[Hub]/) : Traits : Systolic blood pressure, automated reading :

chr15:39,530,508-42,749,023

Best TWAS P=8.26e-13 · Best GWAS P=9.49e-12 conditioned to 0.0135

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex EXD1 0.04 0.04 lasso 3 0.04 8.1e-06 6.1 -5.8 6.4e-09 -0.87 0.03 0.97 FALSE
2 CommonMind Brain Pre-frontal Cortex SRP14 0.18 0.04 lasso 7 0.07 5.0e-09 2.6 -5.2 2.6e-07 -0.03 0.10 0.90 FALSE
3 GTEx Adipose Visceral Omentum EIF2AK4 0.23 0.08 lasso 7 0.15 2.7e-08 -6.7 -6.3 2.8e-10 -0.02 0.00 0.99 FALSE
4 GTEx Artery Aorta OIP5-AS1 0.16 0.21 enet 26 0.23 5.2e-13 5.2 5.3 1.3e-07 0.65 0.89 0.11 FALSE
5 GTEx Brain Cerebellum SRP14 0.26 0.00 enet 8 0.04 2.3e-02 -6.7 -5.2 2.0e-07 0.03 0.01 0.80 FALSE
6 GTEx Brain Cortex GCHFR 0.25 0.04 enet 15 0.05 1.4e-02 6.1 -6.3 2.9e-10 -0.87 0.03 0.74 FALSE
7 GTEx Breast Mammary Tissue EIF2AK4 0.24 0.10 lasso 8 0.06 3.2e-04 -6.7 -6.5 7.3e-11 0.00 0.00 1.00 FALSE
8 GTEx Breast Mammary Tissue OIP5-AS1 0.20 0.24 lasso 7 0.22 1.8e-11 5.7 5.4 7.4e-08 0.60 0.89 0.11 FALSE
9 GTEx Breast Mammary Tissue (Female) OIP5-AS1 0.28 0.31 lasso 3 0.29 3.0e-09 5.7 5.7 1.0e-08 0.62 0.71 0.28 FALSE
10 GTEx Cells EBV-transformed lymphocytes EIF2AK4 0.31 -0.01 enet 11 0.06 6.4e-03 -6.0 -5.5 4.2e-08 0.01 0.06 0.17 FALSE
11 GTEx Colon Sigmoid NDUFAF1 0.15 0.06 lasso 4 0.06 5.2e-03 4.5 -5.2 2.1e-07 -0.61 0.21 0.48 FALSE
12 GTEx Colon Transverse EIF2AK4 0.40 0.16 lasso 4 0.15 9.2e-08 -5.9 -6.2 6.4e-10 0.02 0.00 0.99 FALSE
13 GTEx Esophagus Mucosa EIF2AK4 0.30 0.11 lasso 6 0.14 9.4e-10 -5.9 -6.6 4.5e-11 0.01 0.00 1.00 FALSE
14 GTEx Esophagus Mucosa CHP1 0.19 0.10 lasso 7 0.09 1.4e-06 5.7 -5.7 9.6e-09 -0.82 0.04 0.96 FALSE
15 GTEx Lung EIF2AK4 0.14 0.12 enet 10 0.12 2.0e-09 -5.9 -5.6 2.2e-08 0.00 0.09 0.91 FALSE
16 GTEx Lung OIP5-AS1 0.09 0.08 enet 14 0.12 2.8e-09 6.4 5.9 3.9e-09 0.83 0.04 0.96 FALSE
17 GTEx Nerve Tibial NUSAP1 0.15 0.09 enet 10 0.15 9.8e-11 3.0 5.3 1.4e-07 0.71 0.60 0.40 FALSE
18 GTEx Pancreas EIF2AK4 0.40 0.29 lasso 5 0.29 7.6e-13 -6.7 -7.2 8.3e-13 0.03 0.00 1.00 TRUE
19 GTEx Pancreas OIP5-AS1 0.07 0.13 lasso 2 0.10 7.5e-05 5.7 5.3 8.9e-08 0.56 0.53 0.17 FALSE
20 GTEx Skin Sun Exposed Lower leg DNAJC17 0.08 0.04 enet 9 0.02 5.6e-03 4.6 5.3 1.3e-07 0.66 0.13 0.33 FALSE
21 GTEx Skin Sun Exposed Lower leg EIF2AK4 0.34 0.15 enet 16 0.15 9.4e-13 -6.7 -6.2 4.8e-10 0.02 0.00 1.00 FALSE
22 GTEx Skin Sun Exposed Lower leg CHP1 0.06 0.04 enet 9 0.04 3.1e-04 6.4 -5.9 3.9e-09 -0.82 0.03 0.94 FALSE
23 GTEx Testis OIP5-AS1 0.14 0.16 lasso 1 0.14 8.6e-07 5.7 5.7 1.4e-08 0.56 0.69 0.16 FALSE
24 GTEx Thyroid EIF2AK4 0.31 0.18 enet 15 0.23 3.0e-17 -5.9 -6.3 3.9e-10 0.00 0.00 1.00 FALSE
25 GTEx Thyroid OIP5-AS1 0.20 0.19 lasso 8 0.20 4.1e-15 5.7 5.7 9.5e-09 0.66 0.87 0.13 FALSE
26 NTR Blood INO80 0.02 0.02 enet 8 0.03 2.8e-09 6.0 -6.1 1.0e-09 -0.94 0.09 0.91 FALSE
27 YFS Blood MGA 0.01 0.00 blup 454 0.00 7.1e-02 5.4 5.7 1.1e-08 0.57 0.02 0.82 FALSE
28 YFS Blood SRP14 0.56 0.35 enet 68 0.54 4.4e-213 -6.0 -6.1 1.0e-09 -0.01 0.12 0.88 FALSE
29 The Cancer Genome Atlas Breast Invasive Carcinoma CHP 0.01 0.01 blup 54 0.01 1.4e-02 6.6 -6.9 5.9e-12 -0.81 0.01 0.90 TRUE
30 The Cancer Genome Atlas Breast Invasive Carcinoma EIF2AK4 0.05 0.03 lasso 7 0.03 9.5e-07 -6.7 -6.3 2.4e-10 0.00 0.00 1.00 FALSE
31 The Cancer Genome Atlas Esophageal Carcinoma EIF2AK4 0.16 0.07 lasso 6 0.13 7.2e-05 -6.7 -5.2 2.6e-07 0.01 0.01 0.92 FALSE
32 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma EIF2AK4 0.11 0.04 lasso 4 0.06 2.1e-07 -6.7 -5.7 1.1e-08 0.00 0.00 1.00 FALSE
33 The Cancer Genome Atlas Pancreatic Adenocarcinoma INO80 0.07 0.04 blup 40 0.06 1.2e-03 4.4 5.9 3.0e-09 0.94 0.02 0.82 FALSE
34 The Cancer Genome Atlas Pancreatic Adenocarcinoma LOC729082 0.31 0.00 blup 43 0.00 5.5e-01 4.4 5.2 2.0e-07 0.51 0.01 0.38 FALSE
35 The Cancer Genome Atlas Thyroid Carcinoma EIF2AK4 0.15 0.07 lasso 5 0.09 4.9e-09 -6.7 -6.6 3.6e-11 0.00 0.00 1.00 FALSE
36 The Cancer Genome Atlas Thyroid Carcinoma INO80 0.03 0.02 blup 39 0.03 1.0e-03 2.4 5.5 3.0e-08 0.93 0.02 0.95 FALSE