Best TWAS P=1.27e-09 · Best GWAS P=1.48e-11 conditioned to 0.00157
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CPSF3L | 0.13 | 0.03 | lasso | 3 | 0.06 | 2.7e-05 | 3.8 | 5.8 | 8.7e-09 | 0.84 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Tibial | CPSF3L | 0.08 | 0.00 | lasso | 4 | 0.00 | 8.9e-01 | 6.8 | 5.8 | 6.0e-09 | 0.94 | 0.00 | 0.93 | FALSE |
| 3 | GTEx | Artery Tibial | ACAP3 | 0.08 | 0.03 | lasso | 2 | 0.03 | 2.5e-03 | 3.8 | -5.4 | 6.7e-08 | -0.66 | 0.02 | 0.77 | FALSE |
| 4 | GTEx | Esophagus Mucosa | SDF4 | 0.05 | 0.00 | enet | 12 | 0.00 | 1.5e-01 | 2.9 | -5.7 | 1.5e-08 | -0.62 | 0.04 | 0.64 | FALSE |
| 5 | GTEx | Testis | PUSL1 | 0.19 | 0.02 | lasso | 6 | 0.05 | 3.8e-03 | 6.6 | -6.0 | 1.5e-09 | -0.74 | 0.01 | 0.84 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | PUSL1 | 0.10 | 0.06 | lasso | 3 | 0.06 | 9.9e-08 | 5.4 | -6.1 | 1.3e-09 | -0.80 | 0.02 | 0.98 | TRUE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | MRPL20 | 0.16 | 0.15 | enet | 9 | 0.16 | 7.4e-20 | 5.4 | 5.5 | 4.7e-08 | 0.70 | 0.84 | 0.16 | FALSE |