Best TWAS P=1.3e-20 · Best GWAS P=4.73e-22 conditioned to 0.704
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | AP001372.2 | 0.10 | 0.02 | enet | 13 | 0.05 | 0.0002 | -1.8 | 6.9 | 6.5e-12 | 0.48 | 0.13 | 0.35 | FALSE |
| 2 | GTEx | Testis | POLD3 | 0.18 | -0.01 | enet | 48 | 0.00 | 0.2900 | 2.4 | -7.1 | 1.5e-12 | -0.58 | 0.02 | 0.72 | TRUE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | C2CD3 | 0.04 | 0.01 | blup | 446 | 0.02 | 0.0021 | 2.2 | 5.7 | 9.0e-09 | 0.33 | 0.21 | 0.26 | TRUE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | POLD3 | 0.02 | 0.01 | lasso | 3 | 0.01 | 0.0018 | 8.3 | -9.3 | 1.3e-20 | -0.65 | 0.08 | 0.18 | TRUE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | POLD3 | 0.03 | 0.00 | blup | 77 | 0.01 | 0.0133 | 8.5 | -6.4 | 2.0e-10 | -0.32 | 0.04 | 0.07 | FALSE |