1022 significantly associated models · 277 unique genes
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# | chr | p0 | p1 | # assoc genes | # joint genes | best TWAS P | best SNP P | cond SNP P | % var exp | joint genes |
---|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 752566 | 1567206 | 1 | 1 | 4.4e-08 | 4.9e-07 | 1.0e+00 | 100 | KLHL17 |
2 | 1 | 7686056 | 9571422 | 3 | 1 | 2.0e-14 | 6.8e-12 | 3.2e-01 | 98 | RERE |
3 | 1 | 15123100 | 16844848 | 6 | 2 | 6.0e-11 | 4.0e-10 | 6.9e-01 | 100 | C1orf134 CASP9 |
4 | 1 | 18972776 | 20503710 | 1 | 1 | 1.6e-07 | 2.3e-08 | 3.0e-02 | 85 | CAPZB |
5 | 1 | 22197336 | 22718991 | 1 | 1 | 1.3e-16 | 5.0e-22 | 2.0e-24 | -12 | WNT4 |
6 | 1 | 37764586 | 39167106 | 1 | 1 | 1.9e-08 | 3.7e-07 | 7.1e-01 | 100 | FHL3 |
7 | 1 | 112312154 | 114196883 | 4 | 1 | 6.2e-16 | 7.0e-15 | 1.0e+00 | 100 | WNT2B |
8 | 1 | 118878656 | 120380990 | 1 | 1 | 1.0e-07 | 1.4e-09 | 7.6e-06 | 45 | WARS2 |
9 | 1 | 219166366 | 220808921 | 1 | 1 | 4.6e-09 | 9.7e-10 | 6.8e-02 | 91 | SLC30A10 |
10 | 1 | 239954252 | 241470634 | 1 | 1 | 9.9e-41 | 1.2e-53 | 1.3e-16 | 71 | GREM2 |
11 | 2 | 39636469 | 41534961 | 1 | 1 | 3.5e-09 | 1.7e-12 | 7.1e-08 | 42 | SLC8A1 |
12 | 2 | 41579722 | 42984340 | 1 | 1 | 2.9e-12 | 1.9e-25 | 3.3e-15 | 43 | PKDCC |
13 | 2 | 53583159 | 55895321 | 9 | 9 | 2.1e-46 | 5.6e-66 | NaN | NaN | AC092839.1 AC093110.3 ACYP2 C2orf73 EML6 RPL23AP32 SPTBN1 |
14 | 2 | 64168232 | 65573478 | 1 | 1 | 1.5e-07 | 4.7e-08 | 3.5e-02 | 85 | SERTAD2 |
15 | 2 | 202200575 | 203592180 | 1 | 1 | 5.9e-10 | 6.5e-30 | 6.4e-27 | 11 | FZD7 |
16 | 3 | 48012797 | 50800146 | 23 | 1 | 2.9e-12 | 7.5e-12 | 5.1e-02 | 92 | AMT |
17 | 3 | 155695485 | 157456920 | 4 | 2 | 1.7e-15 | 1.4e-13 | 3.5e-01 | 98 | LEKR1 TIPARP |
18 | 4 | 69713 | 2058475 | 14 | 12 | 2.8e-36 | 6.0e-33 | NaN | NaN | CRIPAK FGFRL1 IDUA MYL5 RP11-20I20.4 TMEM175 |
19 | 4 | 57587795 | 58088682 | 1 | 1 | 2.9e-09 | 4.8e-10 | 1.0e+00 | 100 | C4orf14 |
20 | 4 | 85698680 | 89692911 | 6 | 4 | 1.5e-12 | 5.7e-12 | 1.0e+00 | 100 | HSD17B13 IBSP RP13-514E23.2 SPP1 |
21 | 4 | 144882744 | 147278056 | 3 | 2 | 1.4e-12 | 2.5e-13 | 4.1e-03 | 85 | HHIP-AS1 MMAA |
22 | 5 | 39132847 | 39670061 | 1 | 1 | 7.1e-09 | 3.5e-09 | 1.6e-04 | 59 | DAB2 |
23 | 5 | 42179899 | 42967215 | 1 | 1 | 1.8e-08 | 2.0e-08 | 4.0e-01 | 98 | GHR |
