TWAS hub - Hearing aid user

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	53989244	55590761	1	1	3.2e-08	3.8e-07	0.06230	86	SPTBN1
2	5	72162264	73576479	3	2	1.9e-09	7.5e-11	0.00084	74	RGNEF UTP15

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Hearing difficulty/problems: Yes	20.70	3	2	4.4	1	RGNEF SPTBN1 UTP15
Hearing difficulty/problems with background noise	12.05	3	1	2.2	1	RGNEF SPTBN1 UTP15
Commuting to job workplace: Cycle	5.24	1	0	0.0	1	SPTBN1
Medication: Seretide 50 evohaler	5.12	1	0	0.0	1	RGNEF
Birth weight of first child	3.56	1	0	0.0	1	UTP15
Neuroticism (2016)	3.00	1	0	0.0	1	UTP15
Had major operations	2.98	1	0	0.0	1	SPTBN1
Wheeze or whistling in the chest in last year	2.31	1	0	0.0	1	RGNEF
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.15	1	0	0.0	1	RGNEF
Number of live births	2.09	1	0	0.0	1	SPTBN1
Medication: Blood pressure	2.04	1	0	0.0	1	RGNEF
Forced expiratory volume in 1-second (FEV1), Best measure	2.01	1	0	0.0	1	SPTBN1
Peak expiratory flow (PEF)	1.71	1	0	0.0	1	RGNEF
Vascular/heart problems diagnosed by doctor	1.69	1	0	0.0	1	RGNEF
Forced vital capacity (FVC), Best measure	1.66	1	0	0.0	1	RGNEF
Lung FEV1/FVC ratio	1.64	1	0	0.0	1	SPTBN1
High blood pressure	1.56	1	0	0.0	1	RGNEF
Leg fat mass (left)	1.47	1	0	0.0	1	RGNEF
Cardiovascular Disease	1.39	1	0	0.0	1	RGNEF
Forced vital capacity (FVC)	1.33	1	0	0.0	1	RGNEF
Weight	1.32	1	0	0.0	1	RGNEF
Comparative body size at age 10	1.30	1	0	0.0	1	RGNEF
Heel T-Score	1.27	1	0	0.0	1	SPTBN1
Hypertension (Self-reported)	1.27	1	0	0.0	1	RGNEF
BMI	1.18	1	0	0.0	1	RGNEF
Trunk fat mass	1.16	1	0	0.0	1	RGNEF
Blood Eosinophil Count	1.13	1	0	0.0	1	RGNEF
Basal metabolic rate	0.94	1	0	0.0	1	RGNEF
Leg fat-free mass (left)	0.93	1	0	0.0	1	RGNEF
Leg fat-free mass (right)	0.93	1	0	0.0	1	RGNEF
Arm predicted mass (right)	0.92	1	0	0.0	1	RGNEF
Leg predicted mass (right)	0.92	1	0	0.0	1	RGNEF
Leg predicted mass (left)	0.90	1	0	0.0	1	RGNEF
Lung FVC	0.87	1	0	0.0	1	RGNEF
Hair Pigment	0.43	2	0	0.0	1	SPTBN1 UTP15
Height	0.31	1	0	0.0	1	SPTBN1

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	2	0.057	1.2
GTEx	Artery Aorta	1	0.034	1.2
GTEx	Artery Tibial	1	0.027	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Frontal Cortex BA9	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Small Intestine Terminal Ileum	0	0.000	1.2
GTEx	Testis	0	0.000	1.2
GTEx	Uterus	0	0.000	1.2
GTEx	Vagina	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
NTR	Blood	0	0.000	1.2
YFS	Blood	1	0.022	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	1	0.145	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
GTEx	Adipose Visceral Omentum	0	0.000	1.1
GTEx	Adrenal Gland	0	0.000	1.1
GTEx	Artery Coronary	0	0.000	1.1
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.1
GTEx	Brain Cerebellum	0	0.000	1.1
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.1
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.1
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.1
GTEx	Colon Transverse	0	0.000	1.1
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.1
GTEx	Esophagus Mucosa	0	0.000	1.1
GTEx	Esophagus Muscularis	0	0.000	1.1
GTEx	Heart Atrial Appendage	0	0.000	1.1
GTEx	Heart Left Ventricle	0	0.000	1.1
GTEx	Liver	0	0.000	1.1
GTEx	Muscle Skeletal	0	0.000	1.1
GTEx	Nerve Tibial	0	0.000	1.1
GTEx	Pituitary	0	0.000	1.1
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.1
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.1
GTEx	Spleen	0	0.000	1.1
GTEx	Stomach	0	0.000	1.1
GTEx	Thyroid	0	0.000	1.1
METSIM	Adipose	1	0.022	1.1
ROSMAP	Brain Pre-frontal Cortex	1	0.023	1.1
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.1
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.1
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.1
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.1
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.187	1.1
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.1

Hub : Traits :

Hearing aid user

Significant Loci

Pleiotropic Associations

Associations by panel