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chr17:42,413,481-43,570,226

Best TWAS P=1.64e-12 · Best GWAS P=1.39e-11 conditioned to 0.267

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DCAKD	0.18	0.20	lasso	6	0.20	2.6e-23	5.1	-5.2	1.8e-07	-0.76	0.87	0.13	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NMT1	0.07	0.05	bslmm	323	0.05	1.5e-06	4.2	6.2	5.1e-10	0.79	0.02	0.98	FALSE
3	GTEx	Artery Aorta	NMT1	0.14	0.08	lasso	2	0.12	3.9e-07	6.8	6.5	6.2e-11	0.94	0.00	1.00	FALSE
4	GTEx	Artery Tibial	NMT1	0.11	0.09	lasso	5	0.10	6.3e-08	6.8	6.0	1.8e-09	0.94	0.00	1.00	FALSE
5	GTEx	Breast Mammary Tissue	DCAKD	0.16	0.13	lasso	7	0.13	2.9e-07	6.2	-6.2	6.1e-10	-0.77	0.08	0.92	FALSE
6	GTEx	Breast Mammary Tissue (Male)	DCAKD	0.36	0.29	lasso	8	0.33	1.4e-08	5.1	-6.0	2.4e-09	-0.75	0.03	0.96	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	HEXIM1	0.20	0.00	enet	25	0.02	6.9e-02	5.8	-6.3	3.0e-10	-0.65	0.02	0.78	FALSE
8	GTEx	Colon Sigmoid	DCAKD	0.18	0.16	lasso	3	0.16	2.1e-06	5.1	-5.2	2.5e-07	-0.80	0.18	0.75	FALSE
9	GTEx	Colon Transverse	DCAKD	0.28	0.18	lasso	8	0.26	1.5e-12	5.1	-5.2	2.5e-07	-0.85	0.09	0.91	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	NMT1	0.24	0.21	lasso	4	0.22	2.8e-08	-5.0	6.2	5.1e-10	0.80	0.02	0.97	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	DCAKD	0.42	0.36	lasso	7	0.37	3.8e-14	6.2	-6.0	1.6e-09	-0.76	0.12	0.88	FALSE
12	GTEx	Esophagus Mucosa	DCAKD	0.33	0.32	enet	20	0.35	5.6e-24	5.1	-5.1	3.1e-07	-0.79	0.88	0.12	FALSE
13	GTEx	Esophagus Muscularis	NMT1	0.13	0.12	lasso	2	0.14	1.5e-08	-5.0	6.2	6.1e-10	0.93	0.01	0.99	FALSE
14	GTEx	Esophagus Muscularis	DCAKD	0.27	0.29	lasso	5	0.30	2.1e-18	5.1	-5.3	1.1e-07	-0.79	0.96	0.04	FALSE
15	GTEx	Heart Left Ventricle	DCAKD	0.17	0.17	lasso	3	0.17	2.3e-09	5.1	-5.6	2.1e-08	-0.78	0.20	0.80	FALSE
16	GTEx	Muscle Skeletal	DCAKD	0.12	0.06	enet	16	0.07	9.9e-08	6.2	-6.5	8.5e-11	-0.80	0.07	0.93	FALSE
17	GTEx	Nerve Tibial	NMT1	0.16	0.14	lasso	6	0.11	2.0e-08	-5.0	5.4	6.2e-08	0.83	0.09	0.91	FALSE
18	GTEx	Nerve Tibial	DCAKD	0.35	0.29	enet	21	0.30	1.6e-21	-5.7	-5.7	1.2e-08	-0.86	0.31	0.69	FALSE
19	GTEx	Pancreas	NMT1	0.19	0.12	enet	18	0.07	8.0e-04	6.8	6.0	1.7e-09	0.85	0.00	0.99	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	DCAKD	0.30	0.21	lasso	6	0.20	5.0e-11	6.2	-5.9	2.7e-09	-0.75	0.09	0.91	FALSE
21	GTEx	Thyroid	DCAKD	0.25	0.26	enet	17	0.27	9.4e-21	6.2	-6.4	1.5e-10	-0.82	0.09	0.91	FALSE
22	GTEx	Whole Blood	DCAKD	0.07	0.08	lasso	2	0.06	1.8e-06	5.1	-5.3	9.2e-08	-0.74	0.23	0.76	FALSE
23	METSIM	Adipose	NMT1	0.13	0.11	lasso	6	0.11	5.7e-16	6.2	6.2	6.2e-10	0.86	0.04	0.96	FALSE
24	NTR	Blood	DCAKD	0.02	0.01	enet	5	0.01	5.0e-05	-5.7	-5.9	4.5e-09	-0.87	0.04	0.96	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	DCAKD	0.26	0.18	enet	27	0.24	8.8e-31	5.1	-5.3	1.4e-07	-0.65	0.58	0.42	FALSE
26	YFS	Blood	NMT1	0.02	0.01	lasso	6	0.01	5.0e-03	-2.6	5.5	3.3e-08	0.81	0.00	0.98	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	DCAKD	0.04	0.02	lasso	4	0.02	6.3e-06	6.2	-5.7	1.0e-08	-0.71	0.11	0.89	FALSE
28	The Cancer Genome Atlas	Esophageal Carcinoma	LOC644172	0.19	0.12	lasso	3	0.05	8.2e-03	6.4	-5.8	8.5e-09	-0.80	0.01	0.76	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DCAKD	0.07	0.07	lasso	4	0.07	1.4e-08	6.2	-5.7	1.6e-08	-0.72	0.08	0.92	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DCAKD	0.03	0.04	lasso	2	0.03	3.8e-04	6.0	-6.1	9.5e-10	-0.85	0.05	0.88	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NMT1	0.05	0.04	lasso	2	0.04	1.5e-05	6.8	6.8	9.6e-12	1.00	0.00	1.00	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	NMT1	0.08	0.04	blup	83	0.05	3.5e-06	5.1	5.4	6.2e-08	0.79	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	DCAKD	0.03	0.03	lasso	3	0.04	3.2e-05	-4.6	-5.2	2.4e-07	-0.82	0.08	0.84	FALSE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	NMT1	0.04	0.00	blup	81	0.01	1.9e-02	6.8	5.3	1.1e-07	0.85	0.00	0.93	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DCAKD	0.04	0.02	blup	66	0.02	3.5e-03	6.4	-5.1	2.9e-07	-0.68	0.04	0.89	FALSE
36	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NMT1	0.23	0.08	blup	82	0.12	1.1e-05	-5.7	6.5	7.1e-11	0.82	0.00	0.99	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	ACBD4	0.04	0.01	enet	7	0.03	2.2e-04	-2.5	5.6	2.2e-08	0.71	0.02	0.76	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	NMT1	0.09	0.08	lasso	3	0.09	1.1e-09	-5.7	6.6	4.1e-11	0.96	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	DCAKD	0.12	0.13	lasso	8	0.13	5.5e-13	5.1	-5.7	1.4e-08	-0.81	0.20	0.80	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	HEXIM1	0.05	0.05	blup	47	0.04	8.5e-05	4.2	-5.5	3.5e-08	-0.66	0.16	0.77	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	NMT1	0.18	0.19	enet	20	0.20	3.8e-19	6.8	7.1	1.6e-12	0.88	0.00	1.00	TRUE