24 | 5 | 53906103 | 55410585 | 1 | 1 | 2.5e-07 | 1.2e-06 | 9.4e-01 | 100 | SKIV2L2 |
25 | 5 | 80008704 | 80761967 | 1 | 1 | 1.3e-12 | 7.8e-13 | 1.0e+00 | 100 | RASGRF2 |
26 | 6 | 44079216 | 46043561 | 1 | 1 | 2.4e-20 | 1.7e-24 | 6.5e-11 | 59 | SUPT3H |
27 | 6 | 73710903 | 75236060 | 1 | 1 | 3.1e-10 | 4.8e-13 | 3.6e-04 | 76 | CD109 |
28 | 6 | 126892049 | 128307725 | 2 | 1 | 6.9e-74 | 4.5e-88 | 9.2e-16 | 84 | RSPO3 |
29 | 6 | 132394840 | 134546685 | 5 | 3 | 2.6e-13 | 8.8e-42 | 8.6e-23 | 47 | C6orf192 EYA4 |
30 | 6 | 151118271 | 153120904 | 4 | 9 | 5.3e-83 | 1.8e-69 | 1.4e-03 | 97 | C6orf97 CCDC170 ESR1 |
31 | 7 | 26871554 | 28568019 | 3 | 1 | 2.3e-10 | 1.9e-15 | 1.6e-11 | 28 | AC004549.6 |
32 | 7 | 37260712 | 38687833 | 1 | 4 | 4.9e-25 | 5.8e-41 | 5.5e-03 | 96 | EPDR1 |
33 | 7 | 91380845 | 93160671 | 2 | 1 | 6.3e-10 | 2.6e-09 | 2.8e-01 | 97 | CDK6 |
34 | 7 | 119892061 | 121729795 | 5 | 7 | 1.8e-235 | 0.0e+00 | NaN | NaN | C7orf58 CPED1 FAM3C |
35 | 7 | 148285882 | 149691341 | 1 | 1 | 1.6e-07 | 1.0e-07 | 1.0e+00 | 100 | RP4-800G7.2 |
36 | 7 | 150034951 | 151443931 | 1 | 1 | 9.1e-08 | 1.7e-07 | 2.5e-02 | 82 | ABCB8 |
37 | 8 | 8092025 | 13120332 | 39 | 10 | 1.6e-22 | 1.9e-26 | NaN | NaN | AF131215.9 ERI1 FAM167A FAM66D FAM85A FLJ10661 SGK223 |
38 | 8 | 70890495 | 72399360 | 1 | 1 | 1.0e-07 | 8.3e-10 | 1.9e-08 | 16 | XKR9 |
39 | 9 | 96102832 | 97759920 | 3 | 2 | 1.0e-08 | 3.4e-09 | 1.3e-02 | 82 | BARX1 ZNF169 |
40 | 10 | 30887952 | 31565621 | 1 | 1 | 1.8e-07 | 2.3e-25 | 1.4e-19 | 24 | ZNF438 |
41 | 10 | 122801759 | 124407934 | 2 | 2 | 3.2e-10 | 8.0e-10 | 7.4e-03 | 81 | RP11-500G22.2 |
42 | 11 | 16072004 | 17469466 | 1 | 1 | 1.4e-07 | 4.5e-10 | 4.0e-05 | 57 | C11orf58 |
43 | 11 | 26818083 | 28220506 | 1 | 1 | 3.2e-13 | 3.2e-27 | 5.0e-17 | 40 | LIN7C |
44 | 11 | 34460769 | 35949179 | 1 | 1 | 1.6e-11 | 4.9e-12 | 1.0e+00 | 100 | CD44 |
45 | 11 | 46010847 | 48285906 | 13 | 1 | 1.6e-16 | 6.9e-17 | 1.0e+00 | 100 | ARFGAP2 |
46 | 11 | 59239839 | 60645214 | 4 | 1 | 3.3e-10 | 1.3e-10 | 1.6e-03 | 76 | MS4A4A |
47 | 11 | 60869481 | 62346131 | 4 | 1 | 2.4e-10 | 3.4e-08 | 4.3e-01 | 98 | FADS2 |
48 | 11 | 64669105 | 66714782 | 4 | 2 | 2.0e-12 | 5.2e-08 | 9.1e-01 | 100 | RP11-867G23.1 SIPA1 |
49 | 11 | 67533195 | 69623641 | 8 | 3 | 1.5e-16 | 9.2e-21 | 1.6e-03 | 89 | GAL SAPS3 TPCN2 |
