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chr15:74,042,497-75,930,199

Best TWAS P=1.09e-14 · Best GWAS P=4.47e-15 conditioned to 0.065

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MPI	0.13	0.11	blup	277	0.14	1.6e-16	6.6	-6.0	1.7e-09	-0.56	0.99	0.01	FALSE
2	GTEx	Adipose Subcutaneous	ULK3	0.22	0.10	enet	19	0.12	2.9e-10	7.5	6.1	9.7e-10	0.73	0.05	0.95	FALSE
3	GTEx	Adipose Subcutaneous	FAM219B	0.07	0.01	lasso	6	0.02	1.4e-02	5.2	-6.0	2.3e-09	-0.65	0.32	0.25	FALSE
4	GTEx	Adipose Subcutaneous	CTD-2235H24.2	0.09	0.01	lasso	13	0.01	1.2e-01	7.0	-6.4	1.8e-10	-0.71	0.28	0.25	FALSE
5	GTEx	Adipose Visceral Omentum	ULK3	0.13	0.12	enet	8	0.11	3.3e-06	7.5	7.4	1.1e-13	0.88	0.04	0.96	FALSE
6	GTEx	Artery Tibial	ULK3	0.06	0.04	enet	12	0.03	1.7e-03	7.6	6.8	7.8e-12	0.81	0.05	0.82	FALSE
7	GTEx	Brain Caudate basal ganglia	MPI	0.23	0.25	lasso	4	0.23	3.1e-07	6.7	-6.8	1.4e-11	-0.78	0.13	0.84	FALSE
8	GTEx	Brain Cerebellum	MPI	0.14	0.09	enet	13	0.09	9.7e-04	-2.6	-5.2	1.8e-07	-0.68	0.12	0.72	FALSE
9	GTEx	Brain Frontal Cortex BA9	MPI	0.29	0.12	lasso	10	0.19	9.7e-06	6.4	-7.2	4.5e-13	-0.79	0.11	0.86	FALSE
10	GTEx	Brain Hippocampus	MPI	0.13	0.07	lasso	3	0.06	1.7e-02	7.3	-6.9	6.7e-12	-0.80	0.05	0.39	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	MPI	0.33	0.12	enet	29	0.34	8.6e-10	6.4	-5.9	4.3e-09	-0.69	0.04	0.95	FALSE
12	GTEx	Brain Putamen basal ganglia	MPI	0.31	0.18	enet	26	0.23	2.9e-06	6.7	-6.4	1.3e-10	-0.78	0.07	0.91	FALSE
13	GTEx	Breast Mammary Tissue	ULK3	0.15	0.11	lasso	3	0.09	1.6e-05	6.7	6.8	1.2e-11	0.78	0.14	0.85	FALSE
14	GTEx	Breast Mammary Tissue	MPI	0.16	0.00	lasso	8	0.01	1.4e-01	4.4	-5.2	1.6e-07	-0.60	0.05	0.36	FALSE
15	GTEx	Breast Mammary Tissue (Male)	ULK3	0.19	0.19	lasso	2	0.15	2.4e-04	6.3	6.4	1.6e-10	0.67	0.07	0.20	FALSE
16	GTEx	Breast Mammary Tissue (Male)	MPI	0.06	0.01	enet	4	0.03	5.7e-02	4.4	-6.7	2.4e-11	-0.58	0.02	0.15	FALSE
17	GTEx	Breast Mammary Tissue (Female)	ULK3	0.08	0.01	lasso	2	0.01	1.8e-01	7.3	7.2	4.0e-13	0.82	0.04	0.28	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	ULK3	0.19	0.04	lasso	2	0.08	1.2e-03	7.1	7.1	1.6e-12	0.81	0.08	0.76	FALSE
19	GTEx	Cells Transformed fibroblasts	ULK3	0.12	0.04	lasso	5	0.10	8.4e-08	7.0	6.1	8.9e-10	0.75	0.42	0.58	FALSE
20	GTEx	Cells Transformed fibroblasts	MPI	0.21	0.16	enet	15	0.22	1.1e-16	6.4	-6.8	7.9e-12	-0.81	0.29	0.71	FALSE
21	GTEx	Esophagus Mucosa	COX5A	0.11	0.02	enet	23	0.03	6.9e-03	6.3	-5.3	1.4e-07	-0.49	0.08	0.40	FALSE
22	GTEx	Esophagus Mucosa	MPI	0.11	0.11	lasso	7	0.10	2.3e-07	4.5	-5.3	1.4e-07	-0.64	0.71	0.29	FALSE
