Hub : Genes

RAB5B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.2898	0.0471	0.0e+00	0.325	NA	0.327	NA	0.333	1.4e-32	NA	6.4e-33	NA	1.3e-33
2	TCGA	Breast Invasive Carcinoma	0.0170	0.0105	4.6e-03	0.019	0.007	0.006	NA	0.015	7.3e-05	1.1e-02	1.6e-02	NA	4.4e-04
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0418	0.0253	2.0e-03	0.026	0.024	0.009	NA	0.019	5.3e-04	8.2e-04	3.0e-02	NA	2.6e-03
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0660	0.0410	4.3e-03	-0.002	0.031	0.006	NA	-0.001	4.1e-01	7.0e-03	1.4e-01	NA	3.9e-01
5	TCGA	Lung Adenocarcinoma	0.0331	0.0226	6.7e-03	0.020	0.009	0.016	NA	0.015	1.9e-03	3.0e-02	4.3e-03	NA	6.5e-03
6	TCGA	Ovarian Serous Cystadenocarcinoma	0.0480	0.0270	3.6e-03	0.023	0.028	0.028	NA	0.011	1.1e-02	5.2e-03	5.3e-03	NA	5.9e-02
7	TCGA	Thyroid Carcinoma	0.1140	0.0570	2.3e-06	0.033	0.076	0.057	NA	0.057	3.4e-04	7.0e-08	3.3e-06	NA	3.1e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.7	1.0	2.7	-1.4	0.0	0.5	1.6	0.0	1.1	1.1
Bipolar Disorder or Schizophrenia	0.4	1.0	2.3	-1.1	0.0	1.0	1.5	0.0	0.8	1.3
Depressed Affect (Nagel 2018)	0.2	0.5	1.2	1.1	0.1	0.6	0.6	-1.1	0.5	0.2
Depression (Nagel 2018)	0.2	0.3	0.6	0.3	0.6	0.6	0.7	-0.6	0.4	0.5
Intelligence (Savage-Jansen 2018)	2.2	6.8	21.3	-4.6	-0.8	-0.6	1.8	3.9	1.6	2.0
Neuroticism (Nagel 2018)	0.7	1.6	2.9	0.9	0.8	1.5	1.7	-1.3	1.3	1.1
Schizophrenia (2018)	0.1	0.3	0.7	-0.2	0.0	0.8	0.6	0.0	0.2	0.8
Schizophrenia vs Biploar Disorder	0.4	0.5	2.5	1.6	0.0	0.5	-0.8	0.0	-0.5	-0.3
Worry (Nagel 2018)	0.7	1.4	3.7	0.1	0.9	1.1	1.9	-0.8	1.5	1.1
Alzheimer’s Disease (in mother)	1.0	1.2	1.8	1.2	-1.1	-0.8	-1.3	-0.4	-1.1	-1.4
Alzheimer’s Disease (in father)	1.2	1.3	2.3	0.7	-1.4	-1.2	-1.3	-0.1	-1.2	-1.5
Alzheimer’s Disease (including proxy)	2.1	3.0	5.1	1.7	-2.1	-1.5	-1.9	-0.7	-1.6	-2.3
Crohns Disease (2017)	0.8	1.8	3.2	-0.8	1.6	1.2	1.4	0.1	1.6	1.8
Irritable Bowel Disease (IBD)	0.2	0.5	1.0	-0.6	0.3	0.4	1.0	0.5	1.0	1.0
Ulcerative Colitis (UC)	0.2	0.3	1.2	-0.2	-1.1	-0.6	0.1	0.7	-0.0	-0.1
Major Depression (MDD)	0.1	0.1	0.3	0.2	0.0	0.1	-0.2	0.0	-0.5	0.3
Reaction Time	4.0	7.7	15.3	3.9	-1.5	-0.5	-3.7	-2.9	-3.0	-2.2
Verbal and Numeric Reasoning (VNR)	2.6	6.1	21.0	-4.6	-0.8	-0.9	2.0	3.6	1.3	1.4
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	4.0	5.3	8.5	2.0	-2.5	-2.0	-2.7	-1.2	-2.4	-2.9
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	3.8	5.5	14.0	-3.7	1.1	0.2	2.0	3.7	1.2	1.9
Bipolar Disorder (2011)	0.9	0.8	1.9	-1.4	0.0	0.3	1.4	0.0	1.1	0.8
Body Mass Index (BMI) (2010)	1.3	1.8	2.7	1.6	0.0	-0.9	-1.4	-1.6	-1.4	-1.5
Coronary Artery Disease (CAD)	0.2	0.2	0.7	-0.8	0.0	-0.6	-0.0	0.0	-0.5	-0.1
Crohns Disease (2012)	0.6	0.9	2.1	-0.2	0.0	1.5	1.3	0.0	1.0	1.4
Mean Putamen Volume	0.4	0.5	1.5	-1.2	-0.1	-0.3	0.6	1.2	0.2	-0.1
Fasting Glucose	0.6	0.8	2.8	1.7	0.4	0.6	-0.2	-1.4	0.1	0.1
HbA1C	0.3	0.3	0.6	-0.3	-0.6	-0.7	-0.6	0.7	-0.8	-0.1
HDL Cholesterol	0.4	0.6	2.0	-1.4	0.0	-0.3	0.6	0.9	0.7	0.8
LDL Cholesterol	1.2	1.8	5.2	-0.3	0.0	1.6	1.1	-0.2	2.3	2.0
Lupus	4.4	6.7	12.3	-3.0	1.5	1.4	3.0	2.3	3.5	2.6
Neuroticism (2016)	1.0	1.4	3.0	0.6	-1.4	-1.3	-0.9	-0.3	-1.4	-1.7
Primary Biliary Cirrhosis	2.1	3.1	9.2	2.9	0.2	1.2	-1.4	-3.0	-0.5	0.1
Rheumatoid Arthritis	1.7	2.3	7.5	2.4	0.0	2.7	0.5	0.0	0.8	1.4
Schizophrenia (2014)	0.1	0.3	1.1	0.2	0.0	1.0	0.7	0.0	0.5	0.7