50 | 11 | 111354161 | 112921923 | 2 | 1 | 1.2e-30 | 3.2e-48 | 2.6e-19 | 62 | RP11-356J5.12 |
51 | 11 | 114340771 | 116072203 | 1 | 1 | 9.4e-12 | 9.4e-16 | 1.9e-05 | 72 | CADM1 |
52 | 12 | 191619 | 1368535 | 1 | 1 | 2.0e-07 | 1.1e-06 | 7.1e-01 | 99 | B4GALNT3 |
53 | 12 | 25417418 | 26928426 | 1 | 1 | 5.9e-09 | 2.2e-07 | 6.3e-02 | 87 | RASSF8 |
54 | 12 | 49827409 | 51256065 | 1 | 1 | 2.2e-07 | 3.9e-05 | 2.8e-01 | 93 | CERS5 |
55 | 12 | 53414010 | 53932834 | 1 | 1 | 3.1e-07 | 8.2e-08 | 1.0e+00 | 100 | ESPL1 |
56 | 12 | 123558705 | 125155900 | 3 | 1 | 3.7e-09 | 1.0e-06 | 1.7e-01 | 92 | DNAH10 |
57 | 13 | 49557805 | 50962458 | 1 | 1 | 5.3e-09 | 1.4e-06 | 4.3e-03 | 65 | EBPL |
58 | 13 | 98746497 | 100437143 | 2 | 3 | 1.4e-17 | 3.3e-19 | 4.9e-02 | 95 | DOCK9 DOCK9-AS2 |
59 | 14 | 34754717 | 36242995 | 2 | 1 | 1.4e-10 | 1.4e-10 | 1.0e+00 | 100 | SRP54 |
60 | 14 | 53731553 | 55118795 | 1 | 1 | 2.4e-34 | 2.3e-34 | 8.7e-07 | 84 | BMP4 |
61 | 14 | 60168943 | 61664530 | 1 | 1 | 3.7e-08 | 6.4e-08 | 3.3e-01 | 97 | C14orf39 |
62 | 14 | 103161201 | 104892153 | 8 | 1 | 8.0e-17 | 4.3e-17 | 1.0e+00 | 100 | MARK3 |
63 | 15 | 51255019 | 51946100 | 2 | 2 | 2.7e-13 | 2.2e-14 | 2.2e-04 | 77 | CYP19A1 GLDN |
64 | 15 | 90208219 | 91886448 | 3 | 1 | 1.4e-08 | 5.8e-09 | 1.2e-01 | 93 | IQGAP1 |
65 | 16 | 86671 | 1100776 | 2 | 2 | 6.8e-08 | 7.8e-09 | 5.7e-02 | 89 | RGS11 TMEM8A |
66 | 16 | 66545982 | 68125316 | 5 | 1 | 1.6e-10 | 6.3e-14 | 4.4e-05 | 70 | TPPP3 |
67 | 17 | 1717695 | 2453908 | 1 | 1 | 1.6e-16 | 2.3e-20 | 5.9e-07 | 71 | SMG6 |
68 | 17 | 27658233 | 28161482 | 1 | 1 | 1.5e-07 | 5.2e-07 | 5.2e-01 | 98 | GIT1 |
69 | 17 | 41393295 | 42998534 | 7 | 1 | 6.9e-14 | 3.3e-17 | 1.5e-12 | 30 | HDAC5 |
70 | 18 | 12966058 | 14385836 | 2 | 2 | 6.9e-08 | 6.3e-24 | 2.6e-14 | 43 | FAM210A RNMT |
71 | 19 | 32482073 | 34392158 | 9 | 12 | 4.7e-47 | 4.8e-46 | NaN | NaN | CEP89 CTD-2538C1.2 GPATCH1 RHPN2 WDR88 |
72 | 19 | 41479309 | 42009673 | 1 | 1 | 2.8e-07 | 7.1e-05 | 3.3e-03 | 45 | AXL |
73 | 20 | 10374093 | 10903755 | 1 | 1 | 3.1e-09 | 6.5e-13 | 7.0e-11 | 18 | JAG1 |
74 | 20 | 32819871 | 34556216 | 5 | 1 | 7.0e-10 | 1.1e-09 | 1.0e+00 | 100 | MYH7B |
75 | 20 | 39567774 | 40193393 | 1 | 1 | 2.3e-08 | 8.4e-11 | 9.1e-04 | 74 | ZHX3 |
