Best TWAS P=4.48e-15 · Best GWAS P=2.29e-14 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADCY3 | 0.16 | 0.12 | lasso | 10 | 0.14 | 3.2e-17 | -6.61 | 6.7 | 1.6e-11 | -0.40 | 0.23 | 0.77 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | CENPO | 0.07 | 0.03 | bslmm | 322 | 0.03 | 7.0e-05 | -4.54 | 7.1 | 1.0e-12 | -0.71 | 0.05 | 0.92 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | ADCY3 | 0.07 | 0.04 | lasso | 6 | 0.01 | 3.2e-02 | -7.17 | -6.1 | 1.0e-09 | 0.34 | 0.05 | 0.94 | FALSE |
| 4 | GTEx | Adrenal Gland | PTRHD1 | 0.32 | 0.28 | lasso | 3 | 0.26 | 8.3e-10 | 5.02 | -5.2 | 2.5e-07 | 0.33 | 0.98 | 0.01 | FALSE |
| 5 | GTEx | Artery Tibial | ADCY3 | 0.21 | 0.14 | lasso | 6 | 0.15 | 4.3e-12 | -6.55 | -7.3 | 2.9e-13 | 0.51 | 0.18 | 0.82 | FALSE |
| 6 | GTEx | Artery Tibial | RP11-443B20.1 | 0.17 | 0.08 | enet | 40 | 0.09 | 8.2e-08 | -6.55 | -5.9 | 3.3e-09 | 0.47 | 0.08 | 0.91 | FALSE |
| 7 | GTEx | Cells EBV-transformed lymphocytes | ADCY3 | 0.25 | 0.23 | enet | 10 | 0.12 | 9.2e-05 | -7.17 | 7.0 | 2.4e-12 | -0.38 | 0.11 | 0.86 | FALSE |
| 8 | GTEx | Cells EBV-transformed lymphocytes | RP11-443B20.1 | 0.13 | 0.13 | enet | 9 | 0.05 | 9.2e-03 | -7.17 | 7.2 | 5.4e-13 | -0.38 | 0.07 | 0.80 | TRUE |
| 9 | GTEx | Esophagus Mucosa | TP53I3 | 0.16 | 0.03 | enet | 23 | 0.06 | 8.2e-05 | 0.75 | -5.2 | 2.6e-07 | 0.18 | 0.02 | 0.23 | TRUE |
| 10 | GTEx | Lung | NCOA1 | 0.12 | 0.04 | lasso | 7 | 0.06 | 1.9e-05 | -3.02 | -7.0 | 2.9e-12 | 0.64 | 0.04 | 0.93 | TRUE |
| 11 | GTEx | Nerve Tibial | ADCY3 | 0.09 | 0.05 | enet | 6 | 0.03 | 2.2e-03 | -6.55 | 7.6 | 2.8e-14 | -0.42 | 0.05 | 0.94 | FALSE |
| 12 | GTEx | Nerve Tibial | RP11-443B20.1 | 0.07 | 0.03 | enet | 6 | 0.02 | 1.1e-02 | -6.55 | 7.5 | 5.9e-14 | -0.44 | 0.06 | 0.91 | TRUE |
| 13 | GTEx | Whole Blood | DNAJC27 | 0.08 | 0.10 | lasso | 1 | 0.10 | 2.2e-09 | -7.15 | -7.2 | 8.9e-13 | 0.41 | 0.08 | 0.92 | TRUE |
| 14 | GTEx | Whole Blood | ADCY3 | 0.23 | 0.24 | enet | 24 | 0.27 | 5.5e-25 | -7.43 | -7.8 | 5.2e-15 | 0.45 | 0.04 | 0.96 | FALSE |
| 15 | GTEx | Whole Blood | RP11-443B20.1 | 0.21 | 0.17 | enet | 32 | 0.20 | 1.8e-18 | -7.15 | -7.6 | 3.0e-14 | 0.42 | 0.05 | 0.95 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | ADCY3 | 0.17 | 0.26 | enet | 32 | 0.26 | 6.8e-33 | -7.43 | 7.8 | 4.5e-15 | -0.43 | 0.03 | 0.97 | TRUE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADCY3 | 0.05 | 0.03 | blup | 81 | 0.03 | 5.0e-07 | -2.84 | 6.1 | 1.3e-09 | -0.70 | 0.37 | 0.60 | TRUE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADCY3 | 0.03 | 0.02 | blup | 81 | 0.02 | 7.1e-04 | -5.02 | 6.4 | 1.5e-10 | -0.33 | 0.08 | 0.84 | FALSE |