Best TWAS P=2.82e-12 · Best GWAS P=1.69e-12 conditioned to 0.0872
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | IRAK1BP1 | 0.12 | 0.10 | lasso | 4 | 0.15 | 2.7e-12 | 6.6 | 6.1 | 8.0e-10 | 0.90 | 0.05 | 0.95 | FALSE |
2 | GTEx | Adipose Visceral Omentum | IRAK1BP1 | 0.17 | 0.16 | enet | 20 | 0.19 | 2.5e-10 | 6.7 | 6.0 | 2.1e-09 | 0.79 | 0.11 | 0.89 | FALSE |
3 | GTEx | Adrenal Gland | IRAK1BP1 | 0.33 | 0.40 | enet | 31 | 0.40 | 1.5e-15 | 6.6 | 6.6 | 5.1e-11 | 0.76 | 0.12 | 0.88 | FALSE |
4 | GTEx | Artery Aorta | IRAK1BP1 | 0.17 | 0.15 | lasso | 1 | 0.11 | 1.6e-06 | 6.7 | 6.7 | 2.9e-11 | 0.79 | 0.11 | 0.89 | FALSE |
5 | GTEx | Artery Coronary | IRAK1BP1 | 0.11 | -0.01 | lasso | 3 | 0.01 | 1.8e-01 | 6.6 | 5.8 | 8.7e-09 | 0.66 | 0.09 | 0.61 | FALSE |
6 | GTEx | Artery Coronary | PHIP | 0.17 | 0.02 | lasso | 5 | 0.02 | 8.5e-02 | 5.1 | 6.1 | 1.4e-09 | 0.80 | 0.09 | 0.72 | FALSE |
7 | GTEx | Artery Tibial | IRAK1BP1 | 0.11 | 0.15 | lasso | 4 | 0.16 | 1.4e-12 | 6.7 | 6.3 | 2.2e-10 | 0.82 | 0.11 | 0.89 | FALSE |
8 | GTEx | Brain Caudate basal ganglia | IRAK1BP1 | 0.11 | 0.12 | enet | 7 | 0.09 | 1.3e-03 | -5.4 | 5.2 | 1.7e-07 | 0.71 | 0.09 | 0.57 | FALSE |
9 | GTEx | Brain Nucleus accumbens basal ganglia | IRAK1BP1 | 0.11 | 0.08 | lasso | 10 | 0.07 | 6.0e-03 | 6.7 | -6.8 | 1.3e-11 | -0.79 | 0.10 | 0.64 | FALSE |
10 | GTEx | Breast Mammary Tissue | IRAK1BP1 | 0.09 | 0.07 | enet | 10 | 0.07 | 1.1e-04 | 6.6 | 6.2 | 5.1e-10 | 0.67 | 0.12 | 0.82 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | BCKDHB | 0.16 | 0.02 | enet | 42 | 0.04 | 3.7e-04 | -2.8 | -5.5 | 4.7e-08 | 0.03 | 0.27 | 0.57 | TRUE |
12 | GTEx | Cells Transformed fibroblasts | IRAK1BP1 | 0.25 | 0.35 | enet | 30 | 0.36 | 3.5e-28 | 6.6 | 6.0 | 1.7e-09 | 0.80 | 0.12 | 0.88 | FALSE |
13 | GTEx | Colon Sigmoid | IRAK1BP1 | 0.19 | 0.20 | lasso | 2 | 0.17 | 1.0e-06 | 6.6 | 6.6 | 3.2e-11 | 0.79 | 0.12 | 0.88 | FALSE |
14 | GTEx | Esophagus Gastroesophageal Junction | IRAK1BP1 | 0.18 | 0.18 | enet | 34 | 0.18 | 4.7e-07 | 6.7 | 6.0 | 1.9e-09 | 0.76 | 0.12 | 0.88 | FALSE |
15 | GTEx | Esophagus Muscularis | IRAK1BP1 | 0.17 | 0.22 | lasso | 4 | 0.22 | 1.6e-13 | 6.6 | 6.1 | 1.1e-09 | 0.74 | 0.12 | 0.88 | FALSE |
16 | GTEx | Esophagus Muscularis | PHIP | 0.08 | 0.04 | enet | 15 | 0.02 | 3.6e-02 | 6.4 | 5.2 | 2.2e-07 | 0.66 | 0.11 | 0.79 | FALSE |
17 | GTEx | Heart Atrial Appendage | IRAK1BP1 | 0.15 | 0.14 | lasso | 2 | 0.12 | 4.6e-06 | 6.7 | 6.0 | 1.5e-09 | 0.67 | 0.11 | 0.86 | FALSE |
18 | GTEx | Heart Atrial Appendage | RP11-250B2.6 | 0.20 | 0.00 | enet | 17 | 0.03 | 2.6e-02 | 2.2 | 5.4 | 6.3e-08 | -0.06 | 0.04 | 0.58 | FALSE |
19 | GTEx | Heart Left Ventricle | IRAK1BP1 | 0.17 | 0.20 | lasso | 5 | 0.20 | 8.7e-11 | 6.6 | 6.6 | 5.6e-11 | 0.79 | 0.12 | 0.88 | FALSE |
20 | GTEx | Lung | IRAK1BP1 | 0.14 | 0.18 | lasso | 5 | 0.17 | 3.9e-13 | 6.6 | 6.6 | 3.6e-11 | 0.82 | 0.12 | 0.88 | FALSE |
21 | GTEx | Muscle Skeletal | IRAK1BP1 | 0.10 | 0.11 | lasso | 2 | 0.10 | 1.3e-09 | 6.6 | 6.7 | 1.7e-11 | 0.79 | 0.11 | 0.89 | FALSE |
22 | GTEx | Nerve Tibial | IRAK1BP1 | 0.12 | 0.16 | lasso | 6 | 0.14 | 8.8e-10 | -3.8 | 5.1 | 2.7e-07 | 0.73 | 0.14 | 0.86 | TRUE |
23 | GTEx | Ovary | IRAK1BP1 | 0.13 | 0.15 | lasso | 2 | 0.06 | 1.2e-02 | 6.6 | 6.6 | 5.4e-11 | 0.79 | 0.09 | 0.75 | FALSE |
24 | GTEx | Pancreas | IRAK1BP1 | 0.24 | 0.23 | lasso | 8 | 0.25 | 6.1e-11 | 6.6 | 6.3 | 4.1e-10 | 0.87 | 0.09 | 0.91 | FALSE |
25 | GTEx | Prostate | IRAK1BP1 | 0.15 | 0.08 | enet | 7 | 0.09 | 2.4e-03 | 6.7 | 6.4 | 1.9e-10 | 0.88 | 0.05 | 0.85 | FALSE |
26 | GTEx | Stomach | IRAK1BP1 | 0.18 | 0.14 | enet | 32 | 0.14 | 2.6e-07 | 6.7 | 5.7 | 9.1e-09 | 0.72 | 0.12 | 0.88 | FALSE |
27 | GTEx | Testis | IRAK1BP1 | 0.39 | 0.56 | lasso | 11 | 0.58 | 7.7e-31 | 6.6 | 6.7 | 2.8e-11 | 0.79 | 0.11 | 0.89 | FALSE |
28 | GTEx | Thyroid | IRAK1BP1 | 0.09 | 0.12 | lasso | 9 | 0.11 | 5.2e-09 | 6.6 | 7.0 | 2.8e-12 | 0.85 | 0.11 | 0.89 | TRUE |