Triglycerides	1.1	1.9	3.3	1.8	0.0	-0.8	-1.5	-1.6	-1.2	-1.7
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.7	-0.8	0.0	0.3	0.3	0.0	-0.2	0.2
Ulcerative Colitis	0.0	0.0	0.1	0.3	0.0	0.3	0.2	0.0	0.3	0.0
Blood Eosinophil Count	5.9	45.6	146.4	-12.1	1.1	-2.1	6.0	10.1	4.2	3.4
Blood Platelet Count	0.8	9.0	17.1	-1.7	2.8	2.8	3.7	2.2	4.1	2.9
Blood Red Count	0.5	4.9	16.6	4.1	1.6	2.2	-0.5	-3.0	-1.0	-0.3
Blood White Count	0.2	1.5	4.1	2.0	0.8	0.9	-0.9	-1.7	-0.9	-0.3
Heel T-Score	3.0	23.9	34.3	-5.4	4.0	3.0	5.8	4.0	5.4	5.9
BMI	3.0	17.6	53.3	7.3	-0.2	1.5	-4.2	-5.7	-3.5	-2.4
Height	0.2	3.5	13.5	1.6	-0.5	-1.1	-1.5	-3.7	-1.6	-1.6
Waist Hip Ratio (WHR)	0.5	2.4	3.8	-0.5	2.0	1.6	1.7	1.8	1.5	1.3
Systolic Blood Pressure	0.7	3.6	10.6	3.3	0.1	0.2	-1.9	-2.1	-1.9	-1.8
Smoking Status	4.1	9.9	27.1	5.2	0.2	0.3	-3.0	-4.2	-3.1	-2.5
Allergy or Eczema	9.0	23.8	76.9	-8.8	-0.9	-2.5	4.4	6.7	3.6	2.5
Cardiovascular Disease	1.8	5.8	16.2	4.0	0.3	0.6	-2.9	-2.9	-2.5	-0.9
Hypothyroidism (self reported)	9.5	21.9	61.8	-7.9	0.1	-0.5	4.6	6.3	4.3	3.5
Respiratory disease	10.3	22.9	73.8	-8.6	-0.2	-2.1	3.8	7.3	2.9	2.4
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.3	0.1	0.6	0.4	-0.0	0.1	0.0	0.4
Lung FEV1/FVC ratio	5.5	28.1	74.0	8.6	-1.4	0.4	-4.4	-8.4	-3.6	-4.2
Lung FVC	1.4	7.2	23.7	4.9	0.5	1.6	-1.4	-4.4	-1.6	-0.7
Neuroticism	0.5	1.3	3.0	0.5	1.0	1.2	1.7	-0.8	1.5	0.9
Chronotype (morning person)	1.0	2.3	6.5	-1.2	1.1	1.0	2.2	1.1	2.5	0.7
Hair Pigment	0.2	6.1	12.1	3.5	2.6	3.2	0.5	-3.4	1.1	0.9
Tanning	0.7	8.6	15.1	1.6	-3.5	-2.6	-3.9	-2.1	-3.5	-2.6
Hand grip strength (left)	0.2	0.5	1.3	0.0	-0.3	-0.5	-0.6	0.6	-1.1	-1.1
Number of treatments/medications taken	1.0	1.9	4.2	1.7	0.9	2.1	0.5	-1.1	1.6	1.1
Average weekly spirits intake	1.6	2.0	3.0	-1.2	1.6	1.4	1.3	1.7	0.8	1.6
Sensitivity / hurt feelings	1.4	2.3	4.3	0.3	1.9	1.8	2.1	0.1	1.8	1.4
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.2	1.2	-0.3	0.1	0.0	-1.5	0.1	-0.5
Hearing difficulty/problems: Yes	0.1	0.2	0.4	0.7	-0.1	-0.1	-0.3	-0.6	-0.3	-0.3
Relative age of first facial hair	2.2	4.5	8.1	-2.7	0.7	0.4	2.8	2.5	2.6	1.5
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	4.4	-0.4	1.5	1.6	1.5	0.1	1.6	2.1
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.4	-0.8	1.1	1.0	0.7	1.6	0.8	1.3
Ever had hysterectomy (womb removed)	1.5	1.7	3.3	-0.4	1.0	1.6	1.4	0.3	1.8	1.7
Systolic blood pressure, automated reading	0.5	1.3	5.2	2.3	0.5	1.0	-0.1	-1.6	-0.2	-0.7
Eye problems/disorders: Diabetes related eye disease	3.1	3.4	5.9	-2.1	1.0	1.1	2.4	1.7	2.0	2.1
Angina	3.0	4.0	7.7	-0.7	2.8	2.4	1.7	0.7	1.9	2.6
Medication for hormone replacement therapy	0.3	0.3	1.2	-1.1	-0.3	-0.3	0.8	0.1	0.4	0.5
Vitamin and mineral supplements	1.9	2.6	5.7	-0.9	-2.3	-2.4	-0.7	0.4	-1.7	-1.8
Supplements: Zinc	0.2	0.2	0.8	0.3	-0.2	-0.4	-0.2	-0.9	-0.1	-0.2
Medication: Co-codamol	0.8	0.9	1.8	0.1	1.1	1.3	1.0	0.7	1.0	0.7
Medication: Metformin	0.2	0.3	1.1	-0.6	0.6	0.3	0.2	0.3	0.4	1.1
Diabetes (father)	0.6	0.7	1.2	1.1	-0.1	-0.5	-0.8	-0.9	-1.0	-0.9
Diabetes (mother)	1.2	1.5	4.4	1.9	-0.7	-0.3	-0.9	-2.1	-0.5	-1.0
Severe depression (siblings)	0.5	0.6	1.2	-1.1	0.7	0.2	0.8	0.9	0.9	0.3
Pack years adult smoking proportion	0.2	0.4	0.9	0.7	-1.0	-0.2	-0.6	-0.8	0.0	-0.3
Impedance of leg (right)	2.8	13.7	42.5	-6.5	0.8	-1.5	3.1	5.3	2.4	2.6
