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chr1:43,073,464-44,618,031

Best TWAS P=1e-10 · Best GWAS P=8.14e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ELOVL1	0.04	0.01	enet	11	0.01	6.3e-03	5.3	-5.4	7.0e-08	-0.77	0.11	0.85	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TIE1	0.04	0.05	lasso	3	0.05	2.1e-06	5.6	-5.5	3.2e-08	-0.78	0.24	0.76	FALSE
3	GTEx	Adipose Subcutaneous	TIE1	0.10	0.05	lasso	3	0.05	4.4e-05	5.6	-5.6	2.3e-08	-0.79	0.18	0.82	FALSE
4	GTEx	Adipose Visceral Omentum	TIE1	0.13	0.09	lasso	4	0.06	7.5e-04	5.6	-5.6	2.3e-08	-0.82	0.10	0.84	FALSE
5	GTEx	Adrenal Gland	HYI	0.15	0.18	lasso	1	0.14	8.0e-06	5.6	-5.6	2.6e-08	-0.82	0.13	0.82	FALSE
6	GTEx	Breast Mammary Tissue	TIE1	0.08	0.06	lasso	5	0.08	7.1e-05	5.3	-5.8	8.8e-09	-0.87	0.04	0.94	FALSE
7	GTEx	Cells Transformed fibroblasts	RP1-92O14.6	0.12	0.02	lasso	5	0.03	3.6e-03	5.6	-5.3	8.9e-08	-0.78	0.08	0.91	FALSE
8	GTEx	Esophagus Mucosa	HYI	0.08	0.05	enet	18	0.06	4.9e-05	5.5	-5.9	3.5e-09	-0.76	0.05	0.94	FALSE
9	GTEx	Esophagus Mucosa	RP1-92O14.6	0.12	0.11	lasso	3	0.09	8.3e-07	5.7	-5.7	1.1e-08	-0.83	0.09	0.90	FALSE
10	GTEx	Heart Left Ventricle	TIE1	0.22	0.04	lasso	11	0.04	5.3e-03	5.6	-5.5	4.6e-08	-0.86	0.06	0.93	FALSE
11	GTEx	Lung	HYI	0.18	0.04	enet	22	0.06	1.8e-05	6.5	-5.4	6.0e-08	-0.78	0.01	0.99	FALSE
12	GTEx	Muscle Skeletal	TIE1	0.08	0.06	lasso	6	0.05	5.5e-06	5.5	-5.9	4.5e-09	-0.86	0.06	0.94	FALSE
13	GTEx	Muscle Skeletal	MED8	0.23	0.37	lasso	1	0.37	7.7e-38	5.7	-5.7	1.3e-08	-0.83	0.36	0.64	FALSE
14	GTEx	Muscle Skeletal	RP1-92O14.6	0.18	0.24	lasso	3	0.24	6.8e-23	5.7	-5.9	4.7e-09	-0.86	0.34	0.66	FALSE
15	GTEx	Nerve Tibial	TIE1	0.20	0.09	lasso	6	0.13	2.6e-09	5.6	-5.8	7.5e-09	-0.79	0.06	0.93	FALSE
16	GTEx	Nerve Tibial	MED8	0.13	0.07	enet	11	0.16	3.6e-11	6.1	5.5	3.5e-08	0.82	0.04	0.96	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	RP1-92O14.6	0.25	0.09	lasso	12	0.11	1.9e-06	6.1	-6.1	8.9e-10	-0.87	0.03	0.97	FALSE
18	GTEx	Skin Sun Exposed Lower leg	RP1-92O14.6	0.13	0.07	lasso	5	0.07	1.6e-06	5.5	-6.1	9.4e-10	-0.92	0.04	0.96	FALSE
19	GTEx	Testis	SZT2	0.14	0.12	lasso	3	0.09	5.7e-05	6.4	6.5	1.0e-10	0.99	0.02	0.98	TRUE
20	GTEx	Thyroid	TIE1	0.10	0.05	lasso	3	0.05	1.3e-04	5.6	-5.6	2.1e-08	-0.86	0.03	0.95	FALSE
21	GTEx	Thyroid	MED8	0.08	0.07	lasso	3	0.06	2.0e-05	5.7	5.7	1.3e-08	0.83	0.24	0.76	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	TIE1	0.08	0.10	lasso	3	0.10	1.3e-12	5.2	-5.2	1.5e-07	-0.78	0.50	0.50	FALSE
23	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1orf84	0.02	0.02	blup	44	0.01	2.0e-02	6.4	-6.0	2.2e-09	-0.93	0.02	0.71	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MED8	0.03	0.00	blup	38	0.01	2.1e-02	6.1	-5.5	4.4e-08	-0.89	0.01	0.54	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1orf84	0.02	0.03	blup	46	0.03	3.4e-07	6.1	-6.0	1.8e-09	-0.92	0.03	0.97	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	TIE1	0.01	0.02	lasso	1	0.01	1.8e-03	5.2	-5.2	2.1e-07	-0.77	0.02	0.94	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HYI	0.02	0.01	blup	34	0.02	6.1e-03	6.1	-6.2	5.9e-10	-0.96	0.02	0.78	FALSE
28	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MED8	0.02	0.03	enet	5	0.02	9.0e-04	6.4	-6.2	4.8e-10	-0.97	0.01	0.96	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KIAA0467	0.03	0.00	blup	54	0.02	2.7e-03	5.0	5.7	1.4e-08	0.82	0.02	0.48	FALSE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ELOVL1	0.06	0.04	blup	36	0.03	4.7e-03	5.7	-6.0	1.9e-09	-0.87	0.02	0.92	FALSE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	C1orf84	0.01	0.02	blup	45	0.02	3.0e-03	6.1	-6.3	3.7e-10	-0.94	0.02	0.81	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	TIE1	0.02	0.02	blup	46	0.02	9.0e-04	5.3	-5.5	4.3e-08	-0.78	0.01	0.88	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	C1orf84	0.02	0.02	blup	45	0.02	1.3e-03	5.7	-6.4	1.7e-10	-0.94	0.03	0.87	FALSE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	CDC20	0.03	0.03	blup	34	0.03	8.8e-05	5.5	-5.5	3.0e-08	-0.75	0.07	0.80	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	MED8	0.02	0.02	blup	39	0.01	7.5e-03	5.5	-5.9	2.8e-09	-0.83	0.02	0.52	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MED8	0.03	0.01	lasso	4	0.02	6.2e-03	-3.2	-5.3	1.3e-07	-0.90	0.02	0.71	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	C1orf84	0.02	0.02	lasso	2	0.02	8.8e-03	5.6	-5.6	1.7e-08	-0.83	0.03	0.53	FALSE
38	The Cancer Genome Atlas	Skin Cutaneous Melanoma	KIAA0467	0.17	0.08	blup	52	0.13	2.9e-04	5.6	6.2	4.8e-10	0.93	0.03	0.86	FALSE
39	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MED8	0.26	0.18	blup	39	0.24	3.5e-09	5.9	-5.3	9.5e-08	-0.91	0.02	0.97	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	C1orf84	0.03	0.02	blup	46	0.03	7.0e-04	6.1	-5.9	3.4e-09	-0.93	0.03	0.89	FALSE