.8e-30 | -4.8 | -5.1 | 3.1e-07 | 0.84 | 0.59 | 0.41 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | RAB5B | 0.03 | 0.02 | enet | 7 | 0.02 | 4.3e-03 | -5.9 | -6.6 | 5.5e-11 | 0.83 | 0.00 | 0.83 | TRUE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RPS26 | 0.22 | 0.31 | lasso | 3 | 0.31 | 1.6e-35 | -4.8 | -5.2 | 2.5e-07 | 0.84 | 0.65 | 0.35 | FALSE |
| 8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RPS26 | 0.30 | 0.20 | lasso | 4 | 0.24 | 3.9e-16 | -4.8 | -5.6 | 2.1e-08 | 0.91 | 0.02 | 0.97 | FALSE |
| 9 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | RPS26 | 0.28 | 0.15 | lasso | 2 | 0.17 | 3.0e-05 | -6.1 | -5.8 | 5.1e-09 | 0.98 | 0.00 | 0.98 | FALSE |