Leg fat-free mass (left)	3.2	17.1	42.1	6.5	-1.5	0.3	-4.0	-5.7	-3.7	-3.6
Trunk fat percentage	0.9	3.5	5.4	2.2	-1.5	-1.0	-2.3	-1.8	-2.0	-1.9
Hand grip strength (right)	0.8	2.1	3.7	-0.0	-1.9	-1.6	-1.6	0.7	-1.6	-1.6
Townsend deprivation index at recruitment	1.3	1.8	6.5	2.6	1.0	0.9	-0.6	-2.0	-0.3	-0.4
Current tobacco smoking	0.7	1.1	3.7	1.6	0.6	0.6	-0.4	-1.9	-0.5	-0.3
Average weekly fortified wine intake	2.2	2.6	8.1	-2.9	-1.3	-1.4	0.3	2.5	0.1	0.1
Maternal smoking around birth	2.5	3.6	6.3	2.5	-1.9	-0.7	-2.2	-2.5	-1.5	-1.4
Fed-up feelings	0.7	1.2	3.9	2.0	-0.6	-0.1	-0.8	-1.6	-0.4	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.1	1.8	-0.6	-0.2	-1.0	-1.1	-0.7	-1.4
Relative age voice broke	1.3	2.0	4.0	-2.0	0.8	0.1	1.6	1.2	1.6	1.5
Taking other prescription medications	1.1	1.7	4.5	-1.1	0.5	1.0	1.4	0.3	1.7	2.1
Age when periods started (menarche)	2.1	5.0	11.3	-3.4	-2.2	-2.9	-0.1	3.1	-0.0	-0.9
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	-0.4	0.6	0.5	0.3	0.3	0.4	0.7
Heel bone mineral density (BMD) T-score, automated (left)	3.7	8.5	12.4	-1.1	3.2	3.5	3.4	1.0	3.3	3.5
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	4.8	2.1	-0.9	-0.8	-1.8	-1.7	-2.1	-2.2
Qualifications: CSEs or equivalent	1.9	2.5	4.8	2.2	-0.5	-0.5	-1.7	-1.3	-2.0	-1.9
Serious illness, injury or assault to yourself	0.7	0.9	2.0	-0.8	0.9	0.7	1.4	0.8	1.1	0.6
High blood pressure	2.1	5.7	16.4	4.0	0.5	0.7	-2.0	-3.8	-1.8	-1.1
Hayfever, allergic rhinitis or eczema	6.7	14.5	47.0	-6.9	-1.7	-3.0	2.7	5.4	2.3	1.1
Multivitamins +/- minerals	0.7	0.8	1.9	0.5	1.2	1.4	-0.1	-0.1	1.0	1.1
Stomach or abdominal pain in last month	0.5	0.6	1.8	1.3	0.8	1.0	-0.1	-0.7	0.1	0.2
Supplements: Glucosamine	1.3	1.7	3.5	0.4	0.9	1.8	1.4	-0.6	1.9	1.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.4	-0.1	1.2	1.1	0.3	0.0	0.9	1.2
Medication: Atenolol	2.1	2.7	3.9	-0.4	1.9	1.9	2.0	0.3	1.8	2.0
Medication: Levothyroxine sodium	10.4	17.6	39.9	-6.3	1.0	0.6	4.2	5.8	3.9	4.0
Sitting height	0.4	2.7	5.6	1.6	-0.3	-0.7	-1.4	-2.1	-2.4	-1.9
Chronic bronchitis/emphysema (father)	0.4	0.4	1.2	-1.1	-0.1	-0.1	0.3	0.8	0.6	0.8
High blood pressure (mother)	4.0	5.6	9.2	1.4	-2.4	-2.4	-3.0	-1.5	-2.4	-2.9
Body mass index (BMI)	3.1	13.3	38.6	6.2	-0.9	0.8	-3.7	-4.9	-2.9	-2.7
Impedance of leg (left)	2.6	12.7	39.7	-6.3	0.7	-1.5	2.9	5.2	2.3	2.4
Leg predicted mass (left)	3.2	16.7	41.5	6.4	-1.5	0.3	-3.9	-5.6	-3.6	-3.5
Trunk fat mass	1.6	6.8	13.8	3.7	-1.3	-0.5	-3.0	-3.2	-2.6	-2.4
Waist circumference	1.8	6.5	19.9	4.5	-0.2	0.7	-2.5	-3.5	-1.9	-1.8
Number of incorrect matches in round	0.1	0.2	0.7	0.8	0.4	0.5	-0.0	-0.5	0.1	0.1
Past tobacco smoking	3.0	5.5	14.8	-3.8	-0.2	-0.3	2.1	3.1	2.2	2.1
Alcohol usually taken with meals	2.9	4.6	14.1	-3.4	0.5	-0.2	2.2	3.8	1.2	0.7
Nervous feelings	1.2	2.2	4.2	-0.4	1.5	1.5	1.9	-0.5	1.7	2.1
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.6	0.4	1.2	1.6	1.2	-0.3	1.5	1.2
Hearing difficulty/problems with background noise	1.4	2.2	7.9	2.6	0.0	0.7	-0.3	-2.8	0.2	-0.6
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	0.2	0.7	0.4	0.7	-0.1	0.4	0.1
Had menopause	0.9	1.1	3.7	-1.2	0.0	0.3	1.2	1.9	0.8	0.5
Had other major operations	3.4	4.2	9.2	-0.6	-2.8	-3.0	-2.0	0.4	-1.5	-2.3
Forced vital capacity (FVC)	2.3	8.7	19.0	3.9	-1.4	-1.0	-2.8	-4.4	-3.0	-2.8
