[Hub]/) : Traits : Systolic blood pressure, automated reading :

chr15:74,042,497-75,930,199

Best TWAS P=1.09e-14 · Best GWAS P=4.47e-15 conditioned to 0.065

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex MPI 0.13 0.11 blup 277 0.14 1.6e-16 6.6 -6.0 1.7e-09 -0.56 0.99 0.01 FALSE
2 GTEx Adipose Subcutaneous ULK3 0.22 0.10 enet 19 0.12 2.9e-10 7.5 6.1 9.7e-10 0.73 0.05 0.95 FALSE
3 GTEx Adipose Subcutaneous FAM219B 0.07 0.01 lasso 6 0.02 1.4e-02 5.2 -6.0 2.3e-09 -0.65 0.32 0.25 FALSE
4 GTEx Adipose Subcutaneous CTD-2235H24.2 0.09 0.01 lasso 13 0.01 1.2e-01 7.0 -6.4 1.8e-10 -0.71 0.28 0.25 FALSE
5 GTEx Adipose Visceral Omentum ULK3 0.13 0.12 enet 8 0.11 3.3e-06 7.5 7.4 1.1e-13 0.88 0.04 0.96 FALSE
6 GTEx Artery Tibial ULK3 0.06 0.04 enet 12 0.03 1.7e-03 7.6 6.8 7.8e-12 0.81 0.05 0.82 FALSE
7 GTEx Brain Caudate basal ganglia MPI 0.23 0.25 lasso 4 0.23 3.1e-07 6.7 -6.8 1.4e-11 -0.78 0.13 0.84 FALSE
8 GTEx Brain Cerebellum MPI 0.14 0.09 enet 13 0.09 9.7e-04 -2.6 -5.2 1.8e-07 -0.68 0.12 0.72 FALSE
9 GTEx Brain Frontal Cortex BA9 MPI 0.29 0.12 lasso 10 0.19 9.7e-06 6.4 -7.2 4.5e-13 -0.79 0.11 0.86 FALSE
10 GTEx Brain Hippocampus MPI 0.13 0.07 lasso 3 0.06 1.7e-02 7.3 -6.9 6.7e-12 -0.80 0.05 0.39 FALSE
11 GTEx Brain Nucleus accumbens basal ganglia MPI 0.33 0.12 enet 29 0.34 8.6e-10 6.4 -5.9 4.3e-09 -0.69 0.04 0.95 FALSE
12 GTEx Brain Putamen basal ganglia MPI 0.31 0.18 enet 26 0.23 2.9e-06 6.7 -6.4 1.3e-10 -0.78 0.07 0.91 FALSE
13 GTEx Breast Mammary Tissue ULK3 0.15 0.11 lasso 3 0.09 1.6e-05 6.7 6.8 1.2e-11 0.78 0.14 0.85 FALSE
14 GTEx Breast Mammary Tissue MPI 0.16 0.00 lasso 8 0.01 1.4e-01 4.4 -5.2 1.6e-07 -0.60 0.05 0.36 FALSE
15 GTEx Breast Mammary Tissue (Male) ULK3 0.19 0.19 lasso 2 0.15 2.4e-04 6.3 6.4 1.6e-10 0.67 0.07 0.20 FALSE
16 GTEx Breast Mammary Tissue (Male) MPI 0.06 0.01 enet 4 0.03 5.7e-02 4.4 -6.7 2.4e-11 -0.58 0.02 0.15 FALSE
17 GTEx Breast Mammary Tissue (Female) ULK3 0.08 0.01 lasso 2 0.01 1.8e-01 7.3 7.2 4.0e-13 0.82 0.04 0.28 FALSE
18 GTEx Cells EBV-transformed lymphocytes ULK3 0.19 0.04 lasso 2 0.08 1.2e-03 7.1 7.1 1.6e-12 0.81 0.08 0.76 FALSE
19 GTEx Cells Transformed fibroblasts ULK3 0.12 0.04 lasso 5 0.10 8.4e-08 7.0 6.1 8.9e-10 0.75 0.42 0.58 FALSE
20 GTEx Cells Transformed fibroblasts MPI 0.21 0.16 enet 15 0.22 1.1e-16 6.4 -6.8 7.9e-12 -0.81 0.29 0.71 FALSE
21 GTEx Esophagus Mucosa COX5A 0.11 0.02 enet 23 0.03 6.9e-03 6.3 -5.3 1.4e-07 -0.49 0.08 0.40 FALSE
22 GTEx Esophagus Mucosa MPI 0.11 0.11 lasso 7 0.10 2.3e-07 4.5 -5.3 1.4e-07 -0.64 0.71 0.29 FALSE
