Best TWAS P=3.81e-09 · Best GWAS P=2.59e-08 conditioned to 0.48
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C1GALT1 | 0.26 | 0.15 | enet | 20 | 0.23 | 1.1e-27 | 4.0 | 5.3 | 1.4e-07 | 0.67 | 0.33 | 0.66 | FALSE |
2 | GTEx | Brain Caudate basal ganglia | C1GALT1 | 0.27 | 0.18 | enet | 8 | 0.20 | 2.4e-06 | 4.9 | 5.5 | 4.4e-08 | 0.80 | 0.03 | 0.94 | FALSE |
3 | GTEx | Brain Nucleus accumbens basal ganglia | C1GALT1 | 0.28 | 0.00 | enet | 28 | 0.01 | 1.8e-01 | 4.9 | 5.6 | 2.3e-08 | 0.69 | 0.03 | 0.77 | FALSE |
4 | GTEx | Colon Sigmoid | C1GALT1 | 0.52 | 0.25 | enet | 38 | 0.31 | 1.0e-11 | 4.9 | 5.7 | 1.6e-08 | 0.67 | 0.05 | 0.95 | FALSE |
5 | GTEx | Colon Transverse | C1GALT1 | 0.32 | 0.23 | lasso | 4 | 0.30 | 8.0e-15 | 5.3 | 5.9 | 3.8e-09 | 0.89 | 0.01 | 0.99 | TRUE |
6 | GTEx | Esophagus Mucosa | C1GALT1 | 0.33 | 0.19 | lasso | 6 | 0.18 | 2.8e-12 | 5.5 | 5.9 | 4.2e-09 | 0.89 | 0.00 | 0.99 | FALSE |
7 | GTEx | Esophagus Muscularis | C1GALT1 | 0.36 | 0.16 | lasso | 8 | 0.27 | 1.9e-16 | 4.9 | 5.9 | 4.0e-09 | 0.83 | 0.03 | 0.97 | FALSE |
8 | GTEx | Lung | C1GALT1 | 0.18 | 0.13 | lasso | 3 | 0.15 | 1.1e-11 | 4.9 | 5.8 | 8.0e-09 | 0.75 | 0.08 | 0.92 | FALSE |
9 | GTEx | Nerve Tibial | C1GALT1 | 0.44 | 0.28 | lasso | 12 | 0.40 | 2.0e-30 | 4.2 | 5.7 | 1.2e-08 | 0.82 | 0.07 | 0.92 | FALSE |
10 | GTEx | Ovary | C1GALT1 | 0.22 | 0.14 | enet | 11 | 0.15 | 1.8e-04 | 5.5 | 5.6 | 2.0e-08 | 0.92 | 0.01 | 0.96 | FALSE |
11 | GTEx | Pancreas | C1GALT1 | 0.44 | 0.11 | enet | 24 | 0.22 | 8.8e-10 | 4.2 | 5.8 | 4.9e-09 | 0.81 | 0.03 | 0.96 | FALSE |
12 | GTEx | Uterus | C1GALT1 | 0.38 | 0.28 | enet | 8 | 0.32 | 2.0e-07 | 5.3 | 5.5 | 5.0e-08 | 0.91 | 0.01 | 0.97 | FALSE |
13 | METSIM | Adipose | C1GALT1 | 0.22 | 0.16 | lasso | 9 | 0.23 | 5.1e-34 | 4.9 | 5.7 | 1.4e-08 | 0.76 | 0.08 | 0.92 | FALSE |
14 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C1GALT1 | 0.16 | 0.12 | lasso | 7 | 0.14 | 3.7e-08 | 5.4 | 5.5 | 2.9e-08 | 0.82 | 0.01 | 0.99 | FALSE |
15 | The Cancer Genome Atlas | Thyroid Carcinoma | C1GALT1 | 0.05 | 0.01 | lasso | 2 | 0.01 | 3.8e-02 | 4.9 | 5.2 | 1.5e-07 | 0.71 | 0.04 | 0.56 | FALSE |