Heel bone mineral density (BMD) T-score, automated (right)	2.3	5.2	8.7	-1.0	2.2	2.5	2.9	1.1	2.7	2.6
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.9	-0.8	0.1	-0.9	-0.6	0.5	-0.4	-0.5
Qualifications: None of the above	5.7	12.1	38.4	6.2	0.7	1.7	-1.6	-6.2	-0.6	-1.3
Financial difficulties in last 2 years	0.3	0.4	1.8	1.3	0.1	0.7	-0.6	-0.5	-0.4	-0.1
Mouth/teeth dental problems	2.4	3.6	7.8	-1.6	-2.4	-2.8	-1.1	1.4	-1.8	-1.6
Heart attack	0.9	1.1	2.4	-0.4	1.3	1.0	1.1	-0.5	1.1	1.6
Allergy	9.6	22.0	69.1	8.3	0.9	2.5	-3.6	-7.0	-3.2	-2.3
Pain all over the body in last month	3.2	3.5	9.6	2.3	-1.6	-0.6	-2.0	-3.1	-1.1	-0.9
Diabetes (self-reported)	0.6	0.9	2.5	-1.3	0.7	0.2	0.4	1.6	0.2	1.0
Hayfever/allergic rhinitis (self-reported)	4.4	5.8	18.3	-4.3	-0.4	-1.1	2.2	3.0	2.2	1.4
Medication: Ramipril	0.2	0.3	1.0	0.5	0.1	-0.2	-0.7	-1.0	-0.3	-0.2
Medication: Simvastatin	0.8	1.2	2.9	-1.0	0.7	1.0	0.8	1.0	1.2	1.7
Fluid intelligence score	2.6	5.3	16.7	-4.1	-0.6	-1.1	1.1	4.0	0.7	1.1
Illnesses of siblings	0.8	1.2	4.2	-2.0	0.1	-0.6	0.4	1.8	-0.1	0.5
Neuroticism score	0.6	1.2	2.2	0.7	0.8	1.1	1.5	-1.1	1.5	0.7
Weight	3.3	16.0	39.0	6.2	-1.5	0.1	-4.2	-5.4	-3.6	-3.4
Impedance of arm (right)	3.1	14.5	48.7	-7.0	-0.5	-2.7	2.8	5.7	1.9	1.2
Arm fat percentage (right)	1.6	6.4	14.6	3.8	-1.3	-0.5	-2.8	-2.8	-2.4	-2.6
Trunk fat-free mass	2.7	15.5	41.8	6.5	-0.6	1.1	-3.5	-6.0	-3.2	-2.7
Hip circumference	2.6	11.0	18.4	4.3	-2.1	-1.2	-3.8	-3.8	-3.4	-3.5
Time employed in main current job	0.2	0.3	0.7	-0.7	-0.1	0.3	0.5	0.8	0.2	0.6
Alcohol intake versus 10 years previously	1.4	2.1	5.5	2.3	-0.4	0.3	-2.0	-1.4	-1.3	-1.2
Father’s age at death	1.3	1.7	3.4	-0.8	-1.1	-1.8	-1.7	0.7	-1.6	-1.0
Worrier / anxious feelings	0.8	1.5	3.4	-0.4	0.9	0.9	1.8	-0.6	1.7	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	8.5	2.8	-0.3	0.2	-0.8	-2.9	-0.5	-1.0
Falls in the last year	1.1	1.5	3.4	1.8	1.8	1.8	0.1	-0.7	0.4	0.2
Hair/balding pattern: Pattern 3	0.4	0.6	2.1	-0.1	-1.5	-0.6	-1.0	0.4	-0.4	-0.4
Number of live births	2.5	3.6	5.1	2.2	-2.1	-1.1	-2.0	-1.8	-1.6	-2.1
Forced expiratory volume in 1-second (FEV1)	5.5	18.4	43.0	5.9	-2.0	-1.0	-3.9	-6.6	-3.9	-3.9
Pulse rate	3.0	5.1	8.5	2.8	-1.0	-0.9	-2.6	-2.9	-2.6	-2.0
Happiness	1.1	1.4	2.5	-0.2	-1.3	-1.6	-1.5	0.3	-1.2	-1.3
Noisy workplace	0.7	0.8	2.1	1.4	-0.3	1.0	-0.3	-1.4	0.7	0.4
Qualifications: A levels/AS levels or equivalent	2.7	6.0	18.4	-4.3	-0.6	-1.2	2.2	3.5	1.6	1.4
Serious illness, injury or assault of a close relative in last 2 years	8.4	9.6	15.1	-3.6	2.4	1.6	3.9	3.5	3.2	2.9
Mouth/teeth dental problems: Dentures	0.5	0.8	2.2	0.5	1.3	1.5	0.6	-0.2	0.7	0.9
Asthma	10.3	20.3	62.4	-7.9	-0.2	-1.7	3.2	7.4	2.4	2.5
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	4.5	2.1	0.0	0.5	-0.7	-1.6	-0.7	-0.8
Medication: Cholesterol lowering	1.9	3.0	6.1	-0.0	2.4	2.3	1.3	-0.2	1.6	2.5
Depression (self-reported)	0.8	1.0	2.1	0.6	-0.7	-0.7	-1.2	0.2	-1.5	-1.3
Medication: Lansoprazole	2.6	2.9	4.6	1.5	-1.7	-1.3	-2.1	-1.2	-2.2	-1.8
Prospective memory result	1.1	1.3	3.4	-0.3	0.9	1.0	1.8	-0.0	1.8	0.5
Lung cancer (father)	3.0	3.5	10.1	2.4	-1.4	-0.4	-2.1	-3.2	-1.4	-1.0
Illnesses of mother	1.7	2.1	4.7	-0.8	1.3	1.6	1.6	0.7	1.5	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	5.4	17.3	46.2	6.3	-1.5	-0.3	-3.4	-6.8	-3.2	-3.4
