Best TWAS P=6.41e-08 · Best GWAS P=1.64e-19 conditioned to 4.78e-21
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | MANBA | 0.26 | 0.22 | lasso | 9 | 0.27 | 1.9e-20 | -4.9 | -5.4 | 6.4e-08 | -0.07 | 1.00 | 0.00 | TRUE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | MANBA | 0.20 | 0.30 | enet | 26 | 0.31 | 2.3e-40 | -5.5 | 5.4 | 8.1e-08 | 0.09 | 1.00 | 0.00 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MANBA | 0.11 | 0.16 | lasso | 4 | 0.16 | 3.4e-32 | -5.0 | -5.3 | 1.1e-07 | -0.07 | 0.00 | 0.99 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MANBA | 0.07 | 0.04 | blup | 73 | 0.03 | 2.2e-04 | -5.1 | -5.3 | 1.1e-07 | -0.03 | 0.01 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MANBA | 0.11 | 0.04 | lasso | 7 | 0.04 | 3.5e-05 | -5.0 | -5.2 | 2.0e-07 | -0.06 | 0.01 | 0.99 | FALSE |