76 | 22 | 19003938 | 20330744 | 1 | 1 | 8.0e-09 | 2.2e-40 | 2.9e-33 | 18 | SEPT5 |
77 | 22 | 27675538 | 30261219 | 5 | 9 | 6.8e-23 | 5.8e-23 | 1.0e+00 | 100 | C22orf31 KREMEN1 TTC28 XBP1 |
78 | 22 | 38388203 | 39770597 | 1 | 1 | 2.1e-07 | 9.7e-07 | 6.2e-01 | 99 | TOMM22 |
79 | 22 | 40789606 | 42301748 | 2 | 1 | 9.7e-08 | 4.1e-08 | 1.0e+00 | 100 | L3MBTL2 |
80 | 22 | 49550794 | 50999182 | 2 | 1 | 7.5e-09 | 4.1e-09 | 9.3e-02 | 92 | ALG12 |
Trait | chisq ratio | # genes+ | # genes++ | % genes++ | corr | corr P | genes |
---|
study | tissue | # hits | % hits/tests | avg chisq |
---|
study | tissue | # hits | % hits/tests | avg chisq |
---|---|---|---|---|
GTEx | Artery Tibial | 32 | 0.85 | 2.7 |
GTEx | Pancreas | 19 | 1.16 | 2.7 |
GTEx | Brain Hippocampus | 2 | 0.38 | 2.6 |
GTEx | Uterus | 4 | 0.71 | 2.6 |
GTEx | Adipose Visceral Omentum | 18 | 0.88 | 2.5 |
GTEx | Brain Cortex | 8 | 0.77 | 2.5 |
GTEx | Breast Mammary Tissue | 12 | 0.61 | 2.5 |
GTEx | Ovary | 4 | 0.44 | 2.5 |
GTEx | Prostate | 7 | 0.84 | 2.5 |
GTEx | Skin Not Sun Exposed Suprapubic | 19 | 0.77 | 2.5 |
GTEx | Skin Sun Exposed Lower leg | 24 | 0.66 | 2.5 |
GTEx | Small Intestine Terminal Ileum | 2 | 0.43 | 2.5 |
ROSMAP | Brain Pre-frontal Cortex | 42 | 0.96 | 2.5 |
The Cancer Genome Atlas | Glioblastoma Multiforme | 7 | 0.68 | 2.5 |
The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | 10 | 0.63 | 2.5 |
The Cancer Genome Atlas | Pancreatic Adenocarcinoma | 12 | 0.72 | 2.5 |
The Cancer Genome Atlas | Skin Cutaneous Melanoma | 4 | 0.75 | 2.5 |
The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | 4 | 0.79 | 2.5 |
GTEx | Adipose Subcutaneous | 22 | 0.63 | 2.4 |
GTEx | Artery Aorta | 26 | 0.87 | 2.4 |
GTEx | Brain Caudate basal ganglia | 6 | 0.65 | 2.4 |
GTEx | Brain Cerebellar Hemisphere | 10 | 0.67 | 2.4 |
GTEx | Brain Frontal Cortex BA9 | 5 | 0.54 | 2.4 |
GTEx | Brain Putamen basal ganglia | 5 | 0.80 | 2.4 |
GTEx | Cells EBV-transformed lymphocytes | 8 | 0.56 | 2.4 |
GTEx | Esophagus Gastroesophageal Junction | 12 | 0.83 | 2.4 |
GTEx | Heart Left Ventricle | 11 | 0.72 | 2.4 |
GTEx | Lung | 20 | 0.70 | 2.4 |
GTEx | Nerve Tibial | 31 | 0.72 | 2.4 |
GTEx | Spleen | 9 | 0.64 | 2.4 |
GTEx | Thyroid | 22 | 0.55 | 2.4 |
GTEx | Vagina | 4 | 0.63 | 2.4 |
NTR | Blood | 21 | 0.87 | 2.4 |
The Cancer Genome Atlas | Bladder Urothelial Carcinoma | 11 | 0.66 | 2.4 |
