Best TWAS P=8.26e-13 · Best GWAS P=9.49e-12 conditioned to 0.0135
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EXD1 | 0.04 | 0.04 | lasso | 3 | 0.04 | 8.1e-06 | 6.1 | -5.8 | 6.4e-09 | -0.87 | 0.03 | 0.97 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SRP14 | 0.18 | 0.04 | lasso | 7 | 0.07 | 5.0e-09 | 2.6 | -5.2 | 2.6e-07 | -0.03 | 0.10 | 0.90 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | EIF2AK4 | 0.23 | 0.08 | lasso | 7 | 0.15 | 2.7e-08 | -6.7 | -6.3 | 2.8e-10 | -0.02 | 0.00 | 0.99 | FALSE |
| 4 | GTEx | Artery Aorta | OIP5-AS1 | 0.16 | 0.21 | enet | 26 | 0.23 | 5.2e-13 | 5.2 | 5.3 | 1.3e-07 | 0.65 | 0.89 | 0.11 | FALSE |
| 5 | GTEx | Brain Cerebellum | SRP14 | 0.26 | 0.00 | enet | 8 | 0.04 | 2.3e-02 | -6.7 | -5.2 | 2.0e-07 | 0.03 | 0.01 | 0.80 | FALSE |
| 6 | GTEx | Brain Cortex | GCHFR | 0.25 | 0.04 | enet | 15 | 0.05 | 1.4e-02 | 6.1 | -6.3 | 2.9e-10 | -0.87 | 0.03 | 0.74 | FALSE |
| 7 | GTEx | Breast Mammary Tissue | EIF2AK4 | 0.24 | 0.10 | lasso | 8 | 0.06 | 3.2e-04 | -6.7 | -6.5 | 7.3e-11 | 0.00 | 0.00 | 1.00 | FALSE |
| 8 | GTEx | Breast Mammary Tissue | OIP5-AS1 | 0.20 | 0.24 | lasso | 7 | 0.22 | 1.8e-11 | 5.7 | 5.4 | 7.4e-08 | 0.60 | 0.89 | 0.11 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Female) | OIP5-AS1 | 0.28 | 0.31 | lasso | 3 | 0.29 | 3.0e-09 | 5.7 | 5.7 | 1.0e-08 | 0.62 | 0.71 | 0.28 | FALSE |
| 10 | GTEx | Cells EBV-transformed lymphocytes | EIF2AK4 | 0.31 | -0.01 | enet | 11 | 0.06 | 6.4e-03 | -6.0 | -5.5 | 4.2e-08 | 0.01 | 0.06 | 0.17 | FALSE |
| 11 | GTEx | Colon Sigmoid | NDUFAF1 | 0.15 | 0.06 | lasso | 4 | 0.06 | 5.2e-03 | 4.5 | -5.2 | 2.1e-07 | -0.61 | 0.21 | 0.48 | FALSE |
| 12 | GTEx | Colon Transverse | EIF2AK4 | 0.40 | 0.16 | lasso | 4 | 0.15 | 9.2e-08 | -5.9 | -6.2 | 6.4e-10 | 0.02 | 0.00 | 0.99 | FALSE |
| 13 | GTEx | Esophagus Mucosa | EIF2AK4 | 0.30 | 0.11 | lasso | 6 | 0.14 | 9.4e-10 | -5.9 | -6.6 | 4.5e-11 | 0.01 | 0.00 | 1.00 | FALSE |
| 14 | GTEx | Esophagus Mucosa | CHP1 | 0.19 | 0.10 | lasso | 7 | 0.09 | 1.4e-06 | 5.7 | -5.7 | 9.6e-09 | -0.82 | 0.04 | 0.96 | FALSE |
| 15 | GTEx | Lung | EIF2AK4 | 0.14 | 0.12 | enet | 10 | 0.12 | 2.0e-09 | -5.9 | -5.6 | 2.2e-08 | 0.00 | 0.09 | 0.91 | FALSE |
| 16 | GTEx | Lung | OIP5-AS1 | 0.09 | 0.08 | enet | 14 | 0.12 | 2.8e-09 | 6.4 | 5.9 | 3.9e-09 | 0.83 | 0.04 | 0.96 | FALSE |
| 17 | GTEx | Nerve Tibial | NUSAP1 | 0.15 | 0.09 | enet | 10 | 0.15 | 9.8e-11 | 3.0 | 5.3 | 1.4e-07 | 0.71 | 0.60 | 0.40 | FALSE |
| 18 | GTEx | Pancreas | EIF2AK4 | 0.40 | 0.29 | lasso | 5 | 0.29 | 7.6e-13 | -6.7 | -7.2 | 8.3e-13 | 0.03 | 0.00 | 1.00 | TRUE |
