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chr11:56,774,260-58,178,587

Best TWAS P=6.53e-11 · Best GWAS P=4.55e-08 conditioned to 0.063

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	MED19	0.23	0.06	enet	29	0.18	2.0e-14	4.5	6.0	1.7e-09	-0.68	0.08	0.92	FALSE
2	GTEx	Artery Tibial	MED19	0.22	0.12	enet	37	0.16	6.6e-13	4.5	5.5	3.4e-08	-0.33	0.33	0.65	FALSE
3	GTEx	Breast Mammary Tissue	MED19	0.11	0.04	enet	26	0.10	7.5e-06	-5.0	5.2	2.3e-07	-0.64	0.02	0.91	FALSE
4	GTEx	Colon Transverse	MED19	0.10	0.00	enet	28	0.08	1.4e-04	4.5	5.1	2.8e-07	-0.56	0.06	0.81	FALSE
5	GTEx	Lung	MED19	0.12	0.00	enet	12	0.06	2.9e-05	4.5	6.5	6.5e-11	-0.61	0.11	0.82	TRUE
6	GTEx	Muscle Skeletal	MED19	0.06	0.06	lasso	7	0.06	1.9e-06	4.5	5.1	2.8e-07	-0.47	0.32	0.64	FALSE
7	GTEx	Nerve Tibial	MED19	0.12	0.00	enet	25	0.02	2.1e-02	4.4	5.5	3.2e-08	-0.58	0.23	0.66	FALSE
8	GTEx	Pancreas	MED19	0.10	0.08	lasso	3	0.02	5.0e-02	-5.1	5.1	3.1e-07	-0.82	0.02	0.84	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	MED19	0.12	0.05	enet	31	0.05	7.5e-04	-5.2	5.6	2.4e-08	-0.76	0.02	0.97	FALSE
10	GTEx	Skin Sun Exposed Lower leg	MED19	0.15	0.11	lasso	7	0.09	1.3e-07	-5.2	5.5	4.2e-08	-0.84	0.02	0.98	FALSE
11	GTEx	Stomach	MED19	0.10	0.04	lasso	7	0.09	6.8e-05	-5.1	5.8	8.4e-09	-0.77	0.03	0.88	FALSE
12	GTEx	Thyroid	MED19	0.11	0.02	lasso	12	0.07	3.2e-06	-3.4	5.8	6.1e-09	-0.53	0.22	0.74	FALSE
13	METSIM	Adipose	MED19	0.11	0.08	lasso	5	0.07	4.5e-11	4.4	5.2	1.7e-07	-0.57	0.35	0.63	FALSE
14	YFS	Blood	MED19	0.47	0.18	enet	73	0.28	7.1e-93	4.5	5.6	2.3e-08	-0.54	0.34	0.64	FALSE
15	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MED19	0.07	0.01	blup	26	0.05	7.4e-05	4.4	5.3	1.2e-07	-0.66	0.03	0.86	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	MED19	0.05	0.03	enet	7	0.05	1.3e-10	-5.1	5.8	8.0e-09	-0.73	0.01	0.99	FALSE
17	The Cancer Genome Atlas	Colon Adenocarcinoma	TMX2	0.07	0.06	lasso	1	0.05	5.0e-04	-5.2	-5.2	1.9e-07	0.83	0.00	0.90	FALSE
18	The Cancer Genome Atlas	Esophageal Carcinoma	MED19	0.10	0.06	lasso	4	0.02	5.4e-02	-5.2	5.2	1.6e-07	-0.82	0.00	0.82	FALSE
19	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MED19	0.03	0.01	lasso	2	0.02	1.9e-03	-5.1	5.3	8.8e-08	-0.61	0.00	0.62	FALSE
20	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MED19	0.09	0.05	lasso	2	0.07	9.2e-05	4.4	5.5	3.6e-08	-0.64	0.02	0.80	FALSE
21	The Cancer Genome Atlas	Lung Adenocarcinoma	MED19	0.05	0.02	blup	26	0.03	6.0e-05	-5.2	5.7	1.6e-08	-0.76	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MED19	0.13	0.06	blup	26	0.13	4.7e-06	4.4	5.6	2.3e-08	-0.63	0.04	0.83	FALSE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	MED19	0.07	0.05	blup	26	0.05	4.4e-06	4.4	5.5	3.4e-08	-0.61	0.14	0.81	FALSE
24	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MED19	0.10	0.04	blup	26	0.03	3.6e-02	4.4	5.5	3.5e-08	-0.56	0.02	0.38	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	MED19	0.10	0.05	blup	26	0.09	3.8e-09	4.4	5.5	2.8e-08	-0.72	0.05	0.93	FALSE