23	GTEx	Lung	CSK	0.09	0.06	lasso	3	0.05	1.4e-04	7.7	7.7	1.1e-14	0.95	0.02	0.98	FALSE
24	GTEx	Muscle Skeletal	UBL7	0.06	0.02	lasso	6	0.01	3.7e-02	7.4	-7.7	1.1e-14	-0.92	0.02	0.89	TRUE
25	GTEx	Nerve Tibial	MPI	0.10	0.12	enet	12	0.15	1.5e-10	4.4	-6.0	2.1e-09	-0.77	0.19	0.81	FALSE
26	GTEx	Ovary	ULK3	0.19	0.23	lasso	1	0.23	3.0e-06	7.3	7.3	4.0e-13	0.82	0.08	0.53	FALSE
27	GTEx	Pancreas	ULK3	0.12	0.10	lasso	4	0.07	6.9e-04	7.1	7.3	3.6e-13	0.84	0.07	0.90	FALSE
28	GTEx	Skin Sun Exposed Lower leg	MPI	0.04	0.01	lasso	4	0.02	7.4e-03	4.4	-5.6	1.8e-08	-0.72	0.27	0.56	FALSE
29	GTEx	Stomach	ULK3	0.16	0.13	lasso	2	0.11	9.7e-06	7.1	7.2	4.1e-13	0.80	0.19	0.79	FALSE
30	GTEx	Testis	ULK3	0.15	0.03	enet	24	0.06	1.6e-03	7.4	6.3	2.3e-10	0.71	0.08	0.86	FALSE
31	GTEx	Testis	MPI	0.09	0.08	enet	12	0.04	6.0e-03	4.5	-5.8	5.6e-09	-0.67	0.10	0.66	FALSE
32	GTEx	Thyroid	ULK3	0.11	0.09	lasso	4	0.13	5.9e-10	7.3	7.3	4.0e-13	0.74	0.16	0.84	FALSE
33	GTEx	Thyroid	MPI	0.06	0.07	enet	12	0.07	5.1e-06	4.5	-5.4	6.5e-08	-0.66	0.78	0.21	FALSE
34	GTEx	Uterus	ULK3	0.40	0.16	lasso	16	0.12	2.2e-03	7.0	6.6	4.5e-11	0.73	0.04	0.70	FALSE
35	GTEx	Vagina	COX5A	0.38	0.02	lasso	7	0.02	9.3e-02	7.4	-7.3	2.6e-13	-0.84	0.04	0.60	FALSE
36	GTEx	Whole Blood	ULK3	0.14	0.06	lasso	5	0.04	8.3e-05	7.3	6.8	8.1e-12	0.81	0.15	0.82	FALSE
37	GTEx	Whole Blood	MPI	0.04	0.04	lasso	2	0.01	1.7e-02	6.6	-6.4	1.2e-10	-0.64	0.20	0.20	FALSE
38	METSIM	Adipose	MPI	0.08	0.06	blup	273	0.07	3.1e-11	6.4	-5.6	1.8e-08	-0.62	0.99	0.01	FALSE
39	METSIM	Adipose	ULK3	0.14	0.14	lasso	10	0.15	3.2e-22	7.3	7.5	8.4e-14	0.91	0.04	0.96	FALSE
40	YFS	Blood	CSK	0.13	0.15	lasso	11	0.16	6.7e-51	6.8	7.5	9.2e-14	0.90	0.88	0.12	FALSE
41	YFS	Blood	MPI	0.02	0.02	lasso	4	0.03	1.2e-09	6.4	-6.4	1.4e-10	-0.73	0.92	0.08	FALSE
42	YFS	Blood	ULK3	0.09	0.11	lasso	6	0.11	1.1e-33	7.3	7.5	7.7e-14	0.85	0.23	0.77	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	C15orf17	0.02	0.02	lasso	1	0.02	1.9e-05	6.3	-6.3	2.2e-10	-0.72	0.02	0.97	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	MPI	0.04	0.07	enet	13	0.06	5.8e-13	4.5	-5.3	1.2e-07	-0.63	0.87	0.13	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPP25	0.02	0.01	blup	23	0.02	6.8e-05	6.6	5.2	1.9e-07	0.58	0.00	0.98	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	ULK3	0.02	0.02	blup	49	0.02	1.1e-05	7.3	7.5	5.7e-14	0.85	0.02	0.98	FALSE
47	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ULK3	0.21	0.02	enet	8	0.07	1.9e-04	7.4	5.9	3.0e-09	0.70	0.01	0.76	FALSE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	MPI	0.07	0.03	blup	36	0.04	2.1e-03	6.6	-6.4	1.8e-10	-0.72	0.01	0.94	FALSE
