Best TWAS P=1.94e-09 · Best GWAS P=7.47e-11 conditioned to 0.000843
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | UTP15 | 0.11 | 0.05 | lasso | 3 | 0.05 | 8.8e-05 | -4.9 | -5.3 | 1.4e-07 | -0.25 | 0.82 | 0.10 | FALSE |
2 | GTEx | Artery Tibial | UTP15 | 0.15 | 0.06 | lasso | 5 | 0.06 | 1.0e-05 | -5.1 | -5.8 | 7.5e-09 | -0.28 | 0.71 | 0.23 | TRUE |
3 | METSIM | Adipose | UTP15 | 0.09 | 0.05 | lasso | 14 | 0.06 | 2.7e-09 | -5.2 | -5.2 | 2.2e-07 | -0.29 | 0.90 | 0.10 | FALSE |
4 | ROSMAP | Brain Pre-frontal Cortex | UTP15 | 0.06 | 0.02 | lasso | 9 | 0.03 | 4.9e-05 | 4.2 | -5.3 | 9.3e-08 | -0.30 | 0.95 | 0.03 | FALSE |
5 | YFS | Blood | UTP15 | 0.06 | 0.04 | lasso | 5 | 0.06 | 2.6e-19 | 4.3 | 5.2 | 2.0e-07 | 0.26 | 0.96 | 0.04 | FALSE |
6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ANKRA2 | 0.06 | 0.04 | blup | 74 | 0.03 | 5.6e-03 | 4.4 | -5.9 | 4.5e-09 | -0.28 | 0.02 | 0.84 | FALSE |
7 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | RGNEF | 0.15 | 0.09 | lasso | 7 | 0.07 | 7.8e-04 | -5.0 | 5.1 | 2.9e-07 | 0.32 | 0.23 | 0.10 | FALSE |
8 | The Cancer Genome Atlas | Rectum Adenocarcinoma | ANKRA2 | 0.23 | 0.14 | lasso | 4 | 0.10 | 2.3e-03 | 5.8 | -6.0 | 2.5e-09 | -0.31 | 0.01 | 0.88 | FALSE |
9 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | RGNEF | 0.18 | 0.00 | blup | 254 | 0.08 | 3.7e-03 | 2.6 | 6.0 | 1.9e-09 | 0.64 | 0.07 | 0.31 | TRUE |