Best TWAS P=2.43e-20 · Best GWAS P=1.75e-24 conditioned to 6.52e-11
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SUPT3H | 0.33 | 0.26 | enet | 43 | 0.44 | 2.5e-59 | -2.3 | -5.2 | 1.6e-07 | 0.23 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | SUPT3H | 0.27 | 0.10 | lasso | 7 | 0.06 | 3.4e-04 | 7.1 | -8.5 | 1.5e-17 | 0.42 | 0.96 | 0.02 | FALSE |
| 3 | GTEx | Artery Tibial | SUPT3H | 0.13 | 0.01 | enet | 21 | 0.02 | 1.9e-02 | -6.6 | -7.7 | 1.7e-14 | 0.60 | 0.02 | 0.96 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | SUPT3H | 0.20 | 0.08 | lasso | 6 | 0.10 | 3.0e-04 | 7.4 | -6.1 | 1.3e-09 | 0.09 | 0.42 | 0.03 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | SUPT3H | 0.15 | 0.10 | lasso | 4 | 0.13 | 8.8e-10 | 7.3 | -6.5 | 1.0e-10 | 0.04 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Esophagus Gastroesophageal Junction | SUPT3H | 0.27 | 0.01 | lasso | 3 | 0.00 | 2.7e-01 | -7.1 | -7.7 | 1.4e-14 | 0.40 | 0.10 | 0.25 | FALSE |
| 7 | GTEx | Esophagus Mucosa | SUPT3H | 0.08 | 0.09 | lasso | 3 | 0.08 | 6.4e-06 | 7.1 | -7.7 | 1.1e-14 | 0.29 | 0.84 | 0.05 | FALSE |
| 8 | GTEx | Esophagus Muscularis | SUPT3H | 0.10 | 0.03 | enet | 20 | 0.02 | 1.3e-02 | -7.1 | -6.0 | 1.8e-09 | 0.36 | 0.13 | 0.45 | FALSE |
| 9 | GTEx | Lung | SUPT3H | 0.10 | 0.06 | enet | 21 | 0.03 | 1.3e-03 | 7.2 | -7.7 | 1.1e-14 | 0.24 | 0.84 | 0.02 | FALSE |
| 10 | GTEx | Nerve Tibial | SUPT3H | 0.17 | 0.12 | lasso | 5 | 0.10 | 2.2e-07 | 7.2 | -7.2 | 4.5e-13 | 0.20 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Pancreas | SUPT3H | 0.11 | 0.07 | lasso | 2 | 0.05 | 3.6e-03 | 7.3 | -7.3 | 2.0e-13 | 0.18 | 0.36 | 0.05 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | SUPT3H | 0.07 | 0.03 | lasso | 5 | 0.04 | 4.2e-04 | 7.2 | -8.4 | 6.0e-17 | 0.35 | 0.47 | 0.07 | FALSE |
| 13 | GTEx | Spleen | SUPT3H | 0.32 | 0.06 | enet | 12 | 0.11 | 9.5e-04 | 7.0 | -8.3 | 1.5e-16 | 0.23 | 0.26 | 0.29 | FALSE |
| 14 | GTEx | Thyroid | SUPT3H | 0.29 | 0.07 | lasso | 8 | 0.07 | 7.3e-06 | -7.5 | -7.2 | 6.2e-13 | 0.65 | 0.89 | 0.05 | FALSE |
| 15 | METSIM | Adipose | SUPT3H | 0.11 | 0.04 | bslmm | 657 | 0.06 | 2.7e-09 | 7.3 | -6.7 | 2.3e-11 | 0.26 | 1.00 | 0.00 | FALSE |
| 16 | YFS | Blood | SUPT3H | 0.06 | 0.09 | lasso | 13 | 0.12 | 2.2e-36 | 7.2 | -5.7 | 1.6e-08 | 0.02 | 1.00 | 0.00 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SUPT3H | 0.02 | 0.01 | blup | 191 | 0.01 | 3.0e-03 | 7.1 | -7.2 | 5.3e-13 | 0.18 | 0.86 | 0.00 | FALSE |
| 18 | The Cancer Genome Atlas | Colon Adenocarcinoma | SUPT3H | 0.08 | 0.01 | blup | 191 | 0.05 | 1.0e-03 | 7.3 | -8.2 | 2.2e-16 | 0.37 | 0.28 | 0.08 | FALSE |
| 19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SUPT3H | 0.04 | 0.01 | blup | 191 | 0.02 | 6.5e-03 | -2.2 | -6.2 | 6.2e-10 | 0.15 | 0.67 | 0.01 | FALSE |
| 20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SUPT3H | 0.07 | 0.05 | enet | 12 | 0.08 | 1.1e-09 | -2.2 | -5.8 | 7.9e-09 | 0.03 | 1.00 | 0.00 | FALSE |
| 21 | The Cancer Genome Atlas | Lung Adenocarcinoma | SUPT3H | 0.03 | 0.03 | lasso | 2 | 0.02 | 8.9e-04 | 7.4 | -7.2 | 5.8e-13 | 0.19 | 0.30 | 0.07 | FALSE |
| 22 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SUPT3H | 0.12 | 0.08 | blup | 191 | 0.09 | 2.8e-04 | 7.2 | -8.4 | 3.7e-17 | 0.30 | 0.67 | 0.03 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | SUPT3H | 0.06 | 0.04 | lasso | 4 | 0.05 | 2.1e-05 | 7.4 | -9.2 | 2.4e-20 | 0.49 | 0.66 | 0.13 | TRUE |