23 GTEx Lung CSK 0.09 0.06 lasso 3 0.05 1.4e-04 7.7 7.7 1.1e-14 0.95 0.02 0.98 FALSE
24 GTEx Muscle Skeletal UBL7 0.06 0.02 lasso 6 0.01 3.7e-02 7.4 -7.7 1.1e-14 -0.92 0.02 0.89 TRUE
25 GTEx Nerve Tibial MPI 0.10 0.12 enet 12 0.15 1.5e-10 4.4 -6.0 2.1e-09 -0.77 0.19 0.81 FALSE
26 GTEx Ovary ULK3 0.19 0.23 lasso 1 0.23 3.0e-06 7.3 7.3 4.0e-13 0.82 0.08 0.53 FALSE
27 GTEx Pancreas ULK3 0.12 0.10 lasso 4 0.07 6.9e-04 7.1 7.3 3.6e-13 0.84 0.07 0.90 FALSE
28 GTEx Skin Sun Exposed Lower leg MPI 0.04 0.01 lasso 4 0.02 7.4e-03 4.4 -5.6 1.8e-08 -0.72 0.27 0.56 FALSE
29 GTEx Stomach ULK3 0.16 0.13 lasso 2 0.11 9.7e-06 7.1 7.2 4.1e-13 0.80 0.19 0.79 FALSE
30 GTEx Testis ULK3 0.15 0.03 enet 24 0.06 1.6e-03 7.4 6.3 2.3e-10 0.71 0.08 0.86 FALSE
31 GTEx Testis MPI 0.09 0.08 enet 12 0.04 6.0e-03 4.5 -5.8 5.6e-09 -0.67 0.10 0.66 FALSE
32 GTEx Thyroid ULK3 0.11 0.09 lasso 4 0.13 5.9e-10 7.3 7.3 4.0e-13 0.74 0.16 0.84 FALSE
33 GTEx Thyroid MPI 0.06 0.07 enet 12 0.07 5.1e-06 4.5 -5.4 6.5e-08 -0.66 0.78 0.21 FALSE
34 GTEx Uterus ULK3 0.40 0.16 lasso 16 0.12 2.2e-03 7.0 6.6 4.5e-11 0.73 0.04 0.70 FALSE
35 GTEx Vagina COX5A 0.38 0.02 lasso 7 0.02 9.3e-02 7.4 -7.3 2.6e-13 -0.84 0.04 0.60 FALSE
36 GTEx Whole Blood ULK3 0.14 0.06 lasso 5 0.04 8.3e-05 7.3 6.8 8.1e-12 0.81 0.15 0.82 FALSE
37 GTEx Whole Blood MPI 0.04 0.04 lasso 2 0.01 1.7e-02 6.6 -6.4 1.2e-10 -0.64 0.20 0.20 FALSE
38 METSIM Adipose MPI 0.08 0.06 blup 273 0.07 3.1e-11 6.4 -5.6 1.8e-08 -0.62 0.99 0.01 FALSE
39 METSIM Adipose ULK3 0.14 0.14 lasso 10 0.15 3.2e-22 7.3 7.5 8.4e-14 0.91 0.04 0.96 FALSE
40 YFS Blood CSK 0.13 0.15 lasso 11 0.16 6.7e-51 6.8 7.5 9.2e-14 0.90 0.88 0.12 FALSE
41 YFS Blood MPI 0.02 0.02 lasso 4 0.03 1.2e-09 6.4 -6.4 1.4e-10 -0.73 0.92 0.08 FALSE
42 YFS Blood ULK3 0.09 0.11 lasso 6 0.11 1.1e-33 7.3 7.5 7.7e-14 0.85 0.23 0.77 FALSE
43 The Cancer Genome Atlas Breast Invasive Carcinoma C15orf17 0.02 0.02 lasso 1 0.02 1.9e-05 6.3 -6.3 2.2e-10 -0.72 0.02 0.97 FALSE
44 The Cancer Genome Atlas Breast Invasive Carcinoma MPI 0.04 0.07 enet 13 0.06 5.8e-13 4.5 -5.3 1.2e-07 -0.63 0.87 0.13 FALSE
45 The Cancer Genome Atlas Breast Invasive Carcinoma RPP25 0.02 0.01 blup 23 0.02 6.8e-05 6.6 5.2 1.9e-07 0.58 0.00 0.98 FALSE
46 The Cancer Genome Atlas Breast Invasive Carcinoma ULK3 0.02 0.02 blup 49 0.02 1.1e-05 7.3 7.5 5.7e-14 0.85 0.02 0.98 FALSE
47 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma ULK3 0.21 0.02 enet 8 0.07 1.9e-04 7.4 5.9 3.0e-09 0.70 0.01 0.76 FALSE
48 The Cancer Genome Atlas Colon Adenocarcinoma MPI 0.07 0.03 blup 36 0.04 2.1e-03 6.6 -6.4 1.8e-10 -0.72 0.01 0.94 FALSE
