Best TWAS P=2.51e-08 · Best GWAS P=3.22e-08 conditioned to 0.332
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RPS6KL1 | 0.04 | 0.02 | lasso | 5 | 0.02 | 4.8e-04 | 4.5 | -5.2 | 1.7e-07 | -0.54 | 0.15 | 0.57 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | YLPM1 | 0.10 | 0.03 | lasso | 6 | 0.02 | 7.9e-03 | -4.9 | 5.6 | 2.5e-08 | 0.64 | 0.05 | 0.65 | TRUE |
| 3 | GTEx | Adrenal Gland | RPS6KL1 | 0.21 | 0.13 | enet | 25 | 0.15 | 4.4e-06 | 4.2 | 5.1 | 2.9e-07 | 0.56 | 0.34 | 0.56 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | NPC2 | 0.11 | 0.11 | enet | 11 | 0.10 | 2.7e-08 | 3.8 | 5.3 | 9.7e-08 | 0.23 | 0.92 | 0.05 | TRUE |
| 5 | GTEx | Spleen | NPC2 | 0.30 | 0.08 | enet | 10 | 0.06 | 1.5e-02 | 5.5 | 5.2 | 2.5e-07 | 0.94 | 0.02 | 0.90 | FALSE |
| 6 | GTEx | Testis | AREL1 | 0.20 | 0.14 | enet | 34 | 0.13 | 2.1e-06 | 4.8 | 5.5 | 5.0e-08 | 0.70 | 0.11 | 0.89 | FALSE |