Best TWAS P=1.24e-13 · Best GWAS P=2.83e-11 conditioned to 0.0201
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AQP11 | 0.14 | 0.11 | lasso | 7 | 0.13 | 1.0e-15 | -4.0 | -6.2 | 7.5e-10 | -0.59 | 0.98 | 0.02 | FALSE |
| 2 | GTEx | Artery Aorta | CLNS1A | 0.11 | 0.01 | enet | 25 | 0.03 | 7.4e-03 | 6.3 | -5.2 | 2.6e-07 | -0.49 | 0.05 | 0.88 | FALSE |
| 3 | GTEx | Artery Tibial | AP000580.1 | 0.12 | 0.08 | lasso | 7 | 0.09 | 1.1e-07 | 5.2 | -5.9 | 3.4e-09 | -0.78 | 0.05 | 0.95 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Male) | AP000580.1 | 0.31 | 0.04 | lasso | 4 | 0.09 | 3.6e-03 | -5.7 | -6.8 | 1.0e-11 | -0.49 | 0.05 | 0.36 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | AP000580.1 | 0.12 | 0.02 | enet | 18 | 0.08 | 1.1e-06 | 6.3 | -6.0 | 2.5e-09 | -0.56 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | AP000580.1 | 0.09 | 0.09 | lasso | 4 | 0.07 | 1.1e-06 | 6.3 | -6.3 | 3.8e-10 | -0.74 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Thyroid | AP000580.1 | 0.08 | 0.04 | lasso | 3 | 0.05 | 1.2e-04 | 6.3 | -6.4 | 1.7e-10 | -0.79 | 0.03 | 0.92 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | AQP11 | 0.07 | 0.02 | blup | 320 | 0.05 | 1.5e-06 | 6.3 | -7.4 | 1.2e-13 | -0.66 | 0.01 | 0.99 | TRUE |
| 9 | YFS | Blood | AQP11 | 0.01 | 0.02 | lasso | 2 | 0.02 | 2.0e-06 | -5.8 | -5.8 | 6.2e-09 | -0.45 | 0.29 | 0.71 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | AQP11 | 0.04 | 0.01 | blup | 39 | 0.02 | 9.1e-04 | -2.6 | -5.4 | 8.6e-08 | -0.44 | 0.12 | 0.30 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AQP11 | 0.07 | 0.01 | blup | 39 | 0.03 | 9.7e-05 | -5.8 | -7.1 | 1.8e-12 | -0.69 | 0.03 | 0.84 | FALSE |
| 12 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | AQP11 | 0.04 | 0.04 | lasso | 1 | 0.02 | 9.5e-03 | -5.8 | -5.8 | 6.4e-09 | -0.45 | 0.04 | 0.20 | FALSE |
| 13 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C11orf67 | 0.08 | 0.09 | lasso | 9 | 0.07 | 1.0e-03 | -6.2 | 6.1 | 1.4e-09 | 0.43 | 0.02 | 0.75 | FALSE |
| 14 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | AQP11 | 0.11 | 0.04 | lasso | 3 | 0.06 | 3.3e-03 | -5.8 | -5.6 | 2.0e-08 | -0.42 | 0.06 | 0.28 | FALSE |