TWAS
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Models
Genes
Traits
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Traits
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Hip circumference
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chr12:132,613,274-133,778,796
Best TWAS P=1.63e-08 · Best GWAS P=4.18e-09 conditioned to 1
132.6M
132.8M
133M
133.2M
133.4M
133.6M
133.8M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Adrenal Gland
ZNF605
0.23
0.07
lasso
9
0.06
4.5e-03
5.8
5.6
1.6e-08
0.95
0.01
0.96
TRUE
4
The Cancer Genome Atlas
Breast Invasive Carcinoma
ANKLE2
0.04
0.02
lasso
2
0.02
5.8e-06
5.7
5.6
2.6e-08
0.96
0.00
1.00
FALSE
2
GTEx
Breast Mammary Tissue (Female)
ANKLE2
0.11
0.01
enet
17
0.06
7.4e-03
4.7
5.4
8.3e-08
0.67
0.02
0.51
FALSE
3
GTEx
Muscle Skeletal
ANKLE2
0.06
0.01
enet
17
0.03
8.8e-04
5.8
5.2
2.0e-07
0.74
0.00
0.96
FALSE