Pulse wave Arterial Stiffness index	0.2	0.2	0.8	0.6	-0.2	0.1	-0.4	-0.0	-0.1	-0.9
Impedance of arm (left)	3.4	15.7	52.9	-7.3	-0.6	-2.8	2.8	6.0	1.9	1.4
Arm fat mass (right)	3.2	13.0	31.5	5.6	-1.4	-0.2	-3.8	-4.5	-3.4	-3.3
Trunk predicted mass	2.7	15.6	41.8	6.5	-0.6	1.0	-3.5	-6.0	-3.2	-2.7
Standing height	0.3	2.5	3.9	1.1	-1.1	-1.2	-1.5	-2.0	-1.9	-1.9
Length of working week for main job	1.2	1.4	2.9	-0.0	1.2	1.2	1.5	-0.3	1.7	1.3
Exposure to tobacco smoke at home	0.5	0.5	1.1	0.2	-0.8	-0.7	-1.1	0.4	-0.8	-0.8
Breastfed as a baby	1.5	1.9	6.0	-2.1	-0.2	-1.3	0.4	2.4	-0.5	-0.4
Tense / ‘highly strung’	0.6	1.0	2.6	0.6	1.1	1.6	1.1	0.2	1.2	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.3	0.7	-0.5	-1.0	-0.8	-1.2	-1.1	-1.1
Hair/balding pattern: Pattern 4	0.2	0.5	2.1	-1.4	-0.0	-0.5	0.5	0.9	0.6	0.4
Birth weight of first child	3.7	6.7	19.0	-4.4	-0.1	-0.2	2.9	3.0	2.2	2.4
Peak expiratory flow (PEF)	3.4	7.8	11.3	2.0	-2.8	-2.5	-3.1	-2.3	-3.4	-3.2
Pulse wave reflection index	0.3	0.4	0.8	-0.6	0.5	0.5	0.6	0.7	0.9	0.4
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.8	-0.4	0.9	0.4	0.6	0.3	0.5	0.2
Loud music exposure frequency	0.9	0.9	2.8	1.7	-0.7	-0.0	-0.4	-1.3	-0.2	-1.1
Qualifications: O levels/GCSEs or equivalent	2.1	3.3	9.3	-3.1	0.0	-0.6	1.6	2.9	1.0	1.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.9	1.4	1.1	1.2	0.1	-0.7	0.5	0.3
Blood clot in the leg (DVT)	0.2	0.3	1.1	1.0	-0.4	0.2	0.0	-0.1	-0.0	-0.8
Medication: Paracetamol	3.0	5.0	14.9	3.9	-0.4	0.6	-1.5	-3.5	-1.4	-1.7
Headache pain in last month	6.9	11.8	28.2	5.3	-2.0	-0.6	-3.4	-4.5	-2.8	-3.4
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	3.9	-1.3	-1.5	-1.8	-0.5	2.0	-1.2	-1.7
Glaucoma (self-reported)	0.0	0.1	0.1	-0.2	-0.2	-0.2	-0.4	0.2	-0.3	0.1
Gout (self-reported)	1.3	1.8	6.6	2.6	0.3	1.1	-1.0	-1.9	-0.2	-0.3
Hypothyroidism/myxoedema (self-reported)	9.0	17.7	45.4	-6.7	0.2	0.0	4.0	6.0	3.6	3.6
Medication: Amlodipine	0.5	0.7	1.5	1.0	-0.3	-0.3	-1.2	-0.5	-1.0	-0.8
Medication: Ventolin 100micrograms inhaler	5.5	7.1	22.3	-4.4	-0.0	-1.3	2.0	4.7	1.2	0.9
Birth weight	1.3	2.9	7.2	-2.7	-2.3	-2.0	-0.0	1.9	-0.2	-0.2
Chronic bronchitis/emphysema (mother)	1.6	1.9	3.6	-0.4	-1.9	-1.8	-0.7	1.2	-1.0	-1.9
High blood pressure (siblings)	2.0	2.9	7.0	2.6	-1.2	-0.4	-1.6	-2.2	-0.8	-1.9
Forced vital capacity (FVC), Best measure	2.6	9.4	25.2	4.4	-1.1	-0.4	-2.5	-5.0	-2.6	-2.6
Body fat percentage	1.0	3.9	7.3	2.7	-1.2	-0.6	-2.4	-2.2	-2.0	-1.9
Leg fat percentage (right)	0.6	2.2	6.4	2.5	-0.2	0.2	-1.7	-2.0	-1.2	-0.9
Arm fat-free mass (right)	2.7	14.0	40.2	6.3	-0.4	1.3	-3.3	-5.4	-3.0	-2.4
Exposure to tobacco smoke outside home	1.7	2.2	5.4	2.3	1.7	2.1	0.1	-1.5	0.6	0.3
Comparative body size at age 10	0.2	0.6	1.4	-0.0	0.5	1.1	0.5	0.7	1.2	0.8
Number of full brothers	1.4	1.8	7.7	2.1	0.2	0.6	-0.3	-2.8	0.2	-0.2
Worry too long after embarrassment	0.7	1.1	3.7	-1.1	0.8	0.4	1.9	0.4	1.0	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.8	1.0	-1.1	-1.0	-1.0	-1.7	-1.0	-1.1
Wheeze or whistling in the chest in last year	2.1	3.8	7.5	-1.5	1.4	1.4	2.3	1.8	2.7	2.1
Number of children fathered	0.7	0.8	2.7	1.6	0.6	1.1	0.2	-1.2	0.1	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	3.5	4.1	12.7	-3.3	-1.6	-1.5	0.2	3.6	0.5	0.3
Age at first live birth	3.2	5.6	19.6	-4.4	-0.1	-1.9	1.1	3.8	-0.1	0.7
