Hub : Traits :

Hearing aid user

12 significantly associated models · 4 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 53989244 55590761 1 1 3.2e-08 3.8e-07 0.06230 86 SPTBN1
2 5 72162264 73576479 3 2 1.9e-09 7.5e-11 0.00084 74 RGNEF UTP15

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Neuroticism (2016) 3.00 1 0 0.0 0 1 UTP15
Blood Eosinophil Count 1.13 1 0 0.0 0 1 RGNEF
Heel T-Score 1.27 1 0 0.0 0 1 SPTBN1
BMI 1.18 1 0 0.0 0 1 RGNEF
Height 0.31 1 0 0.0 0 1 SPTBN1
Cardiovascular Disease 1.39 1 0 0.0 0 1 RGNEF
Lung FEV1/FVC ratio 1.64 1 0 0.0 0 1 SPTBN1
Lung FVC 0.87 1 0 0.0 0 1 RGNEF
Hair Pigment 0.43 2 0 0.0 0 1 SPTBN1 UTP15
Hearing difficulty/problems: Yes 20.70 3 2 4.4 0 1 RGNEF SPTBN1 UTP15
Leg fat-free mass (left) 0.93 1 0 0.0 0 1 RGNEF
High blood pressure 1.56 1 0 0.0 0 1 RGNEF
Leg predicted mass (left) 0.90 1 0 0.0 0 1 RGNEF
Trunk fat mass 1.16 1 0 0.0 0 1 RGNEF
Hearing difficulty/problems with background noise 12.05 3 1 2.2 0 1 RGNEF SPTBN1 UTP15
Forced vital capacity (FVC) 1.33 1 0 0.0 0 1 RGNEF
Weight 1.32 1 0 0.0 0 1 RGNEF
Number of live births 2.09 1 0 0.0 0 1 SPTBN1
Forced expiratory volume in 1-second (FEV1), Best measure 2.01 1 0 0.0 0 1 SPTBN1
Birth weight of first child 3.56 1 0 0.0 0 1 UTP15
Peak expiratory flow (PEF) 1.71 1 0 0.0 0 1 RGNEF
Forced vital capacity (FVC), Best measure 1.66 1 0 0.0 0 1 RGNEF
Comparative body size at age 10 1.30 1 0 0.0 0 1 RGNEF
Wheeze or whistling in the chest in last year 2.31 1 0 0.0 0 1 RGNEF
Medication: Blood pressure 2.04 1 0 0.0 0 1 RGNEF
Medication: Seretide 50 evohaler 5.12 1 0 0.0 0 1 RGNEF
Arm predicted mass (right) 0.92 1 0 0.0 0 1 RGNEF
Had major operations 2.98 1 0 0.0 0 1 SPTBN1
Hypertension (Self-reported) 1.27 1 0 0.0 0 1 RGNEF
Leg fat-free mass (right) 0.93 1 0 0.0 0 1 RGNEF
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.15 1 0 0.0 0 1 RGNEF
Leg predicted mass (right) 0.92 1 0 0.0 0 1 RGNEF
Basal metabolic rate 0.94 1 0 0.0 0 1 RGNEF
Commuting to job workplace: Cycle 5.24 1 0 0.0 0 1 SPTBN1
Vascular/heart problems diagnosed by doctor 1.69 1 0 0.0 0 1 RGNEF
Leg fat mass (left) 1.47 1 0 0.0 0 1 RGNEF

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.057 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.1
GTEx Adrenal Gland 0 0.000 1.1
GTEx Artery Aorta 1 0.034 1.2
GTEx Artery Coronary 0 0.000 1.1
GTEx Artery Tibial 1 0.027 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.1
GTEx Brain Cerebellum 0 0.000 1.1
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.1
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.1
GTEx Breast Mammary Tissue (Female) 0 0.000 1.1
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.1
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.1
GTEx Esophagus Mucosa 0 0.000 1.1
GTEx Esophagus Muscularis 0 0.000 1.1
GTEx Heart Atrial Appendage 0 0.000 1.1
GTEx Heart Left Ventricle 0 0.000 1.1
GTEx Liver 0 0.000 1.1
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.1
GTEx Nerve Tibial 0 0.000 1.1
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.1
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.1
GTEx Skin Sun Exposed Lower leg 0 0.000 1.1
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.1
GTEx Stomach 0 0.000 1.1
GTEx Testis 0 0.000 1.2
GTEx Thyroid 0 0.000 1.1
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 1 0.022 1.1
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 1 0.023 1.1
YFS Blood 1 0.022 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.1
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.1
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 1 0.063 1.1
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.075 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Rectum Adenocarcinoma 1 0.145 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.1
The Cancer Genome Atlas Skin Cutaneous Melanoma 1 0.187 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.1