The Cancer Genome Atlas | Breast Invasive Carcinoma | 38 | 0.86 | 2.4 |
The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | 15 | 1.13 | 2.4 |
GTEx | Artery Coronary | 5 | 0.42 | 2.3 |
GTEx | Brain Hypothalamus | 2 | 0.34 | 2.3 |
GTEx | Breast Mammary Tissue (Male) | 11 | 0.92 | 2.3 |
GTEx | Breast Mammary Tissue (Female) | 9 | 0.55 | 2.3 |
GTEx | Cells Transformed fibroblasts | 21 | 0.50 | 2.3 |
GTEx | Colon Sigmoid | 4 | 0.27 | 2.3 |
GTEx | Esophagus Mucosa | 21 | 0.63 | 2.3 |
GTEx | Esophagus Muscularis | 22 | 0.68 | 2.3 |
GTEx | Heart Atrial Appendage | 10 | 0.63 | 2.3 |
GTEx | Pituitary | 4 | 0.36 | 2.3 |
GTEx | Stomach | 9 | 0.62 | 2.3 |
GTEx | Testis | 23 | 0.73 | 2.3 |
The Cancer Genome Atlas | Colon Adenocarcinoma | 17 | 0.82 | 2.3 |
The Cancer Genome Atlas | Soft Tissue Sarcoma | 7 | 0.66 | 2.3 |
The Cancer Genome Atlas | Stomach Adenocarcinoma | 13 | 0.77 | 2.3 |
GTEx | Adrenal Gland | 6 | 0.41 | 2.2 |
GTEx | Brain Cerebellum | 10 | 0.50 | 2.2 |
GTEx | Brain Nucleus accumbens basal ganglia | 4 | 0.46 | 2.2 |
GTEx | Colon Transverse | 17 | 0.82 | 2.2 |
GTEx | Whole Blood | 13 | 0.65 | 2.2 |
METSIM | Adipose | 29 | 0.63 | 2.2 |
CommonMind | Brain Pre-frontal Cortex | 33 | 0.61 | 2.2 |
The Cancer Genome Atlas | Esophageal Carcinoma | 5 | 0.73 | 2.2 |
The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | 17 | 0.62 | 2.2 |
The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | 31 | 0.76 | 2.2 |
The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | 15 | 0.73 | 2.2 |
The Cancer Genome Atlas | Brain Lower Grade Glioma | 26 | 0.60 | 2.2 |
The Cancer Genome Atlas | Lung Adenocarcinoma | 14 | 0.48 | 2.2 |
The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | 12 | 0.48 | 2.2 |
The Cancer Genome Atlas | Prostate Adenocarcinoma | 26 | 0.56 | 2.2 |
GTEx | Liver | 2 | 0.28 | 2.1 |
GTEx | Muscle Skeletal | 12 | 0.42 | 2.1 |
The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | 6 | 0.55 | 2.1 |
The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | 3 | 0.27 | 2.1 |
The Cancer Genome Atlas | Rectum Adenocarcinoma | 4 | 0.58 | 2.1 |
The Cancer Genome Atlas | Testicular Germ Cell Tumors | 8 | 0.63 | 2.1 |
The Cancer Genome Atlas | Thyroid Carcinoma | 26 | 0.50 | 2.1 |
YFS | Blood | 19 | 0.41 | 2.0 |