Pulse wave peak to peak time	0.2	0.2	0.7	-0.6	0.2	-0.1	0.4	-0.1	-0.0	0.9
Health satisfaction	0.1	0.2	0.5	-0.5	0.4	0.0	0.0	0.7	-0.1	0.4
Shortness of breath walking on level ground	2.3	2.7	6.5	0.0	-1.2	-1.9	-2.4	0.1	-2.5	-1.4
Qualifications: College or University degree	3.5	10.9	35.9	-6.0	-1.0	-1.9	2.1	5.1	1.7	1.5
Eye problems/disorders: None of the above	2.1	2.4	4.0	1.6	-1.3	-1.2	-1.5	-1.6	-1.5	-2.0
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.5	0.4	0.7	0.3	0.1	-0.6	0.0	0.1
Emphysema/chronic bronchitis	1.8	2.0	4.0	-1.5	0.9	0.5	1.9	1.0	2.0	1.3
Medication for pain relief, constipation, heartburn	1.5	2.6	8.6	-2.9	-0.5	-1.3	0.6	2.6	0.2	0.5
Neck or shoulder pain in last month	2.4	3.3	11.2	3.4	1.5	1.7	-1.0	-2.3	-0.3	-0.6
Medication: Blood pressure	1.1	2.0	8.3	1.8	0.9	1.0	-0.6	-2.9	-0.0	0.7
Angina (self-reported)	3.7	4.9	8.7	-1.2	2.9	2.4	2.0	1.2	2.2	2.9
Migraine (self-reported)	2.8	3.4	7.2	2.7	-1.2	-0.4	-1.9	-2.7	-1.3	-1.6
Medication: Ibuprofen	0.6	0.7	2.2	1.5	-0.2	0.0	-0.9	-0.9	-0.7	-0.9
Medication: Allopurinol	1.6	2.1	7.3	2.7	-0.1	1.2	-0.8	-2.3	0.3	-0.1
Medication: Omeprazole	3.1	3.7	9.5	3.1	-1.2	0.1	-1.5	-3.0	-1.3	-1.4
Medication: Seretide 50 evohaler	5.5	6.3	11.7	-3.4	0.9	0.4	3.1	3.2	2.7	2.2
Mean time to correctly identify matches	3.6	6.9	12.9	3.3	-1.5	-0.9	-3.6	-2.8	-2.7	-2.4
Heart disease (mother)	0.4	0.5	0.9	-0.3	0.9	0.6	0.6	-0.3	0.8	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.7	0.1	-1.6	-0.7	-0.9	-0.6	0.7	0.0
Whole body fat mass	2.2	9.2	20.5	4.5	-1.3	-0.3	-3.4	-3.8	-3.0	-2.7
Leg fat mass (right)	2.4	9.1	23.5	4.8	-0.9	0.2	-3.2	-4.1	-2.7	-2.2
Arm predicted mass (right)	2.8	14.5	41.7	6.5	-0.4	1.4	-3.4	-5.5	-3.1	-2.4
Pulse rate, automated reading	2.7	8.7	21.8	4.7	-0.9	-0.3	-2.8	-4.2	-2.4	-2.6
Alcohol intake frequency.	3.3	7.7	18.6	4.3	-0.2	0.0	-3.0	-3.7	-2.8	-2.1
Comparative height size at age 10	0.5	2.6	7.4	2.1	-0.7	-0.2	-1.5	-2.7	-1.4	-1.3
Number of full sisters	1.7	2.1	7.3	2.7	0.8	1.2	-0.2	-2.2	-0.1	-0.6
Suffer from ‘nerves’	0.9	1.4	3.1	1.8	1.0	1.4	0.7	-1.7	0.6	0.1
Overall health rating	2.1	4.5	10.7	2.3	3.3	2.9	0.7	-1.9	0.8	1.5
Chest pain or discomfort	0.3	0.5	1.5	1.2	0.7	0.6	0.1	-1.0	0.1	0.1
Had major operations	0.5	0.5	1.3	1.0	0.4	0.9	-0.1	-1.1	0.5	0.5
Age at last live birth	2.5	3.7	9.2	-1.6	-1.9	-3.0	-1.3	1.4	-2.1	-1.6
Family relationship satisfaction	3.2	3.9	6.6	2.1	-1.6	-1.4	-2.1	-2.6	-1.6	-2.1
Leg pain on walking	0.5	0.6	2.6	1.1	0.7	0.4	-0.1	-1.6	0.0	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.4	0.4	-0.2	-0.4	-0.6	-0.0	-1.2	-1.0
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.3	-0.4	-0.0	-0.1	-0.4	-0.2	0.1
Illness, injury, bereavement, stress in last 2 years	2.6	3.2	5.8	-0.1	-1.8	-2.3	-2.1	-0.0	-2.4	-1.9
Medication: Aspirin	2.6	3.5	6.4	-0.5	2.4	2.3	1.7	0.0	1.9	2.5
Supplements: Vitamin C	2.1	2.5	5.1	-0.7	1.8	1.9	1.6	0.3	1.7	2.3
Knee pain experienced in last month	1.5	2.3	5.3	1.2	2.2	2.3	0.8	-0.9	1.1	1.5
Hypertension (Self-reported)	2.1	5.9	17.2	4.1	0.6	0.9	-1.9	-3.9	-1.8	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.6	3.0	8.8	3.0	0.2	0.7	-1.4	-2.8	-1.2	-0.7
Illnesses of father: Heart disease	5.5	7.7	11.5	-2.8	2.6	2.0	2.9	3.4	2.7	2.9
Illnesses of siblings: Diabetes	0.2	0.2	0.7	-0.2	0.8	0.3	0.3	-0.1	-0.1	0.6
