[Hub]/) : Traits : Systolic blood pressure, automated reading :

chr11:46,033,104-48,783,497

Best TWAS P=2.95e-13 · Best GWAS P=1.27e-13 conditioned to 0.000663

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex AGBL2 0.03 0.02 enet 7 0.03 7.9e-05 -6.1 -6.4 1.6e-10 0.71 0.22 0.76 FALSE
2 CommonMind Brain Pre-frontal Cortex LRP4 0.04 0.05 lasso 4 0.04 6.6e-06 -5.3 -5.3 1.2e-07 0.55 0.96 0.02 FALSE
3 CommonMind Brain Pre-frontal Cortex PTPRJ 0.06 0.04 lasso 4 0.05 7.6e-07 -6.5 -7.1 1.6e-12 0.65 0.03 0.97 FALSE
4 GTEx Adipose Visceral Omentum ACP2 0.08 0.05 lasso 5 0.05 1.4e-03 -6.0 5.7 1.1e-08 -0.83 0.13 0.69 FALSE
5 GTEx Breast Mammary Tissue CKAP5 0.09 0.05 enet 16 0.03 1.3e-02 -4.3 -5.1 3.0e-07 0.57 0.47 0.28 FALSE
6 GTEx Breast Mammary Tissue (Female) ACP2 0.03 0.00 lasso 1 0.02 1.0e-01 -6.9 6.9 5.8e-12 -0.78 0.03 0.11 FALSE
7 GTEx Cells EBV-transformed lymphocytes ACP2 0.17 0.03 lasso 6 0.03 4.2e-02 -2.7 6.6 5.2e-11 -0.83 0.05 0.86 FALSE
8 GTEx Cells Transformed fibroblasts PACSIN3 0.07 0.00 enet 7 0.01 1.2e-01 -5.1 5.5 4.6e-08 -0.33 0.12 0.09 FALSE
9 GTEx Esophagus Gastroesophageal Junction NUP160 0.18 0.02 enet 18 0.11 7.1e-05 3.0 -6.0 1.5e-09 0.25 0.27 0.05 FALSE
10 GTEx Esophagus Mucosa ACP2 0.07 0.04 enet 11 0.04 6.2e-04 -6.4 6.4 1.6e-10 -0.93 0.02 0.97 FALSE
11 GTEx Heart Left Ventricle ACP2 0.11 0.06 enet 18 0.10 9.2e-06 -7.2 5.4 6.2e-08 -0.84 0.04 0.95 FALSE
12 GTEx Muscle Skeletal FNBP4 0.05 0.03 lasso 5 0.04 5.0e-05 -6.3 -7.3 3.0e-13 0.67 0.21 0.69 TRUE
13 GTEx Prostate CELF1 0.17 0.16 lasso 2 0.12 6.2e-04 -5.1 -5.1 2.9e-07 0.57 0.18 0.09 FALSE
14 GTEx Skin Not Sun Exposed Suprapubic SLC39A13 0.07 0.11 lasso 2 0.10 5.2e-06 -6.3 -6.3 2.8e-10 0.80 0.20 0.48 FALSE
15 GTEx Testis C1QTNF4 0.14 0.12 lasso 4 0.11 1.6e-05 5.7 5.8 8.8e-09 -0.27 0.83 0.01 FALSE
16 GTEx Thyroid ACP2 0.19 0.14 lasso 4 0.12 3.0e-09 -6.0 5.5 3.6e-08 -0.82 0.73 0.27 FALSE
17 METSIM Adipose NR1H3 0.03 0.03 lasso 6 0.04 4.7e-06 4.2 -5.9 2.8e-09 0.58 0.11 0.85 FALSE
18 NTR Blood ACP2 0.01 0.00 enet 7 0.01 2.5e-03 -6.4 5.5 4.3e-08 -0.90 0.02 0.96 FALSE
19 NTR Blood DDB2 0.01 0.00 lasso 7 0.01 2.2e-03 -5.3 6.4 1.4e-10 -0.86 0.05 0.84 FALSE
20 ROSMAP Brain Pre-frontal Cortex FNBP4 0.04 0.04 lasso 3 0.04 8.2e-06 5.7 -5.5 4.9e-08 0.27 0.99 0.00 FALSE
21 ROSMAP Brain Pre-frontal Cortex PTPMT1 0.03 0.02 blup 270 0.02 3.8e-04 -6.3 -5.5 2.9e-08 0.78 0.09 0.85 FALSE
22 ROSMAP Brain Pre-frontal Cortex LRP4 0.04 0.06 blup 286 0.05 3.5e-07 -5.2 -6.2 4.1e-10 0.79 0.31 0.68 FALSE
23 ROSMAP Brain Pre-frontal Cortex DDB2 0.04 0.03 enet 15 0.03 7.1e-05 -5.2 6.0 1.6e-09 -0.56 0.70 0.25 FALSE
24 ROSMAP Brain Pre-frontal Cortex ZNF408 0.04 0.02 blup 243 0.03 5.0e-05 -4.3 5.7 1.6e-08 -0.61 0.09 0.90 FALSE
25 YFS Blood DDB2 0.02 0.00 bslmm 306 0.01 1.9e-04 -7.3 5.7 1.1e-08 -0.66 0.02 0.91 FALSE
26 The Cancer Genome Atlas Colon Adenocarcinoma PSMC3 0.09 0.05 blup 39 0.05 1.0e-03 4.6 -6.2 4.1e-10 0.35 0.09 0.08 FALSE
27 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ACP2 0.02 0.03 lasso 1 0.02 1.5e-03 -6.0 6.0 1.6e-09 -0.83 0.03 0.68 FALSE
28 The Cancer Genome Atlas Prostate Adenocarcinoma AGBL2 0.04 0.03 blup 49 0.03 7.8e-04 5.1 -6.5 1.1e-10 0.50 0.10 0.48 FALSE
29 The Cancer Genome Atlas Testicular Germ Cell Tumors MADD 0.21 0.04 blup 64 0.07 1.3e-03 -7.2 6.4 1.6e-10 -0.84 0.01 0.82 FALSE
30 The Cancer Genome Atlas Thyroid Carcinoma DDB2 0.06 0.04 enet 17 0.03 1.3e-03 -7.3 -5.4 7.8e-08 0.85 0.00 0.99 FALSE
31 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma ZNF408 0.27 0.01 blup 27 0.09 1.5e-03 -4.5 5.4 6.1e-08 -0.57 0.00 0.35 FALSE