Best TWAS P=1.77e-13 · Best GWAS P=1.02e-11 conditioned to 0.671
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AMZ1 | 0.19 | 0.12 | enet | 22 | 0.13 | 5.7e-16 | 5.3 | 6.3 | 3.7e-10 | -0.43 | 0.93 | 0.07 | FALSE |
| 2 | GTEx | Artery Tibial | GNA12 | 0.24 | 0.13 | enet | 20 | 0.22 | 3.5e-17 | -6.4 | -5.2 | 2.5e-07 | 0.84 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | GNA12 | 0.46 | 0.51 | lasso | 5 | 0.50 | 7.9e-19 | -6.8 | -6.7 | 2.3e-11 | 0.99 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Esophagus Muscularis | GNA12 | 0.32 | 0.31 | lasso | 3 | 0.34 | 2.1e-21 | -6.4 | -6.1 | 9.8e-10 | 0.94 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Whole Blood | GNA12 | 0.09 | 0.01 | enet | 4 | 0.00 | 3.3e-01 | -6.4 | -6.6 | 3.3e-11 | 0.94 | 0.02 | 0.92 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | AMZ1 | 0.09 | 0.05 | lasso | 6 | 0.04 | 2.4e-06 | -6.4 | 7.4 | 1.8e-13 | -0.90 | 0.05 | 0.95 | TRUE |
| 7 | YFS | Blood | GNA12 | 0.23 | 0.15 | bslmm | 570 | 0.25 | 4.5e-82 | 5.3 | -5.7 | 1.4e-08 | 0.52 | 0.96 | 0.04 | FALSE |
| 8 | The Cancer Genome Atlas | Esophageal Carcinoma | AMZ1 | 0.18 | 0.05 | blup | 69 | 0.05 | 1.4e-02 | 4.5 | -6.4 | 1.7e-10 | 0.71 | 0.01 | 0.70 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | GNA12 | 0.03 | 0.01 | enet | 7 | 0.02 | 1.5e-03 | 2.2 | -5.3 | 1.4e-07 | 0.78 | 0.05 | 0.77 | FALSE |