Smoking status: Previous	4.6	6.9	16.0	4.0	-0.5	-0.3	-2.7	-3.3	-2.6	-2.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.1	1.5	0.7	0.4	-0.6	-1.7	-0.8	-0.5
Whole body fat-free mass	3.0	17.4	45.6	6.8	-1.0	0.8	-3.9	-6.0	-3.6	-3.2
Leg fat-free mass (right)	3.3	17.8	43.0	6.6	-1.6	0.2	-4.1	-5.7	-3.9	-3.7
Arm fat percentage (left)	1.4	5.5	11.4	3.4	-1.4	-0.6	-2.7	-2.5	-2.4	-2.4
Average weekly red wine intake	0.5	0.7	2.2	-1.5	-0.4	-0.4	0.6	1.3	0.0	0.4
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.6	-0.7	-0.4	-0.6	0.6	0.7	-0.2	-0.4
Mood swings	1.1	2.0	6.7	2.6	-0.3	0.4	-0.4	-2.4	-0.3	-0.8
Loneliness, isolation	1.5	2.1	4.2	1.9	1.7	2.0	0.8	-1.7	0.7	0.8
Long-standing illness, disability or infirmity	1.6	2.4	5.1	-1.2	1.1	1.1	1.9	1.1	2.2	1.7
Ever had bowel cancer screening	0.4	0.4	1.3	0.6	0.7	1.1	0.2	-0.1	0.4	0.9
Diabetes diagnosed by doctor	0.1	0.1	0.2	-0.4	0.0	-0.4	-0.3	0.3	-0.5	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.9	1.2	-0.3	-0.6	-1.1	-0.9	-1.1	-1.4
Friendships satisfaction	1.2	1.5	3.2	0.0	-1.8	-1.7	-1.6	-0.6	-1.0	-0.9
Qualifications: nursing, teaching	1.0	1.6	5.5	-2.3	0.4	-0.4	0.3	1.8	0.0	1.4
Commuting to job workplace: Walk	0.3	0.3	0.6	0.5	0.6	0.8	0.4	-0.2	0.7	0.6
Eye problems/disorders: Cataract	0.5	0.6	1.8	-1.3	0.5	0.1	0.8	0.6	0.6	1.0
Mouth/teeth dental problems: Mouth ulcers	2.5	4.0	8.1	2.6	2.0	2.4	1.0	-2.9	1.3	0.9
Medication for cholesterol	0.9	1.3	3.5	-1.9	-0.6	-1.5	-0.0	1.7	-0.4	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.6	0.3	-0.0	0.2	-0.8	0.1	-0.1	-0.1
Back pain experienced in last month	1.2	1.8	3.3	1.8	1.8	1.4	0.7	-1.8	0.3	0.2
Mineral and other dietary supplements	0.8	1.1	1.9	-1.3	-0.8	-1.4	-0.8	1.0	-1.4	-0.4
Breast cancer (self-reported)	0.4	0.5	2.1	-0.8	-1.5	-0.8	-0.1	-0.1	0.2	-0.0
Asthma (self-reported)	10.9	21.7	66.4	-8.2	-0.1	-1.6	3.5	7.5	2.7	2.7
Osteoporosis (self-reported)	0.4	0.5	1.3	0.7	1.2	0.9	0.4	-0.7	0.3	0.5
Osteoarthritis (self-reported)	0.3	0.3	1.0	1.0	0.2	0.8	0.3	-0.8	0.3	0.1
Medication: Aspirin	1.7	2.3	4.7	-0.1	1.9	1.9	1.2	-0.6	1.4	2.2
Medication: Gliclazide	0.2	0.2	0.5	0.7	0.2	0.4	-0.4	-0.6	-0.4	0.2
Illnesses of father: None of the above (group 1)	1.7	2.1	3.5	0.9	-1.9	-1.4	-1.7	-1.5	-1.3	-1.4
Smoking status: Current	1.1	1.7	5.7	2.0	0.9	1.0	-0.4	-2.4	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.7	5.8	17.1	4.1	-0.6	0.3	-1.4	-3.9	-1.5	-1.6
Whole body water mass	3.0	17.1	44.9	6.7	-1.0	0.8	-3.9	-6.0	-3.5	-3.2
Leg predicted mass (right)	3.3	17.8	43.1	6.6	-1.6	0.2	-4.1	-5.7	-3.9	-3.8
Arm fat mass (left)	2.9	11.9	28.4	5.3	-1.5	-0.2	-3.8	-4.3	-3.3	-3.1
Number of self-reported non-cancer illnesses	0.4	0.6	1.4	-0.7	0.7	0.5	0.9	0.1	0.9	1.2
Average weekly champagne plus white wine intake	3.0	4.2	12.0	-3.5	-0.4	-0.9	1.8	3.2	1.5	0.7
Miserableness	0.2	0.3	0.7	0.2	-0.0	0.5	0.8	-0.3	0.8	0.6
Guilty feelings	0.6	0.8	1.7	1.1	1.1	1.1	0.6	-1.3	0.3	0.4
Wears glasses or contact lenses	5.6	6.4	9.1	-2.5	2.6	1.8	3.0	2.1	2.6	2.9
Ever taken oral contraceptive pill	0.4	0.5	1.4	-0.5	-1.2	-1.0	-0.6	-0.2	-0.5	-0.3
Hearing aid user	2.1	2.3	3.9	-2.0	1.1	0.7	1.8	1.3	1.6	1.9
Mother’s age at death	0.2	0.3	0.5	-0.5	0.7	0.4	0.7	0.5	-0.5	0.3
Financial situation satisfaction	0.6	0.8	3.2	1.8	0.4	0.9	-0.2	-1.1	0.1	-0.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.4	-1.1	-0.5	-0.3	0.7	1.2	0.8	0.2