| 19 | GTEx | Pancreas | OIP5-AS1 | 0.07 | 0.13 | lasso | 2 | 0.10 | 7.5e-05 | 5.7 | 5.3 | 8.9e-08 | 0.56 | 0.53 | 0.17 | FALSE |
| 20 | GTEx | Skin Sun Exposed Lower leg | DNAJC17 | 0.08 | 0.04 | enet | 9 | 0.02 | 5.6e-03 | 4.6 | 5.3 | 1.3e-07 | 0.66 | 0.13 | 0.33 | FALSE |
| 21 | GTEx | Skin Sun Exposed Lower leg | EIF2AK4 | 0.34 | 0.15 | enet | 16 | 0.15 | 9.4e-13 | -6.7 | -6.2 | 4.8e-10 | 0.02 | 0.00 | 1.00 | FALSE |
| 22 | GTEx | Skin Sun Exposed Lower leg | CHP1 | 0.06 | 0.04 | enet | 9 | 0.04 | 3.1e-04 | 6.4 | -5.9 | 3.9e-09 | -0.82 | 0.03 | 0.94 | FALSE |
| 23 | GTEx | Testis | OIP5-AS1 | 0.14 | 0.16 | lasso | 1 | 0.14 | 8.6e-07 | 5.7 | 5.7 | 1.4e-08 | 0.56 | 0.69 | 0.16 | FALSE |
| 24 | GTEx | Thyroid | EIF2AK4 | 0.31 | 0.18 | enet | 15 | 0.23 | 3.0e-17 | -5.9 | -6.3 | 3.9e-10 | 0.00 | 0.00 | 1.00 | FALSE |
| 25 | GTEx | Thyroid | OIP5-AS1 | 0.20 | 0.19 | lasso | 8 | 0.20 | 4.1e-15 | 5.7 | 5.7 | 9.5e-09 | 0.66 | 0.87 | 0.13 | FALSE |
| 26 | NTR | Blood | INO80 | 0.02 | 0.02 | enet | 8 | 0.03 | 2.8e-09 | 6.0 | -6.1 | 1.0e-09 | -0.94 | 0.09 | 0.91 | FALSE |
| 27 | YFS | Blood | MGA | 0.01 | 0.00 | blup | 454 | 0.00 | 7.1e-02 | 5.4 | 5.7 | 1.1e-08 | 0.57 | 0.02 | 0.82 | FALSE |
| 28 | YFS | Blood | SRP14 | 0.56 | 0.35 | enet | 68 | 0.54 | 4.4e-213 | -6.0 | -6.1 | 1.0e-09 | -0.01 | 0.12 | 0.88 | FALSE |
| 29 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CHP | 0.01 | 0.01 | blup | 54 | 0.01 | 1.4e-02 | 6.6 | -6.9 | 5.9e-12 | -0.81 | 0.01 | 0.90 | TRUE |
| 30 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EIF2AK4 | 0.05 | 0.03 | lasso | 7 | 0.03 | 9.5e-07 | -6.7 | -6.3 | 2.4e-10 | 0.00 | 0.00 | 1.00 | FALSE |
| 31 | The Cancer Genome Atlas | Esophageal Carcinoma | EIF2AK4 | 0.16 | 0.07 | lasso | 6 | 0.13 | 7.2e-05 | -6.7 | -5.2 | 2.6e-07 | 0.01 | 0.01 | 0.92 | FALSE |
| 32 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | EIF2AK4 | 0.11 | 0.04 | lasso | 4 | 0.06 | 2.1e-07 | -6.7 | -5.7 | 1.1e-08 | 0.00 | 0.00 | 1.00 | FALSE |
| 33 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | INO80 | 0.07 | 0.04 | blup | 40 | 0.06 | 1.2e-03 | 4.4 | 5.9 | 3.0e-09 | 0.94 | 0.02 | 0.82 | FALSE |
| 34 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LOC729082 | 0.31 | 0.00 | blup | 43 | 0.00 | 5.5e-01 | 4.4 | 5.2 | 2.0e-07 | 0.51 | 0.01 | 0.38 | FALSE |
| 35 | The Cancer Genome Atlas | Thyroid Carcinoma | EIF2AK4 | 0.15 | 0.07 | lasso | 5 | 0.09 | 4.9e-09 | -6.7 | -6.6 | 3.6e-11 | 0.00 | 0.00 | 1.00 | FALSE |
| 36 | The Cancer Genome Atlas | Thyroid Carcinoma | INO80 | 0.03 | 0.02 | blup | 39 | 0.03 | 1.0e-03 | 2.4 | 5.5 | 3.0e-08 | 0.93 | 0.02 | 0.95 | FALSE |