Best TWAS P=2.25e-09 · Best GWAS P=2.64e-08 conditioned to 0.247
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | LACTB | 0.12 | 0.14 | lasso | 2 | 0.14 | 1.2e-16 | -5.4 | -5.2 | 2.7e-07 | -0.80 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Subcutaneous | LACTB | 0.11 | 0.10 | enet | 11 | 0.07 | 2.3e-06 | -5.4 | -5.6 | 2.4e-08 | -0.86 | 0.01 | 0.99 | FALSE |
3 | GTEx | Adipose Visceral Omentum | LACTB | 0.16 | 0.11 | lasso | 3 | 0.09 | 2.7e-05 | -5.4 | -5.2 | 2.0e-07 | -0.87 | 0.01 | 0.99 | FALSE |
4 | GTEx | Esophagus Muscularis | LACTB | 0.12 | 0.05 | lasso | 9 | 0.06 | 1.3e-04 | -5.4 | -5.8 | 8.3e-09 | -0.89 | 0.02 | 0.98 | FALSE |
5 | GTEx | Heart Atrial Appendage | LACTB | 0.17 | 0.05 | lasso | 5 | 0.08 | 2.2e-04 | -5.4 | -5.3 | 1.3e-07 | -0.91 | 0.01 | 0.99 | FALSE |
6 | GTEx | Lung | LACTB | 0.10 | 0.09 | lasso | 4 | 0.08 | 9.2e-07 | -5.4 | -5.6 | 2.6e-08 | -0.88 | 0.01 | 0.99 | FALSE |
7 | GTEx | Thyroid | LACTB | 0.10 | 0.03 | lasso | 4 | 0.02 | 1.0e-02 | -5.4 | -5.5 | 4.5e-08 | -0.89 | 0.01 | 0.98 | FALSE |
8 | METSIM | Adipose | LACTB | 0.17 | 0.20 | lasso | 4 | 0.20 | 1.3e-28 | -5.4 | -5.3 | 1.2e-07 | -0.85 | 0.01 | 0.99 | FALSE |
9 | YFS | Blood | LACTB | 0.07 | 0.06 | lasso | 6 | 0.09 | 1.0e-26 | -5.4 | -5.8 | 6.6e-09 | -0.89 | 0.01 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Glioblastoma Multiforme | LACTB | 0.25 | 0.04 | enet | 12 | 0.19 | 1.9e-06 | 4.9 | -6.0 | 2.2e-09 | -0.82 | 0.02 | 0.95 | TRUE |
11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LACTB | 0.04 | 0.01 | blup | 52 | 0.02 | 2.5e-03 | 4.7 | -5.4 | 7.5e-08 | -0.85 | 0.02 | 0.94 | FALSE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LACTB | 0.16 | 0.20 | enet | 8 | 0.21 | 2.5e-23 | -5.4 | -5.6 | 2.8e-08 | -0.89 | 0.01 | 0.99 | FALSE |
13 | The Cancer Genome Atlas | Lung Adenocarcinoma | LACTB | 0.04 | 0.07 | lasso | 5 | 0.06 | 8.2e-08 | -5.4 | -5.6 | 2.0e-08 | -0.89 | 0.01 | 0.99 | FALSE |
14 | The Cancer Genome Atlas | Lung Adenocarcinoma | TPM1 | 0.05 | 0.04 | blup | 80 | 0.05 | 1.3e-06 | 3.2 | -5.4 | 8.2e-08 | -0.55 | 0.58 | 0.32 | FALSE |