[Hub]/) : Traits : Systolic blood pressure, automated reading :

chr11:56,774,260-58,178,587

Best TWAS P=6.53e-11 · Best GWAS P=4.55e-08 conditioned to 0.063

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous MED19 0.23 0.06 enet 29 0.18 2.0e-14 4.5 6.0 1.7e-09 -0.68 0.08 0.92 FALSE
2 GTEx Artery Tibial MED19 0.22 0.12 enet 37 0.16 6.6e-13 4.5 5.5 3.4e-08 -0.33 0.33 0.65 FALSE
3 GTEx Breast Mammary Tissue MED19 0.11 0.04 enet 26 0.10 7.5e-06 -5.0 5.2 2.3e-07 -0.64 0.02 0.91 FALSE
4 GTEx Colon Transverse MED19 0.10 0.00 enet 28 0.08 1.4e-04 4.5 5.1 2.8e-07 -0.56 0.06 0.81 FALSE
5 GTEx Lung MED19 0.12 0.00 enet 12 0.06 2.9e-05 4.5 6.5 6.5e-11 -0.61 0.11 0.82 TRUE
6 GTEx Muscle Skeletal MED19 0.06 0.06 lasso 7 0.06 1.9e-06 4.5 5.1 2.8e-07 -0.47 0.32 0.64 FALSE
7 GTEx Nerve Tibial MED19 0.12 0.00 enet 25 0.02 2.1e-02 4.4 5.5 3.2e-08 -0.58 0.23 0.66 FALSE
8 GTEx Pancreas MED19 0.10 0.08 lasso 3 0.02 5.0e-02 -5.1 5.1 3.1e-07 -0.82 0.02 0.84 FALSE
9 GTEx Skin Not Sun Exposed Suprapubic MED19 0.12 0.05 enet 31 0.05 7.5e-04 -5.2 5.6 2.4e-08 -0.76 0.02 0.97 FALSE
10 GTEx Skin Sun Exposed Lower leg MED19 0.15 0.11 lasso 7 0.09 1.3e-07 -5.2 5.5 4.2e-08 -0.84 0.02 0.98 FALSE
11 GTEx Stomach MED19 0.10 0.04 lasso 7 0.09 6.8e-05 -5.1 5.8 8.4e-09 -0.77 0.03 0.88 FALSE
12 GTEx Thyroid MED19 0.11 0.02 lasso 12 0.07 3.2e-06 -3.4 5.8 6.1e-09 -0.53 0.22 0.74 FALSE
13 METSIM Adipose MED19 0.11 0.08 lasso 5 0.07 4.5e-11 4.4 5.2 1.7e-07 -0.57 0.35 0.63 FALSE
14 YFS Blood MED19 0.47 0.18 enet 73 0.28 7.1e-93 4.5 5.6 2.3e-08 -0.54 0.34 0.64 FALSE
15 The Cancer Genome Atlas Bladder Urothelial Carcinoma MED19 0.07 0.01 blup 26 0.05 7.4e-05 4.4 5.3 1.2e-07 -0.66 0.03 0.86 FALSE
16 The Cancer Genome Atlas Breast Invasive Carcinoma MED19 0.05 0.03 enet 7 0.05 1.3e-10 -5.1 5.8 8.0e-09 -0.73 0.01 0.99 FALSE
17 The Cancer Genome Atlas Colon Adenocarcinoma TMX2 0.07 0.06 lasso 1 0.05 5.0e-04 -5.2 -5.2 1.9e-07 0.83 0.00 0.90 FALSE
18 The Cancer Genome Atlas Esophageal Carcinoma MED19 0.10 0.06 lasso 4 0.02 5.4e-02 -5.2 5.2 1.6e-07 -0.82 0.00 0.82 FALSE
19 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MED19 0.03 0.01 lasso 2 0.02 1.9e-03 -5.1 5.3 8.8e-08 -0.61 0.00 0.62 FALSE
20 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma MED19 0.09 0.05 lasso 2 0.07 9.2e-05 4.4 5.5 3.6e-08 -0.64 0.02 0.80 FALSE
21 The Cancer Genome Atlas Lung Adenocarcinoma MED19 0.05 0.02 blup 26 0.03 6.0e-05 -5.2 5.7 1.6e-08 -0.76 0.01 0.99 FALSE
22 The Cancer Genome Atlas Pancreatic Adenocarcinoma MED19 0.13 0.06 blup 26 0.13 4.7e-06 4.4 5.6 2.3e-08 -0.63 0.04 0.83 FALSE
23 The Cancer Genome Atlas Prostate Adenocarcinoma MED19 0.07 0.05 blup 26 0.05 4.4e-06 4.4 5.5 3.4e-08 -0.61 0.14 0.81 FALSE
24 The Cancer Genome Atlas Testicular Germ Cell Tumors MED19 0.10 0.04 blup 26 0.03 3.6e-02 4.4 5.5 3.5e-08 -0.56 0.02 0.38 FALSE
25 The Cancer Genome Atlas Thyroid Carcinoma MED19 0.10 0.05 blup 26 0.09 3.8e-09 4.4 5.5 2.8e-08 -0.72 0.05 0.93 FALSE