49 The Cancer Genome Atlas Glioblastoma Multiforme MPI 0.11 0.03 blup 36 0.02 8.4e-02 6.6 -6.5 6.0e-11 -0.73 0.01 0.71 FALSE
50 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MPI 0.02 0.01 blup 36 0.01 1.2e-02 6.3 -6.1 1.2e-09 -0.71 0.02 0.66 FALSE
51 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CSK 0.02 0.00 blup 57 0.01 1.8e-02 6.9 5.2 1.7e-07 0.66 0.02 0.59 FALSE
52 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ULK3 0.03 0.03 lasso 3 0.03 5.3e-04 7.0 7.3 2.3e-13 0.85 0.02 0.97 FALSE
53 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma MPI 0.06 0.04 blup 35 0.05 8.5e-04 6.7 -6.6 3.9e-11 -0.75 0.01 0.94 FALSE
54 The Cancer Genome Atlas Brain Lower Grade Glioma MPI 0.07 0.09 lasso 4 0.10 2.4e-11 6.3 -6.1 1.3e-09 -0.72 0.01 0.99 FALSE
55 The Cancer Genome Atlas Brain Lower Grade Glioma SCAMP2 0.18 0.04 enet 5 0.06 6.1e-07 7.3 -5.9 3.0e-09 -0.55 0.03 0.96 FALSE
56 The Cancer Genome Atlas Liver Hepatocellular Carcinoma ULK3 0.10 0.02 blup 49 0.07 2.5e-04 7.5 7.1 1.0e-12 0.85 0.01 0.98 FALSE
57 The Cancer Genome Atlas Lung Adenocarcinoma C15orf17 0.02 0.03 lasso 1 0.02 1.5e-03 6.4 -6.4 1.9e-10 -0.72 0.01 0.80 FALSE
58 The Cancer Genome Atlas Lung Adenocarcinoma ULK3 0.03 0.00 blup 50 0.00 8.1e-02 6.4 6.1 9.7e-10 0.74 0.03 0.40 FALSE
59 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MPI 0.04 0.03 blup 36 0.05 8.8e-07 6.3 -5.8 5.8e-09 -0.68 0.02 0.98 FALSE
60 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ULK3 0.04 0.06 lasso 4 0.04 7.6e-06 7.0 7.2 4.0e-13 0.82 0.02 0.98 FALSE
61 The Cancer Genome Atlas Prostate Adenocarcinoma MPI 0.07 0.07 blup 36 0.10 3.3e-10 4.5 -5.7 9.8e-09 -0.69 0.06 0.94 FALSE
62 The Cancer Genome Atlas Soft Tissue Sarcoma ULK3 0.04 0.03 blup 49 0.02 3.3e-02 6.7 5.6 1.9e-08 0.74 0.01 0.66 FALSE
63 The Cancer Genome Atlas Stomach Adenocarcinoma COX5A 0.03 0.03 blup 32 0.03 2.9e-03 -3.9 -5.3 1.0e-07 -0.65 0.03 0.47 FALSE
64 The Cancer Genome Atlas Stomach Adenocarcinoma MPI 0.04 0.02 blup 36 0.03 1.7e-03 6.4 -6.0 1.6e-09 -0.70 0.03 0.89 FALSE
65 The Cancer Genome Atlas Testicular Germ Cell Tumors MPI 0.12 0.11 lasso 7 0.12 5.3e-05 6.3 -6.2 4.4e-10 -0.72 0.02 0.95 FALSE
66 The Cancer Genome Atlas Thyroid Carcinoma CSK 0.04 0.04 blup 57 0.04 4.6e-05 7.6 6.0 1.7e-09 0.79 0.01 0.97 FALSE
67 The Cancer Genome Atlas Thyroid Carcinoma MPI 0.13 0.18 enet 10 0.16 3.7e-15 4.5 -5.5 4.9e-08 -0.65 0.98 0.02 FALSE
68 The Cancer Genome Atlas Thyroid Carcinoma ULK3 0.08 0.11 lasso 5 0.10 4.6e-10 7.0 7.3 3.1e-13 0.85 0.03 0.97 FALSE