Commuting to job workplace: Public transport	0.3	0.3	1.2	-0.7	-0.2	0.1	0.1	1.1	0.5	0.1
Eye problems/disorders: Glaucoma	0.6	0.7	1.4	-0.6	-0.9	-1.2	-0.8	0.9	-0.8	-0.6
Medication: Blood pressure	1.1	2.1	7.9	2.8	0.6	1.4	-0.9	-2.0	0.0	-0.2
Pain type(s) experienced in last month: Hip pain	0.7	0.9	3.2	1.4	0.0	-0.0	-0.7	-1.8	-0.5	-0.4
Supplements: Fish oil (including cod liver oil)	1.1	1.5	4.7	2.2	0.0	0.8	-0.3	-2.2	0.3	-0.3
High cholesterol (Self-reported)	0.3	0.5	1.2	1.0	0.7	1.1	-0.6	-0.4	-0.3	0.6
Medication: Bendroflumethiazide	1.1	1.6	2.6	1.6	-1.2	-0.4	-1.6	-1.5	-1.2	-1.1
Medication: Paracetamol	2.0	3.1	11.4	3.4	0.2	1.2	-1.0	-2.5	-0.7	-1.1
Medication: Lisinopril	1.4	1.8	3.4	1.8	-0.7	-0.4	-1.8	-1.7	-1.4	-0.8
Medication: Atorvastatin	1.0	1.2	2.5	1.6	1.3	1.3	-0.5	-1.1	-0.5	0.7
Illnesses of father: High blood pressure	1.1	1.4	2.4	1.6	-0.9	-0.6	-1.1	-1.2	-1.3	-1.4
Alcohol drinker status: Never	0.8	0.9	3.5	1.0	-0.6	-0.7	-0.4	-1.9	-0.6	-0.8
Ever smoked	1.3	2.3	6.7	2.6	0.3	0.4	-1.2	-2.2	-1.1	-1.3
Basal metabolic rate	3.3	18.2	46.7	6.8	-1.1	0.6	-4.1	-6.1	-3.7	-3.4
Leg fat percentage (left)	0.8	3.0	8.4	2.9	-0.5	0.1	-2.0	-2.3	-1.4	-1.2
Arm fat-free mass (left)	3.3	17.0	47.1	6.9	-0.8	1.0	-3.8	-6.0	-3.4	-3.0
Number of operations (self-reported)	0.3	0.5	1.3	0.3	-1.1	-0.6	-0.6	0.0	-0.8	-0.9
Average weekly beer plus cider intake	0.8	1.2	4.5	2.1	0.1	1.2	-0.8	-1.4	-0.0	-0.1
Irritability	0.1	0.2	0.6	0.6	-0.0	0.2	0.3	-0.7	0.8	-0.1
Risk taking	0.1	0.1	0.2	0.1	0.4	0.3	-0.5	0.0	-0.1	0.3
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.2	0.3	0.9	1.5	0.9	-0.6	0.4	1.4
Fractured/broken bones in last 5 years	2.6	3.3	6.0	2.4	-1.1	-0.6	-2.4	-1.1	-1.9	-2.3
Age started oral contraceptive pill	6.7	8.3	16.6	-4.1	0.9	0.6	2.7	3.9	3.1	2.9
Diastolic blood pressure, automated reading	1.6	5.0	14.4	3.8	-0.3	0.3	-1.8	-2.9	-1.8	-2.3
Ever depressed for a whole week	0.2	0.3	0.8	-0.4	0.3	-0.3	-0.9	-0.2	-0.7	0.2
Unable to work because of sickness or disability	0.1	0.2	0.5	0.1	-0.1	-0.7	-0.2	0.1	-0.4	-0.7
Commuting to job workplace: Cycle	1.5	1.8	5.2	-2.1	0.0	-0.2	0.9	2.3	1.2	0.6
Myopia	1.1	1.5	5.4	-0.2	2.3	1.1	1.7	0.1	0.3	1.0
Vascular/heart problems diagnosed by doctor	1.7	4.7	13.3	-3.6	-1.1	-1.4	1.5	3.6	1.1	0.1
Cholesterol lowering medication	0.2	0.4	0.9	0.0	0.8	0.9	-0.2	0.6	0.3	0.8
Medication: Omeprazole (e.g. Zanprol)	3.0	3.7	8.0	2.8	-1.7	-0.4	-1.6	-2.8	-1.3	-1.6
Pain experienced in last month	4.4	7.3	22.9	-4.8	-0.2	-1.0	2.2	4.2	1.5	1.5
Supplements: Calcium	0.4	0.5	1.2	-0.1	1.1	0.7	0.6	-0.2	0.7	0.9
Basal cell carcinoma (self-reported)	0.2	0.3	0.8	0.2	0.9	0.6	0.4	0.6	0.1	-0.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.9	-0.4	1.2	0.9	1.1	-0.6	0.9	1.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	0.8	-0.7	-0.2	-0.0	0.2	-0.2	-1.1
Heart disease (siblings)	2.0	2.5	6.0	1.3	1.9	2.4	0.9	-0.9	1.5	1.5
Alcohol drinker status: Previous	4.8	5.4	11.4	1.1	-1.9	-2.2	-3.2	0.0	-3.4	-2.6
Pack years of smoking	0.1	0.2	0.6	0.5	-0.6	0.1	-0.3	-0.8	0.4	0.1
Impedance of whole body	3.1	15.6	52.2	-7.2	-0.4	-2.7	2.9	6.0	1.9	1.6
Leg fat mass (left)	2.6	10.2	26.1	5.1	-1.1	0.1	-3.4	-4.3	-2.8	-2.5
Arm predicted mass (left)	3.5	17.9	50.4	7.1	-0.7	1.2	-3.8	-6.2	-3.3	-2.9