Best TWAS P=4.63e-09 · Best GWAS P=1.99e-10 conditioned to 0.0131
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cerebellar Hemisphere | LRPPRC | 0.34 | 0.15 | enet | 13 | 0.10 | 1.5e-03 | -6.4 | 5.5 | 5.0e-08 | -0.80 | 0.02 | 0.90 | FALSE |
2 | GTEx | Brain Cortex | LRPPRC | 0.17 | 0.10 | lasso | 3 | 0.11 | 4.9e-04 | 5.1 | 5.9 | 4.6e-09 | -0.91 | 0.03 | 0.84 | TRUE |
3 | GTEx | Nerve Tibial | LRPPRC | 0.25 | 0.07 | lasso | 6 | 0.04 | 6.4e-04 | 5.1 | 5.6 | 2.2e-08 | -0.84 | 0.06 | 0.94 | FALSE |
4 | GTEx | Testis | LRPPRC | 0.30 | 0.20 | enet | 16 | 0.19 | 5.3e-09 | 5.3 | 5.2 | 2.3e-07 | -0.79 | 0.58 | 0.42 | FALSE |
5 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LRPPRC | 0.06 | 0.04 | lasso | 2 | 0.05 | 2.8e-03 | 5.3 | 5.3 | 1.3e-07 | -0.80 | 0.06 | 0.33 | FALSE |
6 | The Cancer Genome Atlas | Lung Adenocarcinoma | LRPPRC | 0.09 | 0.11 | lasso | 3 | 0.10 | 5.6e-12 | 5.2 | 5.2 | 2.2e-07 | -0.79 | 0.82 | 0.18 | FALSE |
7 | The Cancer Genome Atlas | Rectum Adenocarcinoma | LRPPRC | 0.27 | 0.12 | blup | 109 | 0.13 | 7.3e-04 | 4.3 | 5.5 | 3.0e-08 | -0.80 | 0.09 | 0.59 | FALSE |
8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | LRPPRC | 0.17 | 0.14 | lasso | 6 | 0.13 | 2.3e-05 | 5.2 | 5.1 | 2.8e-07 | -0.76 | 0.44 | 0.51 | FALSE |