Best TWAS P=1.57e-08 · Best GWAS P=9.9e-12 conditioned to 0.000103
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Atrial Appendage | CCDC53 | 0.13 | 0.08 | enet | 21 | 0.09 | 0.00011 | 4.5 | -5.4 | 7.2e-08 | -0.59 | 0.18 | 0.41 | FALSE |
| 2 | The Cancer Genome Atlas | Esophageal Carcinoma | CCDC53 | 0.14 | 0.08 | blup | 50 | 0.08 | 0.00181 | 4.9 | -5.2 | 2.4e-07 | -0.75 | 0.02 | 0.87 | FALSE |
| 3 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | C12orf48 | 0.09 | 0.08 | lasso | 4 | 0.07 | 0.00035 | 5.1 | 5.4 | 6.1e-08 | 0.84 | 0.01 | 0.94 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C12orf48 | 0.03 | 0.03 | blup | 62 | 0.02 | 0.00068 | 4.7 | 5.7 | 1.6e-08 | 0.75 | 0.04 | 0.56 | TRUE |