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chr1:11,032,827-12,600,396

Best TWAS P=9.89e-43 · Best GWAS P=1.64e-39 conditioned to 0.42

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CLCN6	0.14	0.05	enet	36	0.08	1.9e-09	3.64	-5.6	2.7e-08	0.20	0.48	0.08	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MTHFR	0.08	0.08	lasso	3	0.07	9.6e-09	-6.83	-6.8	1.0e-11	0.35	1.00	0.00	FALSE
3	GTEx	Artery Tibial	CLCN6	0.14	0.04	lasso	6	0.04	5.0e-04	-10.12	-8.7	5.0e-18	0.66	0.12	0.86	FALSE
4	GTEx	Brain Cerebellum	MTHFR	0.25	0.09	lasso	4	0.03	3.5e-02	-6.83	-7.1	1.0e-12	0.34	0.15	0.10	FALSE
5	GTEx	Breast Mammary Tissue (Male)	FBXO6	0.39	0.01	lasso	6	0.07	1.1e-02	3.57	6.6	5.2e-11	-0.42	0.04	0.39	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	MTHFR	0.33	0.12	lasso	6	0.09	7.9e-04	-9.58	-9.6	9.6e-22	0.80	0.32	0.30	FALSE
7	GTEx	Cells Transformed fibroblasts	CLCN6	0.08	0.02	enet	17	0.05	1.6e-04	-13.15	-10.1	7.3e-24	0.75	0.01	0.99	FALSE
8	GTEx	Cells Transformed fibroblasts	MTHFR	0.13	0.03	enet	30	0.05	6.8e-05	-9.02	-10.4	2.2e-25	0.57	0.05	0.92	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	CLCN6	0.12	0.03	lasso	3	0.04	3.3e-03	-4.88	-9.7	2.8e-22	0.83	0.02	0.92	FALSE
10	GTEx	Skin Sun Exposed Lower leg	CLCN6	0.08	0.00	lasso	3	0.01	7.9e-02	-7.49	-9.1	6.1e-20	0.67	0.03	0.72	FALSE
11	GTEx	Spleen	CLCN6	0.21	0.10	lasso	3	0.06	1.3e-02	-9.66	-11.1	2.0e-28	0.86	0.04	0.68	FALSE
12	GTEx	Whole Blood	CLCN6	0.10	0.02	lasso	3	0.04	2.1e-04	-10.12	-6.4	1.8e-10	0.47	0.34	0.13	FALSE
13	METSIM	Adipose	CLCN6	0.09	0.04	blup	480	0.06	1.6e-09	-7.93	-9.3	1.2e-20	0.65	0.06	0.94	FALSE
14	NTR	Blood	AGTRAP	0.02	0.00	bslmm	484	0.00	5.2e-02	0.38	5.8	6.2e-09	-0.38	0.05	0.06	FALSE
15	NTR	Blood	CLCN6	0.01	0.01	lasso	2	0.01	3.0e-04	-10.12	-8.1	3.8e-16	0.78	0.40	0.50	FALSE
16	NTR	Blood	MTHFR	0.09	0.07	enet	17	0.10	4.4e-31	-6.83	-10.9	7.6e-28	0.66	1.00	0.00	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	C1orf167	0.07	0.01	blup	475	0.03	1.4e-04	-8.08	-6.6	4.5e-11	0.43	0.36	0.05	FALSE
18	YFS	Blood	MTHFR	0.50	0.49	enet	40	0.62	5.5e-264	-6.83	-9.5	2.7e-21	0.52	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	CLCN6	0.06	0.06	blup	104	0.06	5.0e-12	-10.46	-13.3	1.2e-40	0.75	0.22	0.78	FALSE
20	The Cancer Genome Atlas	Colon Adenocarcinoma	CLCN6	0.14	0.05	blup	104	0.09	1.2e-05	-12.64	-8.8	1.9e-18	0.81	0.01	0.98	TRUE
21	The Cancer Genome Atlas	Colon Adenocarcinoma	MTHFR	0.07	0.01	blup	92	0.04	2.9e-03	-0.90	-9.8	1.2e-22	0.76	0.04	0.46	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CLCN6	0.04	0.06	lasso	2	0.05	1.1e-06	-10.46	-11.6	2.8e-31	0.69	0.10	0.89	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CLCN6	0.05	0.05	lasso	6	0.05	9.2e-07	-7.49	-10.3	1.0e-24	0.51	0.47	0.50	FALSE
24	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CLCN6	0.07	0.00	blup	104	0.03	7.9e-03	2.08	-8.9	4.9e-19	0.60	0.06	0.28	FALSE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	CLCN6	0.06	0.04	blup	104	0.04	5.2e-06	-13.15	-13.7	9.9e-43	0.91	0.01	0.99	TRUE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	MTHFR	0.05	0.02	blup	92	0.02	2.5e-03	-6.83	-7.3	3.5e-13	0.44	0.16	0.06	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	CLCN6	0.10	0.07	blup	104	0.07	3.9e-08	-7.43	-11.3	7.5e-30	0.59	0.21	0.78	FALSE
28	The Cancer Genome Atlas	Stomach Adenocarcinoma	CLCN6	0.07	0.04	blup	104	0.05	2.4e-04	-12.64	-13.2	5.6e-40	0.94	0.01	0.98	FALSE
29	The Cancer Genome Atlas	Stomach Adenocarcinoma	NPPA	0.06	0.03	enet	4	0.04	7.6e-04	-7.43	5.5	5.1e-08	-0.45	0.11	0.14	TRUE
30	The Cancer Genome Atlas	Thyroid Carcinoma	CLCN6	0.08	0.02	blup	104	0.05	2.5e-05	-8.08	-9.0	2.4e-19	0.64	0.16	0.83	FALSE