Best TWAS P=2.27e-08 · Best GWAS P=8.51e-08 conditioned to 0.0215
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | PLEKHM2 | 0.27 | 0.17 | lasso | 8 | 0.16 | 5.7e-05 | -5.2 | -5.3 | 1.4e-07 | 0.94 | 0.04 | 0.94 | FALSE |
| 2 | GTEx | Brain Cerebellum | PLEKHM2 | 0.26 | 0.22 | lasso | 9 | 0.25 | 4.8e-08 | -5.3 | -5.2 | 2.3e-07 | 0.97 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Brain Cerebellum | RP11-288I21.1 | 0.27 | 0.14 | lasso | 16 | 0.13 | 1.1e-04 | -5.1 | -5.3 | 1.2e-07 | 0.96 | 0.03 | 0.94 | FALSE |
| 4 | GTEx | Esophagus Mucosa | PLEKHM2 | 0.10 | 0.01 | enet | 20 | 0.02 | 1.2e-02 | -5.3 | 5.4 | 6.5e-08 | -0.66 | 0.02 | 0.94 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | PLEKHM2 | 0.06 | 0.01 | blup | 488 | 0.03 | 4.7e-05 | -2.1 | -5.6 | 2.3e-08 | 0.64 | 0.05 | 0.85 | TRUE |