49	The Cancer Genome Atlas	Glioblastoma Multiforme	MPI	0.11	0.03	blup	36	0.02	8.4e-02	6.6	-6.5	6.0e-11	-0.73	0.01	0.71	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MPI	0.02	0.01	blup	36	0.01	1.2e-02	6.3	-6.1	1.2e-09	-0.71	0.02	0.66	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CSK	0.02	0.00	blup	57	0.01	1.8e-02	6.9	5.2	1.7e-07	0.66	0.02	0.59	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ULK3	0.03	0.03	lasso	3	0.03	5.3e-04	7.0	7.3	2.3e-13	0.85	0.02	0.97	FALSE
53	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MPI	0.06	0.04	blup	35	0.05	8.5e-04	6.7	-6.6	3.9e-11	-0.75	0.01	0.94	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	MPI	0.07	0.09	lasso	4	0.10	2.4e-11	6.3	-6.1	1.3e-09	-0.72	0.01	0.99	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	SCAMP2	0.18	0.04	enet	5	0.06	6.1e-07	7.3	-5.9	3.0e-09	-0.55	0.03	0.96	FALSE
56	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ULK3	0.10	0.02	blup	49	0.07	2.5e-04	7.5	7.1	1.0e-12	0.85	0.01	0.98	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	C15orf17	0.02	0.03	lasso	1	0.02	1.5e-03	6.4	-6.4	1.9e-10	-0.72	0.01	0.80	FALSE
58	The Cancer Genome Atlas	Lung Adenocarcinoma	ULK3	0.03	0.00	blup	50	0.00	8.1e-02	6.4	6.1	9.7e-10	0.74	0.03	0.40	FALSE
59	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MPI	0.04	0.03	blup	36	0.05	8.8e-07	6.3	-5.8	5.8e-09	-0.68	0.02	0.98	FALSE
60	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ULK3	0.04	0.06	lasso	4	0.04	7.6e-06	7.0	7.2	4.0e-13	0.82	0.02	0.98	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	MPI	0.07	0.07	blup	36	0.10	3.3e-10	4.5	-5.7	9.8e-09	-0.69	0.06	0.94	FALSE
62	The Cancer Genome Atlas	Soft Tissue Sarcoma	ULK3	0.04	0.03	blup	49	0.02	3.3e-02	6.7	5.6	1.9e-08	0.74	0.01	0.66	FALSE
63	The Cancer Genome Atlas	Stomach Adenocarcinoma	COX5A	0.03	0.03	blup	32	0.03	2.9e-03	-3.9	-5.3	1.0e-07	-0.65	0.03	0.47	FALSE
64	The Cancer Genome Atlas	Stomach Adenocarcinoma	MPI	0.04	0.02	blup	36	0.03	1.7e-03	6.4	-6.0	1.6e-09	-0.70	0.03	0.89	FALSE
65	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MPI	0.12	0.11	lasso	7	0.12	5.3e-05	6.3	-6.2	4.4e-10	-0.72	0.02	0.95	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	CSK	0.04	0.04	blup	57	0.04	4.6e-05	7.6	6.0	1.7e-09	0.79	0.01	0.97	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	MPI	0.13	0.18	enet	10	0.16	3.7e-15	4.5	-5.5	4.9e-08	-0.65	0.98	0.02	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	ULK3	0.08	0.11	lasso	5	0.10	4.6e-10	7.0	7.3	3.1e-13	0.85	0.03	0.97	FALSE