[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr1:7,715,776-9,571,422

Best TWAS P=1.71e-11 · Best GWAS P=1.32e-09 conditioned to 0.273

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Breast Mammary Tissue	RERE	0.19	0.08	enet	10	0.14	8.0e-08	-5.9	-6.7	1.7e-11	0.80	0.02	0.98	TRUE
2	GTEx	Adipose Subcutaneous	RP5-1115A15.1	0.14	0.07	enet	20	0.10	2.6e-08	5.3	-6.4	1.4e-10	0.79	0.05	0.94	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	RERE	0.15	0.15	lasso	7	0.15	1.5e-18	-5.9	-6.4	1.7e-10	0.96	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RERE	0.22	0.04	lasso	10	0.08	4.1e-04	5.4	-6.3	3.3e-10	0.85	0.02	0.94	FALSE
7	GTEx	Cells Transformed fibroblasts	RERE	0.12	0.08	lasso	4	0.05	6.0e-05	-6.0	-6.3	3.6e-10	1.00	0.01	0.99	FALSE
3	GTEx	Adipose Visceral Omentum	RERE	0.22	0.17	lasso	5	0.17	5.2e-09	5.4	-6.2	4.1e-10	0.63	0.16	0.83	FALSE
10	GTEx	Nerve Tibial	RERE	0.12	0.09	enet	16	0.11	5.6e-08	-5.9	-6.2	4.4e-10	0.90	0.02	0.98	FALSE
1	GTEx	Adipose Subcutaneous	RERE	0.20	0.23	lasso	2	0.24	1.7e-19	-5.9	-6.2	6.2e-10	0.97	0.02	0.98	FALSE
11	GTEx	Pancreas	RERE	0.11	0.12	lasso	4	0.07	5.9e-04	-6.1	-6.1	9.3e-10	0.98	0.01	0.97	FALSE
15	METSIM	Adipose	RERE	0.08	0.12	lasso	17	0.13	1.8e-19	-5.9	-6.1	1.3e-09	0.89	0.01	0.99	FALSE
18	YFS	Blood	RERE	0.09	0.15	lasso	4	0.16	5.7e-49	5.5	-6.0	2.3e-09	0.74	0.16	0.84	FALSE
5	GTEx	Breast Mammary Tissue	RP5-1115A15.1	0.10	0.07	lasso	2	0.03	7.0e-03	-5.9	-5.9	3.3e-09	0.98	0.01	0.98	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	RERE	0.02	0.03	lasso	2	0.03	4.7e-07	5.5	-5.6	1.9e-08	0.63	0.18	0.81	FALSE
14	GTEx	Whole Blood	RERE	0.19	0.15	lasso	4	0.13	2.7e-12	5.4	-5.6	2.0e-08	0.69	0.20	0.80	FALSE
13	GTEx	Thyroid	RP5-1115A15.1	0.09	0.12	lasso	2	0.09	1.5e-07	5.3	-5.6	2.7e-08	0.68	0.29	0.71	FALSE
12	GTEx	Skin Sun Exposed Lower leg	RP5-1115A15.1	0.07	0.03	enet	13	0.03	1.5e-03	5.4	-5.5	4.9e-08	0.54	0.27	0.57	FALSE
6	GTEx	Breast Mammary Tissue (Female)	RERE	0.14	0.12	lasso	3	0.08	2.4e-03	5.1	-5.4	5.4e-08	0.38	0.08	0.49	FALSE
8	GTEx	Esophagus Mucosa	RERE	0.13	0.16	lasso	3	0.16	7.2e-11	5.4	-5.4	5.8e-08	0.64	0.22	0.78	FALSE
9	GTEx	Lung	RP5-1115A15.1	0.05	0.08	lasso	1	0.07	1.0e-05	5.3	-5.3	1.0e-07	0.65	0.18	0.70	FALSE
16	NTR	Blood	RERE	0.04	0.04	lasso	8	0.03	2.0e-11	4.4	-5.2	1.9e-07	0.66	0.90	0.10	FALSE