TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Diastolic blood pressure, automated reading
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chr4:102,868,793-104,374,596
Best TWAS P=6.41e-08 · Best GWAS P=1.64e-19 conditioned to 4.78e-21
102.8M
103M
103.2M
103.4M
103.6M
103.8M
104M
104.2M
104.4M
0
5
10
15
20
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Cells Transformed fibroblasts
MANBA
0.26
0.22
lasso
9
0.27
1.9e-20
-4.9
-5.4
6.4e-08
-0.07
1.00
0.00
TRUE
2
ROSMAP
Brain Pre-frontal Cortex
MANBA
0.20
0.30
enet
26
0.31
2.3e-40
-5.5
5.4
8.1e-08
0.09
1.00
0.00
FALSE
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
MANBA
0.11
0.16
lasso
4
0.16
3.4e-32
-5.0
-5.3
1.1e-07
-0.07
0.00
0.99
FALSE
4
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
MANBA
0.07
0.04
blup
73
0.03
2.2e-04
-5.1
-5.3
1.1e-07
-0.03
0.01
0.98
FALSE
5
The Cancer Genome Atlas
Prostate Adenocarcinoma
MANBA
0.11
0.04
lasso
7
0.04
3.5e-05
-5.0
-5.2
2.0e-07
-0.06
0.01
0.99
FALSE